AlzGene - Gene overview of all published AD-association studies for UBQLN1
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 Gene: UBQLN1   Entrez Gene    View on PDGene
 Protein: ubiquilin 1   ProteinLink
 Chromosome: 9   (View: 1  2  3  4  5  6  7  8  9  10  11  12  13  14  15  16  17  18  19  20  21  22  X  Y  MT)
 Status: Updated 12 September 2010
Meta-Analysis
1. Case-Control Studies (by ethnic group)
      AD Cases Normal Controls    
Study Population Source # Polys # Subjects
(% women)
DX Onset Age
(range)
Age
(range)
# Subjects
(% women)
Age
(range)
Result Comment
 Caucasian
Arias-Vasquez, 2007
Netherlands PO  1  (detail)  549
(-)
C--5728
(-)
-Negative
Bensemain, 2006
France CL  1  (detail)  613
(61%)
C69.5 + 7.4
(-)
72.4 + 7.2
(-)
653
(64%)
72.5 + 7.9
(-)
Negative
Brouwers, 2005
Belgium CL  1  (detail)  182
(55%)
C63.7 + 6
(-)
-183
(56%)
59.2 + 16.7
(-)
Negative
Brouwers, 2005
Netherlands PO  1  (detail)  110
(76%)
C56.1 + 5.5
(-)
-280
(60%)
57.5 + 2.8
(-)
Negative
Giedraitis, 2009
Sweden (ULSAM) CL  1  (detail)  86
(0%)
C80.2
(72-85)
-404
(0%)
81.8
(80-84)
Negative
Golan, 2008
Poland CL  4  (detail)  407
(67%)
C76.1 + 4.4
(-)
-407
(67%)
70.8 + 5.7
(-)
Positive
Kamboh, 2005
USA CL  3  (detail)  978
(66%)
C72.7 + 6.4
(-)
77.7 + 6.3
(-)
808
(62%)
75.2 + 5.6
(-)
Positive
Slifer, 2005
USA CL  7  (detail)  546
(-)
M70.8 + 6.6
(51-87)
-1005
(-)
-Positive
Slifer, 2006
Overlaps with
Slifer, 2005
CL  7  (detail)  546
(67%)
M70.8 + 6.6
(51-87)
-1005
(-)
72.3 + 6.5
(61-91)
Negative
Smemo, 2005
USA (WashU) CL  7  (detail)  376
(65%)
M76.2 + 6.8
(-)
-353
(62%)
77.5 + 7.4
(-)
Negative
Smemo, 2005
UK (MRC) CL  1  (detail)  633
(76%)
M77 + 6.1
(-)
-731
(67%)
76.6 + 5.9
(-)
Negative
Smemo, 2005
USA (UCSD) CL  1  (detail)  179
(49%)
M73.4 + 5.4
(-)
-330
(63%)
79.3 + 7.2
(-)
Negative
Smemo, 2005
UK (Brain) CL  1  (detail)  160
(66%)
N-81.4 + 6.8
(-)
112
(51%)
77.7 + 8
(-)
Negative
Smemo, 2005
USA (Brain) CL  1  (detail)  196
(57%)
N-81.7 + 6.8
(-)
116
(46%)
80 + 9
(-)
Negative
 Asian
Chuo, 2010
Taiwan CL  1  (detail)  100
(54%)
C-77.9 + 5.2
(65-92)
100
(-)
-Negative
Contact us if you are an author of an association study regarding this gene and do not find your study in this table or find errors in the representation of your study details.
2. Family-Based Studies (by ethnic group)
      Affecteds Unaffecteds    
Study Population # Polys # Families # Subjects
(% women)
DX Onset Age
(range)
Age
(range)
# Subjects
(% women)
Age
(range)
Result Comment
 Caucasian
Arias-Vasquez, 2007
Netherlands (GRIP)  1  (detail)   123
(-)
C--58
(-)
-Negative
Slifer, 2005
USA (CAP)  7  (detail)  288-U71.1 + 7
(-)
---Positive
Slifer, 2006
Overlaps with
Slifer, 2005
 7  (detail)  288-M71.7 + 7
(50-89)
--74.8 + 11.8
(61-91)
Negative
 Other/Mixed
Bertram, 2005
USA (NIMH)  5  (detail)  437994
(-)
M72.4 + 7.7
(50-97)
-411
(-)
-Positive
Bertram, 2005
USA (CAG)  4  (detail)  217224
(-)
M71.2 + 9.1
(50-89)
-265
(-)
-Positive
Bertram, 2005
USA (NIMH)  1  (detail)  437994
(-)
M72.4 + 7.7
(50-97)
-411
(-)
-Positive
Bertram, 2005
USA (CAG)  1  (detail)  217224
(-)
M71.2 + 9.1
(50-89)
-265
(-)
-Positive
Contact us if you are an author of an association study regarding this gene and do not find your study in this table or find errors in the representation of your study details.
Source:  Source of case population -> “CL” (clinic-based), “PO” (population-based), or “CO” (community-based).
# Polys:  Number of polymorphisms tested per gene and per sample.
Onset Age and Age:  Mean or median age at onset or examination, respectively.
DX:  Criteria used to determine AD diagnosis ->  "C" (clinical AD diagnosis), "N" (neuropathological AD diagnosis), "M" (mixed, i.e. AD sample contains both clinical and neuropathological cases), "U" (unknown).
Result:  Overall conclusion reached by authors of the original publication (“positive” usually indicates significant (P<0.05) association in at least one of the performed analyses, and “negative” indicates no evidence for significant association, while “trend” indicates results in between); results obtained in duplicate or largely overlapping samples are listed as "n.a.".
(-) :  Either no data provided or in case of overlap, data included in original study.
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Studies: 1395
Genes: 695
Polymorphisms: 2973
Meta-analyses: 320
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