AlzGene - Gene overview of all published AD-association studies for BDNF
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 Gene: BDNF  (MGC34632)  Entrez Gene    View on MSGene   View on PDGene   View on SZGene
 Protein: brain-derived neurotrophic factor  (neurotrophin)  ProteinLink
 Chromosome: 11   (View: 1  2  3  4  5  6  7  8  9  10  11  12  13  14  15  16  17  18  19  20  21  22  X  Y  MT)
 Status: Updated 18 April 2011
Meta-Analysis
1. Case-Control Studies (by ethnic group)
      AD Cases Normal Controls    
Study Population Source # Polys # Subjects
(% women)
DX Onset Age
(range)
Age
(range)
# Subjects
(% women)
Age
(range)
Result Comment
 Caucasian
Bagnoli, 2004
Italy CL  2  (detail)  128
(65%)
C65.7 + 8.6
(-)
71.1 + 8.5
(-)
97
(63%)
72.9 + 24
(-)
Negative
Bodner, 2005
USA CL  3  (detail)  256
(62%)
N77 + 8.2
(63-99)
83 + 7.1
(-)
194
(54%)
81 + 7.7
(-)
Negative
Combarros, 2004
Spain CL,CO  1  (detail)  237
(68%)
C71.6 + 9
(48-95)
75.3 + 9.2
(50-98)
218
(71%)
79.9 + 7.9
(63-98)
Negative
Cousin, 2009
France CL  1  (detail)  428
(-)
C64.9 + 9.9
(-)
-475
(-)
66.2 + 10.8
(-)
Negative
Cozza, 2008
Italy CL  6  (detail)  251
(62%)
C65.2 + 8.6
(-)
-97
(53%)
64.2 + 13.8
(-)
Trend
Desai, 2005
USA CL  2  (detail)  995
(67%)
C72.3 + 6.3
(-)
-671
(61%)
75.7 + 5.3
(-)
Negative
Feher, 2009
Hungary CL  1  (detail)  160
(64%)
C-73.7 + 9.5
(-)
164
(62%)
71.7 + 8.5
(-)
Positive
Fukumoto, 2010
Japan CL  2  (detail)  657
(65%)
C-73.5 + 8.7
(-)
525
(58%)
67.1 + 10.3
(-)
Positive
Giedraitis, 2009
Sweden (ULSAM) CL  3  (detail)  86
(0%)
C80.2
(72-85)
-404
(0%)
81.8
(80-84)
Negative
Gruenblatt, 2008
Austria PO  1  (detail)  127
(61%)
C--479
(59%)
-Negative
Huang, 2007
USA CL  7  (detail)  220
(70%)
C71 + 8
(50-92)
-128
(59%)
72 + 8
(50-88)
Positive
Li, 2005
USA (UCSD) CL  1  (detail)  188
(-)
C--361
(-)
-Negative
Li, 2005
USA (WashU) CL  1  (detail)  388
(-)
C--349
(-)
-Negative
Li, 2005
UK CL  1  (detail)  359
(-)
C--396
(-)
-Negative
Li, 2008
Canada CL  2  (detail)  753
(58%)
C71.9 + 8.5
(-)
77.8 + 8.6
(-)
736
(64%)
73.4 + 7.9
(-)
Negative
Nacmias, 2004
Italy CL  1  (detail)  83
(70%)
C68.5 + 7.3
(-)
72.2 + 7
(-)
97
(63%)
72.9 + 24
(-)
Negative
Nishimura, 2004
Brazil CL  1  (detail)  188
(66%)
C-68.7 + 8
(-)
188
(66%)
72.3 + 9.8
(-)
Negative
Olin, 2005
USA CL  1  (detail)  212
(50%)
N-77.7 + 9.1
(51-100)
202
(44%)
66 + 8.1
(55-96)
Positive
Reiman, 2007
USA, Netherlands CL  2  (detail)  861
(-)
M-74.9 + 6.6
(-)
550
(-)
77.4 + 7.3
(-)
Negative
Riemenschneider, 2002
Germany CL  1  (detail)  210
(61%)
C-69.3 + 10.4
(-)
188
(64%)
65.6 + 13.8
(-)
Positive
Saarela, 2006
Finland CL  2  (detail)  97
(70%)
M--101
(55%)
79 + 9.3
(-)
Negative
Ventriglia, 2002
Italy CL  1  (detail)  130
(69%)
C-72 + 3
(-)
111
(-)
-Positive
Vepsalainen, 2005
Finland CL  5  (detail)  375
(69%)
C72 + 7
(43-90)
-460
(60%)
70 + 5
(60-87)
Negative
Webster, 2010
Overlaps with
Reiman, 2007
CL  1  (detail)  861
(-)
M-82.8 + 7.7
(-)
550
(-)
79.7 + 6.3
(-)
Negative 
Zhang, 2006
USA CL  3  (detail)  295
(61%)
C-69.1 + 8.1
(-)
250
(59%)
37.5 + 19.7
(-)
Negative
 African Descent
Desai, 2005
USA CL  2  (detail)  65
(72%)
C72.3 + 6.3
(-)
-45
(73%)
70.5 + 5.7
(-)
Negative
 Asian
Akatsu, 2006
Japan CL  2  (detail)  95
(61%)
N-83.5 + 7.5
(-)
108
(81%)
81.6 + 7
(70-101)
Negative
Bian, 2005
China CL  1  (detail)  203
(53%)
C68.1 + 9.2
(40-89)
-239
(44%)
70.2 + 7.5
(48-90)
Positive
He, 2007
China CL  1  (detail)  513
(62%)
C70.8 + 9.2
(-)
75.7 + 9.8
(46-99)
575
(58%)
70.1 + 8.1
(46-96)
Negative
Kunugi, 2001
Japan CL  1  (detail)  170
(65%)
C-73.8 + 6
(-)
499
(22%)
55 + 9.1
(-)
Positive
Matsushita, 2005
Japan CL  2  (detail)  487
(70%)
C-76.1 + 8.9
(-)
471
(68%)
75.2 + 6.1
(-)
Positive
Nishimura, 2005
Japan    2  (detail)  172
(60%)
U-77.4 + 9.7
(55-96)
275
(61%)
68.4 + 10.5
(35-92)
Positive
Tsai, 2004
Overlaps with
Tsai, 2006
CL  1  (detail)  ------n.a.
Tsai, 2006
China CL  2  (detail)  175
(48%)
C-74.9 + 6.1
(-)
189
(53%)
73.7 + 7.6
(-)
Positive
 Hispanic
Forero, 2006
Colombia CL  1  (detail)  102
(70%)
C68.8 + 8.7
(-)
73.3 + 8.8
(-)
168
(58%)
71.8 + 7.2
(-)
Trend
 Other/Mixed
Lee, 2005
USA CL  2  (detail)  116
(67%)
N-80.4 + 0.8
(-)
77
(55%)
75 + 1
(-)
Negative
Contact us if you are an author of an association study regarding this gene and do not find your study in this table or find errors in the representation of your study details.
2. Family-Based Studies (by ethnic group)
      Affecteds Unaffecteds    
Study Population # Polys # Families # Subjects
(% women)
DX Onset Age
(range)
Age
(range)
# Subjects
(% women)
Age
(range)
Result Comment
 Other/Mixed
Schjeide, 2009
USA (CAG)  1  (detail)  217222
(59%)
M69.2 + 9
(50-89)
-267
(63%)
72.9 + 8.8
(49-92)
Negative
Schjeide, 2009
USA (NCRAD)  1  (detail)  340741
(74%)
M71.3 + 7.6
(50-98)
-300
(55%)
71 + 8.4
(39-93)
Positive
Schjeide, 2009
USA (NIA)  1  (detail)  351803
(64%)
M74.1 + 7.1
(52-98)
-290
(59%)
73.3 + 9.5
(36-94)
Negative
Schjeide, 2009
USA (NIMH)  1  (detail)  436995
(74%)
M72.4 + 7.7
(50-97)
-411
(58%)
70 + 10.7
(31-93)
Negative
Contact us if you are an author of an association study regarding this gene and do not find your study in this table or find errors in the representation of your study details.
Source:  Source of case population -> “CL” (clinic-based), “PO” (population-based), or “CO” (community-based).
# Polys:  Number of polymorphisms tested per gene and per sample.
Onset Age and Age:  Mean or median age at onset or examination, respectively.
DX:  Criteria used to determine AD diagnosis ->  "C" (clinical AD diagnosis), "N" (neuropathological AD diagnosis), "M" (mixed, i.e. AD sample contains both clinical and neuropathological cases), "U" (unknown).
Result:  Overall conclusion reached by authors of the original publication (“positive” usually indicates significant (P<0.05) association in at least one of the performed analyses, and “negative” indicates no evidence for significant association, while “trend” indicates results in between); results obtained in duplicate or largely overlapping samples are listed as "n.a.".
(-) :  Either no data provided or in case of overlap, data included in original study.
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Studies: 1395
Genes: 695
Polymorphisms: 2973
Meta-analyses: 320
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