AlzGene - Gene overview of all published AD-association studies for NOS3
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 Gene: NOS3   Entrez Gene    View on ALSGene   View on MSGene   View on PDGene   View on SZGene
 Protein: nitric oxide synthase 3 (endothelial cell)   ProteinLink
 Chromosome: 7   (View: 1  2  3  4  5  6  7  8  9  10  11  12  13  14  15  16  17  18  19  20  21  22  X  Y  MT)
 Status: Updated 18 April 2011
Meta-Analysis
1. Case-Control Studies (by ethnic group)
      AD Cases Normal Controls    
Study Population Source # Polys # Subjects
(% women)		 DX Onset Age
(range)		 Age
(range)		 # Subjects
(% women)		 Age
(range)		 Result Comment
 Caucasian
Akomolafe, 2006
 Mixed CL  11  (detail)  259
(66%)		M-68.3 + 9
(-)		127
(41%)		71.7 + 9.3
(-)		Trend
Alvarez, 1999
 Spain CL  1  (detail)  350
(56%)		C-72 + 9
(-)		517
(-)		-Negative
Blomqvist, 2005
 Overlaps with
Emahazion, 2001		 CL  1  (detail)  121
(58%)		C-57.8 + 6.3
(-)		165
(37%)		58.3 + 9.9
(-)		n.a.
Blomqvist, 2005
 Sweden CL  1  (detail)  819
(63%)		M-76.2 + 7.1
(-)		240
(59%)		73.2 + 9.3
(-)		Negative
Corder, 2008
 Overlaps with
Blomqvist, 2005		 CL  1  (detail)  938
(-)		U--397
(-)		-n.a.
Emahazion, 2001
 Scotland CL  1  (detail)  121
(-)		C--152
(-)		-Negative
Giedraitis, 2009
 Sweden (ULSAM) CL  7  (detail)  86
(0%)		C80.2
(72-85)		-404
(0%)		81.8
(80-84)		Negative
Guidi, 2005
 Italy CL  1  (detail)  405
(70%)		C73
(-)		-253
(58%)		71
(48-98)		Positive
Hamilton, 2007
 UK (I) CL  3  (detail)  258
(76%)		C76.4 + 7.2
(-)		82.9 + 6.5
(-)		275
(56%)		79.5 + 4.5
(-)		Negative
Kalman, 2003
 Hungary CL  1  (detail)  51
(69%)		C-76 + 10.1
(-)		51
(53%)		72 + 7
(-)		Negative
Li, 2008
 Canada CL  1  (detail)  753
(58%)		C71.9 + 8.5
(-)		77.8 + 8.6
(-)		736
(64%)		73.4 + 7.9
(-)		Negative
Monastero, 2003
 Italy CL  1  (detail)  70
(11%)		C69.7 + 7.7
(50-85)		72 + 9.7
(51-89)		149
(62%)		73.3 + 7.6
(54-89)		Negative
Prince, 2001
 Overlaps with
Blomqvist, 2005		 CL  1  (detail)  204
(61%)		M--186
(58%)		-n.a.
Randall, 2009
 USA CL  2  (detail)  181
(71%)		C--119
(52%)		-Positive
Reiman, 2007
 USA, Netherlands CL  1  (detail)  861
(-)		M-74.9 + 6.6
(-)		550
(-)		77.4 + 7.3
(-)		Negative
Sanchez-Guerra, 2001
 Spain CL  1  (detail)  301
(66%)		C71.5 + 8.9
(40-95)		75.2 + 9
(50-98)		309
(71%)		80.3 + 7.7
(63-99)		Negative
Styczynska, 2003
 Overlaps with
Styczynska, 2008		 CL  1  (detail)  100
(66%)		C71 + 4.6
(-)		76.4 + 4.7
(-)		100
(58%)		74.2 + 6.6
(-)		n.a.
Styczynska, 2008
 Poland CL  1  (detail)  154
(66%)		C71.5 + 4.6
(-)		-176
(68%)		72.7 + 6.2
(-)		Positive
Tedde, 2002
 Italy CL  1  (detail)  252
(-)		C65 + 7.3
(-)		-95
(58%)		80.8 + 24.5
(26-108)		Negative
Venturelli, 2005
 Italy CL  1  (detail)  432
(70%)		C-73 + 7.9
(-)		360
(64%)		72 + 8.1
(-)		Negative
 African Descent
Akomolafe, 2006
 USA CL  11  (detail)  235
(76%)		M-71.4 + 8.1
(-)		82
(70%)		72.3 + 7.2
(-)		Positive
 Asian
Higuchi, 2000
 Japan CL  1  (detail)  411
(73%)		C-76 + 8.5
(-)		350
(72%)		75.7 + 5.2
(-)		Negative
Kunugi, 2000
 Japan CL  1  (detail)  171
(66%)		C-74.1 + 6
(-)		165
(59%)		57 + 8
(-)		Negative
Wang, 2008
 China CL  1  (detail)  338
(42%)		C-77.6 + 6.7
(65-92)		378
(42%)		72.9 + 5.5
(65-89)		Positive
 Other/Mixed
Crawford, 2000
 USA CL,PO  1  (detail)  287
(67%)		C73
(-)		-120
(58%)		73.3
(-)		Negative
Dahiyat, 1999
 UK CL,CO  1  (detail)  439
(59%)		M--392
(52%)		-Positive
Singleton, 2001
 UK CL  1  (detail)  158
(66%)		N-79.1 + 0.7
(57-98)		111
(52%)		78.2 + 0.8
(66-100)		Negative
Contact us if you are an author of an association study regarding this gene and do not find your study in this table or find errors in the representation of your study details.
2. Family-Based Studies (by ethnic group)
      Affecteds Unaffecteds    
Study Population # Polys # Families # Subjects
(% women)		 DX Onset Age
(range)		 Age
(range)		 # Subjects
(% women)		 Age
(range)		 Result Comment
 Caucasian
Akomolafe, 2006
 Overlaps with
case-control sample		  11  (detail)   259
(66%)		M-68.3 + 9
(-)		127
(41%)		71.7 + 9.3
(-)		Trend
 African Descent
Akomolafe, 2006
 Overlaps with
case-control sample		  11  (detail)   241
(77%)		M-71.4 + 8.1
(-)		226
(67%)		72.7 + 9.4
(-)		Positive
Contact us if you are an author of an association study regarding this gene and do not find your study in this table or find errors in the representation of your study details.
Source:  Source of case population -> “CL” (clinic-based), “PO” (population-based), or “CO” (community-based).
# Polys:  Number of polymorphisms tested per gene and per sample.
Onset Age and Age:  Mean or median age at onset or examination, respectively.
DX:  Criteria used to determine AD diagnosis ->  "C" (clinical AD diagnosis), "N" (neuropathological AD diagnosis), "M" (mixed, i.e. AD sample contains both clinical and neuropathological cases), "U" (unknown).
Result:  Overall conclusion reached by authors of the original publication (“positive” usually indicates significant (P<0.05) association in at least one of the performed analyses, and “negative” indicates no evidence for significant association, while “trend” indicates results in between); results obtained in duplicate or largely overlapping samples are listed as "n.a.".
(-) :  Either no data provided or in case of overlap, data included in original study.
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Studies: 1395
Genes: 695
Polymorphisms: 2973
Meta-analyses: 320
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