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AlzGene - Gene overview of all published AD-association studies for SERPINA3
Gene:
SERPINA3
(ACT; AACT; GIG24; GIG25)
View on PDGene
View on SZGene
Protein:
serpin peptidase inhibitor, clade A, member 3
(antichymotrypsin; alpha-1-antichymotrypsin)
Chromosome:
14
(View:
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
X
Y
MT
)
Status:
Updated 18 April 2011
1. Case-Control Studies (by ethnic group)
AD Cases
Normal Controls
Study
Population
Source
# Polys
# Subjects
(% women)
DX
Onset Age
(range)
Age
(range)
# Subjects
(% women)
Age
(range)
Result
Comment
Caucasian
Bass, 1998
USA
CL
1
(detail)
284
(57%)
C
67.1 + 8.5
(40-85)
72.1 + 7.9
(42-93)
171
(56%)
69.3 + 7.9
(37-86)
Negative
Belbin, 2007
UK
CL
5
(detail)
668
(44%)
M
69.8 + 12
(-)
-
419
(51%)
68 + 15.7
(-)
Negative
Christie, 1996
Overlaps with
Lamb, 1998
CL
1
(detail)
109
(-)
N
-
77.8 + 9.3
(46-94)
101
(-)
76 + 8.9
(59-104)
n.a.
Clarimon, 2003
Spain
CL
1
(detail)
112
(73%)
C
-
76.7 + 5.4
(-)
89
(53%)
74.8 + 5.2
(-)
Negative
DeKosky, 1996
Overlaps with
Kamboh, 1995
CL,PO
1
(detail)
-
U
-
-
-
-
n.a.
Didierjean, 1997
France
CL
1
(detail)
314
(70%)
C
66.7 + 11.8
(-)
-
173
(53%)
61.7 + 10.1
(-)
Negative
Durany, 1998
Germany
CL
2
(detail)
56
(54%)
N
-
72.4 + 9.2
(55-95)
70
(47%)
72.2 + 8.8
(55-95)
Negative
Durany, 1999
Germany
CL
1
(detail)
63
(67%)
C
-
74.7 + 9.3
(46-90)
65
(60%)
71.7 + 8.5
(48-92)
Negative
Durany, 2000
Overlaps with
Durany, 1999
1
(detail)
-
U
-
-
-
-
n.a.
Egensperger, 1997
Germany
CL
1
(detail)
28
(75%)
N
-
78.1
(-)
100
(54%)
74.3
(-)
Negative
Emahazion, 2001
Scotland
CL
1
(detail)
121
(-)
C
-
-
152
(-)
-
Negative
Ezquerra, 1998
Spain
CL
1
(detail)
136
(-)
U
-
64.4 + 9.6
(-)
92
(-)
67 + 11.8
(-)
Positive
Giedraitis, 2009
Sweden (ULSAM)
CL
2
(detail)
86
(0%)
C
80.2
(72-85)
-
404
(0%)
81.8
(80-84)
Negative
Helisalmi, 1997
Finland
CL
1
(detail)
218
(67%)
C
-
78 + 9
(-)
101
(84%)
71 + 10
(-)
Negative
Itabashi, 1998
USA
CL
1
(detail)
86
(-)
N
-
77.9
(59-92)
29
(-)
64.2
(18-92)
Negative
Kamboh, 1995
USA
CL
1
(detail)
225
(64%)
M
-
74.6
(22-101)
315
(69%)
53
(24-92)
Positive
Lamb, 1998
UK
CL
1
(detail)
108
(-)
N
-
77.8 + 9.3
(46-94)
101
(-)
76 + 8.9
(59-104)
Trend
Li, 2008
Canada
CL
1
(detail)
753
(58%)
C
71.9 + 8.5
(-)
77.8 + 8.6
(-)
736
(64%)
73.4 + 7.9
(-)
Negative
Licastro, 1999
Italy
CL
1
(detail)
260
(61%)
C
-
73.8 + 1
(-)
186
(33%)
60 + 1
(50-92)
Positive
Licastro, 2000
Overlaps with
Licastro, 1999
1
(detail)
-
-
-
-
-
-
n.a.
Licastro, 2005
Italy
CL
1
(detail)
422
(-)
C
-
74 + 8
(-)
433
(-)
67 + 12
(-)
Positive
Licastro, 2005
UK
CL
1
(detail)
19
(-)
N
-
59 + 7.1
(-)
28
(-)
62 + 2
(-)
Positive
Licastro, 2006
Overlaps with
Licastro, 1999 & 2005
CL
2
(detail)
260
(-)
C
-
-
190
(-)
-
n.a.
McIlroy, 2000
Ireland
CL
1
(detail)
108
(67%)
C
74.4
(-)
78 + 6.1
(65-90)
108
(67%)
78.3 + 5.9
(65-90)
Positive
Morgan, 1997
Unknown
CL
2
(detail)
195
(-)
N
-
80.8 + 9.8
(55-101)
126
(-)
72.8 + 9
(58-91)
Positive
Muller, 1996
Germany
CL
1
(detail)
147
(-)
U
-
-
74
(-)
-
Negative
Nacmias, 1996
Italy
CL
1
(detail)
100
(-)
C
57.4 + 4.5
(-)
-
103
(-)
74.5 + 25.1
(19-106)
Negative
Nacmias, 1998
Overlaps with
Nacmias, 1998
1
(detail)
-
U
-
-
-
-
Negative
Papassotiropoulos, 2003
Europe (mixed)
CL
1
(detail)
153
(-)
C
-
-
181
(-)
-
Negative
Reiman, 2007
USA, Netherlands
CL
1
(detail)
861
(-)
M
-
74.9 + 6.6
(-)
550
(-)
77.4 + 7.3
(-)
Negative
Retz, 2001
Germany
CL
1
(detail)
63
(68%)
C
66.6 + 11.9
(-)
73.7 + 9.3
(-)
162
(62%)
70.6 + 8.2
(-)
Negative
Rodriguez, 2000
Israel
CL
1
(detail)
121
(64%)
C
-
73.2
(-)
125
(68%)
79.6
(-)
Negative
Scacchi, 1999
Italy
CO
1
(detail)
85
(76%)
C
-
86.1 + 3.8
(81-95)
156
(58%)
83.8 + 3.2
(74-99)
Trend
Scacchi, 2001
Overlaps with
Scacchi, 1999
1
(detail)
-
U
-
-
-
-
n.a.
Talbot, 1996
Unknown
1
(detail)
202
(60%)
U
69.9 + 8.6
(44-92)
76.6 + 9.6
(-)
133
(59%)
75.5 + 12.2
(-)
Negative
Thome, 1995
Germany
1
(detail)
17
(47%)
C
-
-
58
(-)
-
Positive
Wang, 1998
Overlaps with
Kamboh, 1995
1
(detail)
-
U
-
-
-
-
n.a.
Wang, 2002 (I)
Overlaps with
Kamboh, 1995
CL
7
(detail)
567
(68%)
M
71.2 + 6.1
(-)
77.4 + 6.4
(-)
319
(68%)
73.9 + 5
(-)
n.a.
Wang, 2002 (II)
Overlaps with
Kamboh, 1995
7
(detail)
-
U
-
-
-
-
n.a.
African Descent
Perry, 2001
USA
CL
1
(detail)
111
(78%)
M
70.8 + 7.8
(-)
71.3 + 7.7
(-)
78
(76%)
75.2 + 7.6
(-)
Negative
Asian
Hu, 2000
Taiwan
CL
1
(detail)
82
(-)
C
-
78.2
(62-96)
110
(-)
79.2
(67-87)
Negative
Ki, 2001
Korea
CL
1
(detail)
89
(78%)
C
73.1 + 5.8
(-)
-
50
(58%)
73.2 + 7.8
(-)
Negative
Kim, 2000
Korea
CL
1
(detail)
110
(-)
C
-
70 + 7.8
(-)
209
(-)
68.2 + 4.6
(-)
Negative
Kim, 2000
Overlaps with
Kim, 2000
1
(detail)
-
U
-
-
-
-
n.a.
Meng, 2000
China
CL
2
(detail)
33
(48%)
C
68.4 + 8.9
(49-87)
73 + 9.8
(51-96)
246
(46%)
75.8 + 7.9
(60-93)
Positive
Muramatsu, 1996
Japan
CL
2
(detail)
101
(68%)
C
-
76 + 8.9
(-)
104
(47%)
73 + 9.2
(-)
Positive
Sodeyama, 1999
Overlaps with
Yamada, 2002
1
(detail)
-
U
-
-
-
-
n.a.
Tang, 2000
China
CL
1
(detail)
125
(49%)
C
70.6 + 8.6
(50-89)
-
140
(57%)
52 + 18.6
(30-81)
Negative
Wang, 1999
China
CL
1
(detail)
157
(43%)
C
-
72.8 + 8.7
(-)
114
(39%)
72.9 + 3.5
(-)
Negative
Yamada, 1998
Overlaps with
Yamada, 2002
1
(detail)
-
U
-
-
-
-
n.a.
Yamada, 2002
Japan
CL
1
(detail)
82
(-)
N
-
86.1 + 7.9
(62-104)
119
(-)
85.7 + 8
(65-103)
Negative
Yamanaka, 1998
Japan
1
(detail)
65
(68%)
C
51
(-)
-
200
(-)
-
Negative
Yoshiiwa, 1997
Japan
CL
1
(detail)
139
(69%)
C
74.2 + 7.1
(65-94)
79 + 6.8
(66-98)
250
(64%)
79.8 + 7.9
(65-101)
Positive
Yoshizawa, 1997
Japan
CL
1
(detail)
82
(78%)
M
-
74.1 + 10
(47-95)
277
(-)
49.3 + 8.6
(29-75)
Negative
Yu, 2010
China
CL
4
(detail)
244
(57%)
C
70 + 9.5
(-)
74.9 + 8.3
(-)
205
(56%)
69.6 + 10.6
(-)
Negative
Other/Mixed
Fallin, 1997
USA & UK
CL,PO
1
(detail)
93
(-)
C
72.9 + 7.4
(-)
-
112
(-)
73 + 7.1
(-)
Negative
Haines, 1996 (I)
USA
CL
1
(detail)
576
(63%)
C
69.1 + 8.6
(-)
-
535
(-)
-
Negative
Haines, 1996 (II)
Same as Haines, 1996 (I)
1
(detail)
-
U
-
-
-
-
n.a.
Murphy, 1997
USA
CL
1
(detail)
160
(44%)
M
65.8 + 8
(42-86)
74.4 + 8.1
(47-96)
142
(60%)
60 + 17.1
(20-87)
Negative
Contact us
if you are an author of an association study regarding this gene and do not find your study in this table or find errors in the representation of your study details.
Source:
Source of case population -> “CL” (clinic-based), “PO” (population-based), or “CO” (community-based).
# Polys:
Number of polymorphisms tested per gene and per sample.
Onset Age and Age:
Mean or median age at onset or examination, respectively.
DX:
Criteria used to determine AD diagnosis -> "C" (clinical AD diagnosis), "N" (neuropathological AD diagnosis), "M" (mixed, i.e. AD sample contains both clinical and neuropathological cases), "U" (unknown).
Result:
Overall conclusion reached by authors of the original publication (“positive” usually indicates significant (P<0.05) association in at least one of the performed analyses, and “negative” indicates no evidence for significant association, while “trend” indicates results in between); results obtained in duplicate or largely overlapping samples are listed as "n.a.".
(-)
: Either no data provided or in case of overlap, data included in original study.
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