AlzGene - Gene overview of all published AD-association studies for SLC6A4
Back Search Methods Disclaimer Credits
 Gene: SLC6A4  (HTT; OCD1; SERT; 5-HTT; hSERT; 5HTT)  Entrez Gene    View on PDGene   View on SZGene
 Protein: solute carrier family 6, member 4  (serotonin transporter)  ProteinLink
 Chromosome: 17   (View: 1  2  3  4  5  6  7  8  9  10  11  12  13  14  15  16  17  18  19  20  21  22  X  Y  MT)
 Status: Updated 5 January 2011
Meta-Analysis
1. Case-Control Studies (by ethnic group)
      AD Cases Normal Controls    
Study Population Source # Polys # Subjects
(% women)
DX Onset Age
(range)
Age
(range)
# Subjects
(% women)
Age
(range)
Result Comment
 Caucasian
Gruenblatt, 2008
Austria PO  1  (detail)  127
(61%)
C--479
(59%)
-Negative
Hu, 2000
Germany CL  1  (detail)  50
(-)
C--199
(-)
-Positive
Li, 1997
UK CL  2  (detail)  196
(-)
C-82.5 + 6.7
(-)
271
(-)
-Negative
Lorenzi, 2010
Italy CL  1  (detail)  164
(71%)
C71.6 + 8.7
(-)
75.4 + 8.2
(-)
54
(48%)
66.7 + 6.9
(-)
Positive
Micheli, 2006
Italy CL  1  (detail)  208
(63%)
C-71.8 + 9.5
(-)
116
(50%)
70.8 + 4.6
(-)
Negative
Rocchi, 2003
Overlaps with
Micheli, 2006
CL  1  (detail)  135
(67%)
C72.4 + 7.8
(-)
-90
(-)
70.2 + 9.1
(-)
n.a.
Seripa, 2008
Italy CL  1  (detail)  105
(68%)
C-78.4 + 7.5
(-)
114
(39%)
75.7 + 7
(-)
Negative
Zill, 2000
Germany CL  1  (detail)  84
(57%)
C-73 + 9
(-)
118
(53%)
47 + 12
(-)
Negative
 Asian
Ha, 2005
Korea CL  1  (detail)  65
(58%)
C-74.9 + 6.9
(-)
43
(-)
73.1 + 3.8
(-)
Negative
Kunugi, 2000
Japan CL  1  (detail)  123
(72%)
C-73.1 + 6.4
(-)
336
(55%)
49.8 + 10.5
(-)
Negative
Tsai, 2001
Taiwan CL  1  (detail)  136
(44%)
C-72.6 + 5.2
(-)
83
(51%)
71.5 + 6.4
(-)
Negative
 Hispanic
Forero, 2005
Colombia CL  1  (detail)  106
(71%)
C68.8 + 8.7
(-)
73.3 + 8.8
(-)
97
(-)
72.2 + 8.7
(-)
Negative
 Other/Mixed
Nishimura, 2005
Brazil    1  (detail)  128
(64%)
C-70.7 + 9
(-)
126
(64%)
70.9 + 9.1
(-)
Positive
Oliviera, 1998
Overlaps with
Nishimura, 2005
   1  (detail)  ------n.a.
Oliviera, 1999
Overlaps with
Nishimura, 2005
   1  (detail)  ------n.a.
Contact us if you are an author of an association study regarding this gene and do not find your study in this table or find errors in the representation of your study details.
Source:  Source of case population -> “CL” (clinic-based), “PO” (population-based), or “CO” (community-based).
# Polys:  Number of polymorphisms tested per gene and per sample.
Onset Age and Age:  Mean or median age at onset or examination, respectively.
DX:  Criteria used to determine AD diagnosis ->  "C" (clinical AD diagnosis), "N" (neuropathological AD diagnosis), "M" (mixed, i.e. AD sample contains both clinical and neuropathological cases), "U" (unknown).
Result:  Overall conclusion reached by authors of the original publication (“positive” usually indicates significant (P<0.05) association in at least one of the performed analyses, and “negative” indicates no evidence for significant association, while “trend” indicates results in between); results obtained in duplicate or largely overlapping samples are listed as "n.a.".
(-) :  Either no data provided or in case of overlap, data included in original study.
AlzGene Recent Updates
AlzGene Top Results
AlzGene Stats
Studies: 1395
Genes: 695
Polymorphisms: 2973
Meta-analyses: 320
Cure Alzheimer's Fund
Proud supporter of the AlzGene database.
Michael J. Fox Foundation
The PDGene database is supported by a grant from The Michael J. Fox Foundation in partnership with the Alzheimer Research Forum.

NCRAD

The National Cell Repository for Alzheimer Disease seeks to recruit 1,000 families with two or more living brothers or sisters who have been diagnosed with late onset Alzheimer’s disease.
ALSGene
AlzGene
MSGene
PDGene
SZGene
An up-to-date collection of all published genetic association studies.