AlzGene - Gene overview of all published AD-association studies for SORCS1
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 Gene: SORCS1   Entrez Gene
 Protein: sortilin-related VPS10 domain containing receptor 1   ProteinLink
 Chromosome: 10   (View: 1  2  3  4  5  6  7  8  9  10  11  12  13  14  15  16  17  18  19  20  21  22  X  Y  MT)
 Status: Updated 18 April 2011
Meta-Analysis
1. Case-Control Studies (by ethnic group)
      AD Cases Normal Controls    
Study Population Source # Polys # Subjects
(% women)
DX Onset Age
(range)
Age
(range)
# Subjects
(% women)
Age
(range)
Result Comment
 Caucasian
Grupe, 2006
USA (WashU) CL  1  (detail)  422
(-)
C--382
(-)
-Positive
Grupe, 2006
UK (MRC) CL  1  (detail)  368
(-)
C--404
(-)
-Trend
Grupe, 2006
USA (UCSD) CL  1  (detail)  217
(-)
C--409
(-)
-Negative
Grupe, 2006
Overlaps with
Schjeide, 2009
CL  1  (detail)  429
(-)
C73.6
(-)
-321
(-)
75
(-)
Negative
Li, 2008
Canada CL  2  (detail)  753
(58%)
C71.9 + 8.5
(-)
77.8 + 8.6
(-)
736
(64%)
73.4 + 7.9
(-)
Trend
Liang, 2009
USA CL  2  (detail)  506
(61%)
M72.5 + 6.3
(-)
75.9 + 12.1
(-)
558
(60%)
74.3 + 5.9
(-)
Positive
Reiman, 2007
USA, Netherlands CL  2  (detail)  861
(-)
M-74.9 + 6.6
(-)
550
(-)
77.4 + 7.3
(-)
Negative
Contact us if you are an author of an association study regarding this gene and do not find your study in this table or find errors in the representation of your study details.
2. Family-Based Studies (by ethnic group)
      Affecteds Unaffecteds    
Study Population # Polys # Families # Subjects
(% women)
DX Onset Age
(range)
Age
(range)
# Subjects
(% women)
Age
(range)
Result Comment
 Caucasian
Liang, 2009
USA  1  (detail)  7301521
(-)
C--974
(-)
-Positive
Rogaeva, 2007
Mixed (Northern European)  6  (detail)  124321
(-)
M70 + 9
(-)
-342
(-)
-Negative
 Hispanic
Rogaeva, 2007
USA, Caribbean  6  (detail)  228605
(-)
M73 + 11
(-)
-517
(-)
-Positive
 Other/Mixed
Schjeide, 2009
USA (CAG)  1  (detail)  217222
(59%)
M69.2 + 9
(50-89)
-267
(63%)
72.9 + 8.8
(49-92)
Negative
Schjeide, 2009
USA (NCRAD)  1  (detail)  340741
(74%)
M71.3 + 7.6
(50-98)
-300
(55%)
71 + 8.4
(39-93)
Negative
Schjeide, 2009
USA (NIA)  1  (detail)  351803
(64%)
M74.1 + 7.1
(52-98)
-290
(59%)
73.3 + 9.5
(36-94)
Negative
Schjeide, 2009
USA (NIMH)  1  (detail)  436995
(74%)
M72.4 + 7.7
(50-97)
-411
(58%)
70 + 10.7
(31-93)
Negative
Contact us if you are an author of an association study regarding this gene and do not find your study in this table or find errors in the representation of your study details.
Source:  Source of case population -> “CL” (clinic-based), “PO” (population-based), or “CO” (community-based).
# Polys:  Number of polymorphisms tested per gene and per sample.
Onset Age and Age:  Mean or median age at onset or examination, respectively.
DX:  Criteria used to determine AD diagnosis ->  "C" (clinical AD diagnosis), "N" (neuropathological AD diagnosis), "M" (mixed, i.e. AD sample contains both clinical and neuropathological cases), "U" (unknown).
Result:  Overall conclusion reached by authors of the original publication (“positive” usually indicates significant (P<0.05) association in at least one of the performed analyses, and “negative” indicates no evidence for significant association, while “trend” indicates results in between); results obtained in duplicate or largely overlapping samples are listed as "n.a.".
(-) :  Either no data provided or in case of overlap, data included in original study.
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Studies: 1395
Genes: 695
Polymorphisms: 2973
Meta-analyses: 320
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