AlzGene - Gene overview of all published AD-association studies for HLA
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 Gene: HLA   Entrez Gene
 Protein: major histocompatibility complex  (human leucocyte antigen)  ProteinLink
 Chromosome: 6   (View: 1  2  3  4  5  6  7  8  9  10  11  12  13  14  15  16  17  18  19  20  21  22  X  Y  MT)
 Status: Updated 11 February 2010 ;  ***Please note that the entry for this gene summarizes findings on various members of the HLA complex***
Meta-Analysis
1. Case-Control Studies (by ethnic group)
      AD Cases Normal Controls    
Study Population Source # Polys # Subjects
(% women)		 DX Onset Age
(range)		 Age
(range)		 # Subjects
(% women)		 Age
(range)		 Result Comment
 Caucasian
Araria-Goumidi, 2002
 France CL  1  (detail)  451
(61%)		C69.4 + 7.4
(-)		72.3 + 7.2
(-)		477
(64%)		72.5 + 7.9
(-)		Negative
Ballerini, 1999
 Italy CL  1  (detail)  78
(47%)		C55.5 + 7.8
(-)		66 + 7.8
(-)		563
(-)		-Positive
Curran, 1997
 UK CL  1  (detail)  78
(68%)		N-81
(71-93)		50
(62%)		80
(71-104)		Positive
Guerini, 2008
 Italy CL  1  (detail)  173
(64%)		C--258
(64%)		68.6 + 10.8
(-)		Negative
Harris, 2000
 UK CL  1  (detail)  172
(71%)		M67.6 + 6.2
(-)		-155
(48%)		61.1 + 6.5
(-)		Positive
Henschke, 1978
 Canada CL  1  (detail)  34
(56%)		C-78.9
(64-92)		239
(-)		-Negative
Lehmann, 2001
 Overlaps with
Lehmann, 2006		 CL  1  (detail)  55
(64%)		N-81.7
(-)		73
(59%)		79.3
(-)		Positive
Lehmann, 2001
 UK (II) CL  1  (detail)  143
(66%)		N-83.7
(-)		47
(28%)		76.3
(-)		Negative
Lehmann, 2001
 Canada CL  1  (detail)  101
(58%)		N-80.8
(-)		55
(38%)		76.6
(-)		Negative
Lehmann, 2006
 UK (OPTIMA) CL  1  (detail)  196
(56%)		M70.5 + 8.9
(-)		-199
(54%)		76.7 + 9.2
(-)		Positive
Listi, 2006
 Italy CL  1  (detail)  460
(47%)		---266
(55%)		-Positive
Majsky, 1983
 Czechoslovakia    1  (detail)  38
(95%)		U--301
(-)		-Negative
Middleton, 1999a
 Ireland CL  1  (detail)  107
(66%)		C-78 + 6.1
(-)		102
(66%)		78.3 + 5.9
(-)		Negative 
Middleton, 1999b
 UK CL  1  (detail)  95
(66%)		N-75.9
(41-93)		45
(53%)		80.5
(71-93)		Negative
Neill, 1999
 UK CL  1  (detail)  48
(-)		M--44
(-)		-Positive
Payami, 1991
 USA CL  1  (detail)  54
(26%)		C67.4 + 9
(49-84)		-263
(71%)		-Positive
Reed, 1983
 USA CL  1  (detail)  44
(-)		---100
(-)		-Negative
Reisner, 1983
 USA CL  1  (detail)  52
(73%)		C--305
(-)		-Negative
Renvoize, 1979
 Overlaps with
Renvoize, 1984		 CL  1  (detail)  124
(60%)		U63.2
(48-75)		-458
(-)		-n.a.
Renvoize, 1984
 UK CL  1  (detail)  124
(60%)		C68.7
(45-89)		-458
(-)		-Positive
Small, 1991
 Overlaps with
multiple studies		 CL  1  (detail)  167
(59%)		C--493
(-)		-n.a.
Small, 1999
 USA CL  1  (detail)  479
(62%)		C68.9 + 8.4
(40-88)		73.7 + 8
(42-93)		233
(53%)		70.4 + 8.5
(37-92)		Negative
Sulkava, 1980
 Finland CL  1  (detail)  32
(75%)		C-67.1
(50-74)		35
(69%)		71
(57-80)		Negative
Whalley, 1980
 UK    1  (detail)  14
(64%)		C56.7 + 7.2
(-)		62.3 + 8.4
(-)		64
(-)		-Negative
Wilcox, 1980
 UK CL  1  (detail)  18
(67%)		---342
(-)		-Positive
Wilcox, 1981
 Overlaps with
Wilcox, 1980		    1  (detail)  ------n.a.
 African Descent
Perry, 2001
 USA CL  1  (detail)  111
(78%)		M70.8 + 7.8
(-)		71.3 + 7.7
(-)		78
(76%)		75.2 + 7.6
(-)		Negative
 Asian
Endo, 1986
 Japan CL  1  (detail)  122
(-)		C-77.5
(41-96)		66
(-)		77.9
(54-100)		Positive
Ma, 2008
 China CL  1  (detail)  160
(82%)		C-78
(66-92)		167
(77%)		73
(65-88)		Positive
 Other/Mixed
Culpan, 2003
 USA & UK CL  1  (detail)  235
(64%)		N-80.7
(-)		130
(48%)		78.1
(-)		Positive
Small, 1986
 USA CL  1  (detail)  36
(58%)		C-70.1 + 9.1
(49-88)		25
(60%)		72.2 + 11.3
(56-94)		Positive
Contact us if you are an author of an association study regarding this gene and do not find your study in this table or find errors in the representation of your study details.
2. Family-Based Studies (by ethnic group)
      Affecteds Unaffecteds    
Study Population # Polys # Families # Subjects
(% women)		 DX Onset Age
(range)		 Age
(range)		 # Subjects
(% women)		 Age
(range)		 Result Comment
 Other/Mixed
Collins, 2000
 USA (NIMH)  1  (detail)  145311
(69%)		M69.4
(-)		-251
(64%)		72.5
(-)		Negative
Contact us if you are an author of an association study regarding this gene and do not find your study in this table or find errors in the representation of your study details.
Source:  Source of case population -> “CL” (clinic-based), “PO” (population-based), or “CO” (community-based).
# Polys:  Number of polymorphisms tested per gene and per sample.
Onset Age and Age:  Mean or median age at onset or examination, respectively.
DX:  Criteria used to determine AD diagnosis ->  "C" (clinical AD diagnosis), "N" (neuropathological AD diagnosis), "M" (mixed, i.e. AD sample contains both clinical and neuropathological cases), "U" (unknown).
Result:  Overall conclusion reached by authors of the original publication (“positive” usually indicates significant (P<0.05) association in at least one of the performed analyses, and “negative” indicates no evidence for significant association, while “trend” indicates results in between); results obtained in duplicate or largely overlapping samples are listed as "n.a.".
(-) :  Either no data provided or in case of overlap, data included in original study.
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AlzGene Stats
Studies: 1395
Genes: 695
Polymorphisms: 2973
Meta-analyses: 320
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NCRAD
The National Cell Repository for Alzheimer Disease seeks to recruit 1,000 families with two or more living brothers or sisters who have been diagnosed with late onset Alzheimer’s disease.
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