AlzGene - Gene overview of all published AD-association studies for SORL1
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 Gene: SORL1  (GP250; LR11; LRP9; SorLA; SorLA-1)  Entrez Gene
 Protein: Sortilin-related receptor  (Sorting protein-related receptor containing LDLR class A repeats; SorLA; Low-density lipoprotein receptor relative with 11 ligand-binding repeats; LR11)  ProteinLink
 Chromosome: 11   (View: 1  2  3  4  5  6  7  8  9  10  11  12  13  14  15  16  17  18  19  20  21  22  X  Y  MT)
 Status: Updated 18 April 2011
Meta-Analysis
1. Case-Control Studies (by ethnic group)
      AD Cases Normal Controls    
Study Population Source # Polys # Subjects
(% women)
DX Onset Age
(range)
Age
(range)
# Subjects
(% women)
Age
(range)
Result Comment
 Caucasian
Bettens, 2008
Belgium CL  29  (detail)  550
(70%)
C79 + 5.2
(-)
-634
(57%)
61.9 + 15.3
(-)
Positive
Cellini, 2009
Italy (Florence) CL  13  (detail)  251
(63%)
C71.8 + 5.2
(-)
-358
(69%)
83.4 + 17.9
(-)
Positive
Cousin, 2009
France CL  8  (detail)  516
(-)
C63.4 + 9.1
(-)
-539
(-)
67.3 + 10.9
(-)
Trend
Feulner, 2009
Germany CL  40  (detail)  491
(57%)
C-72.2
(-)
479
(46%)
39.5
(-)
Positive
Harold, 2009
GWAS (Stage 1) CL  1  (detail)  3941
(63%)
M72.7
(-)
79
(-)
7848
(53%)
55.6
(-)
Trend
Koelsch, 2009
Germany CL  4  (detail)  349
(61%)
C-71.9 + 8.2
(-)
483
(52%)
71.5
(-)
Positive
Lee, 2007
USA CO  29  (detail)  30
(80%)
C84.4 + 8
(-)
-76
(75%)
82.7 + 7.2
(-)
Positive
Li, 2007
UK1 CL  12  (detail)  343
(78%)
M75.8 + 6.9
(-)
-346
(75%)
76.4 + 6.1
(-)
Positive
Li, 2007
UK2 CL  12  (detail)  278
(73%)
M76.3 + 7.1
(-)
-311
(57%)
76.5 + 5.6
(-)
Negative
Li, 2007
USA (WashU) CL  12  (detail)  377
(64%)
M76.2 + 6.9
(-)
-376
(63%)
77.4 + 7.5
(-)
Negative
Li, 2008
Canada CL  17  (detail)  753
(58%)
C71.9 + 8.5
(-)
77.8 + 8.6
(-)
736
(64%)
73.4 + 7.9
(-)
Negative
Liu, 2009
Netherlands PO  7  (detail)  490
(68%)
-68.9 + 8.7
(-)
-6251
(59%)
-Negative
Meng, 2007
Re-analysis of Reiman, 2007 CL  0  -M----n.a. 
Minster, 2008
USA CL  6  (detail)  1009
(68%)
M72.8 + 6.2
(-)
-1009
(60%)
74.1 + 6.2
(-)
Negative
Reiman, 2007
USA, Netherlands CL  14  (detail)  861
(-)
M-74.9 + 6.6
(-)
550
(-)
77.4 + 7.3
(-)
Negative
Reynolds, 2009
Sweden CL  6  (detail)  896
(-)
M--248
(-)
-Negative
Rogaeva, 2007
Mixed (Northern European) CL  29  (detail)  178
(-)
C76 + 7
(-)
-242
(-)
73 + 8
(-)
Positive
Rogaeva, 2007
USA (Mayo - AUT) CL  10  (detail)  423
(-)
N76 + 6
(-)
-430
(-)
74 + 6
(-)
Positive
Rogaeva, 2007
USA (MCJ) CL  10  (detail)  549
(-)
M77 + 5
(-)
-477
(-)
75 + 6
(-)
Positive
Rogaeva, 2007
USA (MCR) CL  10  (detail)  433
(-)
M76 + 6
(-)
-1217
(-)
77 + 5
(-)
Positive
Webster, 2007
Re-analysis of Reiman, 2007 CL  0  -M----n.a.
Webster, 2010
Overlaps with
Reiman, 2007
CL  6  (detail)  861
(-)
M-82.8 + 7.7
(-)
550
(-)
79.7 + 6.3
(-)
Negative 
 African Descent
Lee, 2007
USA CO  29  (detail)  88
(78%)
C83.3 + 7.3
(-)
-158
(73%)
81.1 + 6.1
(-)
Positive
 Asian
Kimura, 2009
Japan CL  8  (detail)  437
(70%)
C72 + 8.2
(-)
-451
(62%)
74.7 + 5.9
(-)
Positive
Shibata, 2008
Japan CL  7  (detail)  180
(56%)
C-67.4 + 6.2
(-)
130
(52%)
64.4 + 6.7
(-)
Negative
Tan, 2007
China CL  7  (detail)  223
(55%)
C71.2 + 8.9
(38-89)
74.9 + 8.9
(44-93)
263
(52%)
71 + 8.5
(40-91)
Positive
 Hispanic
Lee, 2007
USA CO  29  (detail)  178
(73%)
C80.9 + 6.8
(-)
-194
(74%)
79.1 + 5.1
(-)
Positive
 Other/Mixed
Rogaeva, 2007
Israel (Wadi Ara) PO  29  (detail)  111
(-)
C83 + 8
(-)
-114
(-)
76 + 6
(-)
Positive
Contact us if you are an author of an association study regarding this gene and do not find your study in this table or find errors in the representation of your study details.
2. Family-Based Studies (by ethnic group)
      Affecteds Unaffecteds    
Study Population # Polys # Families # Subjects
(% women)
DX Onset Age
(range)
Age
(range)
# Subjects
(% women)
Age
(range)
Result Comment
 Caucasian
Cuenco, 2008
Overlaps with
Rogaeva, 2007
 30  (detail)  182189
(54%)
C67.2 + 9.1
(-)
-225
(61%)
70.1 + 9
(-)
n.a.
Reynolds, 2009
Sweden  6  (detail)   379
(-)
C--1955
(-)
-Negative
Rogaeva, 2007
Mixed (Northern European)  29  (detail)  124321
(-)
M70 + 9
(-)
-342
(-)
-Positive
Rogaeva, 2007
USA (Mirage)  29  (detail)  276279
(-)
C74 + 8
(-)
-252
(-)
-Negative
 African Descent
Cuenco, 2008
Overlaps with
Rogaeva, 2007
 30  (detail)  4244
(66%)
C70.6 + 9
(-)
-57
(68%)
71.3 + 9.5
(-)
n.a.
Rogaeva, 2007
USA (Mirage)  29  (detail)  238244
(-)
C74 + 8
(-)
-127
(-)
-Negative
 Hispanic
Rogaeva, 2007
USA, Caribbean  29  (detail)  228605
(-)
M73 + 11
(-)
-517
(-)
-Positive
 Other/Mixed
Schjeide, 2009
USA (CAG)  1  (detail)  217222
(59%)
M69.2 + 9
(50-89)
-267
(63%)
72.9 + 8.8
(49-92)
Negative
Schjeide, 2009
USA (NCRAD)  1  (detail)  340741
(74%)
M71.3 + 7.6
(50-98)
-300
(55%)
71 + 8.4
(39-93)
Negative
Schjeide, 2009
USA (NIA)  1  (detail)  351803
(64%)
M74.1 + 7.1
(52-98)
-290
(59%)
73.3 + 9.5
(36-94)
Negative
Schjeide, 2009
USA (NIMH)  1  (detail)  436995
(74%)
M72.4 + 7.7
(50-97)
-411
(58%)
70 + 10.7
(31-93)
Negative
Contact us if you are an author of an association study regarding this gene and do not find your study in this table or find errors in the representation of your study details.
Source:  Source of case population -> “CL” (clinic-based), “PO” (population-based), or “CO” (community-based).
# Polys:  Number of polymorphisms tested per gene and per sample.
Onset Age and Age:  Mean or median age at onset or examination, respectively.
DX:  Criteria used to determine AD diagnosis ->  "C" (clinical AD diagnosis), "N" (neuropathological AD diagnosis), "M" (mixed, i.e. AD sample contains both clinical and neuropathological cases), "U" (unknown).
Result:  Overall conclusion reached by authors of the original publication (“positive” usually indicates significant (P<0.05) association in at least one of the performed analyses, and “negative” indicates no evidence for significant association, while “trend” indicates results in between); results obtained in duplicate or largely overlapping samples are listed as "n.a.".
(-) :  Either no data provided or in case of overlap, data included in original study.
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Studies: 1395
Genes: 695
Polymorphisms: 2973
Meta-analyses: 320
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