AlzGene - Gene overview of all published AD-association studies for BACE1
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 Gene: BACE1  (BACE; ASP2; HSPC104; KIAA1149)  Entrez Gene
 Protein: beta-site APP-cleaving enzyme 1  (beta-secretase; APP beta-secretase; memapsin-2; aspartyl protease 2; transmembrane aspartic proteinase Asp2; membrane-associated aspartic protease 2; beta-site amyloid precursor protein cleaving enzyme)  ProteinLink
 Chromosome: 11   (View: 1  2  3  4  5  6  7  8  9  10  11  12  13  14  15  16  17  18  19  20  21  22  X  Y  MT)
 Status: Updated 18 April 2011
Meta-Analysis
1. Case-Control Studies (by ethnic group)
      AD Cases Normal Controls    
Study Population Source # Polys # Subjects
(% women)
DX Onset Age
(range)
Age
(range)
# Subjects
(% women)
Age
(range)
Result Comment
 Caucasian
Bettens, 2009
Belgium CL  7  (detail)  358
(64%)
M70.9 + 8.8
(-)
-462
(55%)
54.8 + 15.5
(-)
Negative
Clarimon, 2003
Spain CL  3  (detail)  136
(74%)
C-76.6 + 5.3
(-)
87
(52%)
74.9 + 5.3
(-)
Positive
Cousin, 2009
France CL  1  (detail)  428
(-)
C64.9 + 9.9
(-)
-475
(-)
66.2 + 10.8
(-)
Negative
Cruts, 2001
Netherlands PO  1  (detail)  101
(-)
C57 + 5
(-)
-185
(-)
-Negative
Emahazion, 2001
Scotland CL  1  (detail)  121
(-)
C--152
(-)
-Negative
Giedraitis, 2009
Sweden (ULSAM) CL  3  (detail)  86
(0%)
C80.2
(72-85)
-404
(0%)
81.8
(80-84)
Negative
Gold, 2003
Switzerland CO  2  (detail)  96
(55%)
C-79.9 + 9.3
(-)
170
(52%)
74.7 + 7.4
(-)
Trend
Kirschling, 2003
Germany CL  3  (detail)  184
(72%)
C-73 + 8.1
(52-92)
245
(53%)
71.8 + 9.2
(38-100)
Positive
Laws, 2009
Germany CL  11  (detail)  438
(59%)
C69 + 9.1
(-)
-290
(-)
66.8 + 12
(-)
Negative
Li, 2008
Canada CL  1  (detail)  753
(58%)
C71.9 + 8.5
(-)
77.8 + 8.6
(-)
736
(64%)
73.4 + 7.9
(-)
Negative
Murphy, 2001
UK CL  2  (detail)  239
(64%)
N-81.2 + 7.8
(-)
342
(59%)
82.1 + 3.8
(-)
Negative
Nicalaou, 2001
USA CL  1  (detail)  173
(-)
M76.1 + 7.8
(-)
-155
(-)
69.6 + 12.5
(-)
Negative
Nowotny, 2001
USA CL  1  (detail)  262
(49%)
C70 + 9.1
(-)
-274
(59%)
74.5 + 9
(-)
Positive
Randall, 2009
USA CL  2  (detail)  181
(71%)
C--119
(52%)
-Positive
Reiman, 2007
USA, Netherlands CL  1  (detail)  861
(-)
M-74.9 + 6.6
(-)
550
(-)
77.4 + 7.3
(-)
Negative
Todd, 2008
Ireland CL  10  (detail)  482
(61%)
C-77.9 + 7.3
(-)
419
(64%)
75.3 + 9
(-)
Negative
 Asian
Cai, 2005
China    1  (detail)  116
(62%)
U-74.5
(39-91)
271
(56%)
57.8
(33-95)
Positive
Jo, 2008
Korea CL  1  (detail)  248
(74%)
C-71.6 + 8.7
(-)
224
(61%)
68.3 + 6.3
(-)
Negative
Kan, 2005
China CL  1  (detail)  105
(46%)
C-79.2 + 6.3
(64-97)
130
(30%)
68.1 + 2.8
(65-77)
Positive
Liu, 2003
Taiwan CL  1  (detail)  98
(55%)
C-78.3 + 7.8
(-)
138
(50%)
76.2 + 4.6
(-)
Negative
Shi, 2004
China CL,CO  1  (detail)  369
(61%)
C74.8 + 8.2
(-)
78.2 + 8.5
(58-98)
355
(54%)
77.5 + 8
(59-99)
Positive
Wang, 2009
China CL  3  (detail)  429
(61%)
C71.3 + 7.2
(55-94)
-346
(83%)
72.5 + 8.1
(56-96)
Positive
Contact us if you are an author of an association study regarding this gene and do not find your study in this table or find errors in the representation of your study details.
Source:  Source of case population -> “CL” (clinic-based), “PO” (population-based), or “CO” (community-based).
# Polys:  Number of polymorphisms tested per gene and per sample.
Onset Age and Age:  Mean or median age at onset or examination, respectively.
DX:  Criteria used to determine AD diagnosis ->  "C" (clinical AD diagnosis), "N" (neuropathological AD diagnosis), "M" (mixed, i.e. AD sample contains both clinical and neuropathological cases), "U" (unknown).
Result:  Overall conclusion reached by authors of the original publication (“positive” usually indicates significant (P<0.05) association in at least one of the performed analyses, and “negative” indicates no evidence for significant association, while “trend” indicates results in between); results obtained in duplicate or largely overlapping samples are listed as "n.a.".
(-) :  Either no data provided or in case of overlap, data included in original study.
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Genes: 695
Polymorphisms: 2973
Meta-analyses: 320
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