AlzGene - Gene overview of all published AD-association studies for CALHM1
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 Gene: CALHM1  (FAM26C)  Entrez Gene
 Protein: calcium homeostasis modulator 1  (family with sequence similarity 26, member C)  ProteinLink
 Chromosome: 10   (View: 1  2  3  4  5  6  7  8  9  10  11  12  13  14  15  16  17  18  19  20  21  22  X  Y  MT)
 Status: Updated 3 November 2010
Meta-Analysis
1. Case-Control Studies (by ethnic group)
      AD Cases Normal Controls    
Study Population Source # Polys # Subjects
(% women)
DX Onset Age
(range)
Age
(range)
# Subjects
(% women)
Age
(range)
Result Comment
 Caucasian
Beecham, 2009
USA CL  1  (detail)  510
(-)
M73
(-)
-524
(-)
-Negative
Bertram, 2008
Sweden CL  1  (detail)  297
(61%)
C72.8 + 5.8
(48-92)
-256
(65%)
77.1 + 7.4
(60-98)
Negative
Bertram, 2008
Finland CL  1  (detail)  310
(68%)
C72 + 7
(43-87)
-435
(60%)
70 + 5
(37-89)
Negative
Boada, 2010b
Spain CL  2  (detail)  1140
(70%)
C77.5 + 7.7
(-)
78.8 + 7.9
(-)
1330
(52%)
52.4
(-)
Positive
Corneveaux, 2010
USA, UK & Netherlands (TGEN) CL  1  (detail)  1019
(64%)
N--591
(48%)
-Negative
Dreses-Werringloer, 2008
France (I) CL  1  (detail)  710
(61%)
C68.7 + 8.1
(-)
72.1 + 7.7
(-)
565
(61%)
72.1 + 8
(-)
Positive
Dreses-Werringloer, 2008
France (II) CL  1  (detail)  645
(61%)
C64.6 + 9.6
(-)
69 + 9.7
(-)
483
(53%)
67.5 + 10.2
(-)
Positive
Dreses-Werringloer, 2008
UK CL  1  (detail)  492
(56%)
M-74.5 + 7.9
(-)
205
(62%)
71.8 + 10.5
(-)
Positive
Dreses-Werringloer, 2008
Italy CL  1  (detail)  150
(64%)
C73.8 + 8.7
(-)
76.8 + 7.9
(-)
85
(62%)
70.8 + 9
(-)
Positive
Dreses-Werringloer, 2008
USA CL  1  (detail)  46
(-)
N--23
(-)
-Positive
Minster, 2009
USA CL  1  (detail)  945
(67%)
M72.8 + 6.2
(-)
-875
(59%)
73.8 + 6.3
(-)
Negative
Nacmias, 2010
Italy CL  1  (detail)  372
(62%)
C67 + 8.8
(-)
-386
(69%)
66.7 + 17
(-)
Negative
Sleegers, 2009
Belgium CL  1  (detail)  362
(74%)
C78.9 + 5.1
(-)
-519
(59%)
60.3 + 15.3
(-)
Negative
 Asian
Cui, 2009
China CL  1  (detail)  198
(60%)
M-73.9 + 7.2
(-)
189
(61%)
71.3 + 6.1
(-)
Positive
Inoue, 2009
Japan CL  3  (detail)  1154
(65%)
C70.2 + 8.9
(42-88)
73.2 + 8.7
(45-92)
1360
(58%)
73.6 + 6
(65-96)
Negative
Shibata, 2010
Japan CL  3  (detail)  180
(56%)
C-67.4 + 6.2
(-)
130
(52%)
64.4 + 6.7
(-)
Negative
Tan, 2009
Singapore CL  1  (detail)  241
(-)
C71 + 9
(38-89)
75 + 9
(44-93)
243
(-)
71 + 8
(44-91)
Negative
Contact us if you are an author of an association study regarding this gene and do not find your study in this table or find errors in the representation of your study details.
2. Family-Based Studies (by ethnic group)
      Affecteds Unaffecteds    
Study Population # Polys # Families # Subjects
(% women)
DX Onset Age
(range)
Age
(range)
# Subjects
(% women)
Age
(range)
Result Comment
 Caucasian
Bertram, 2008
USA (NIMH)  1  (detail)  410941
(74%)
M72.3 + 7.7
(50-97)
-404
(58%)
70 + 10.7
(31-93)
Negative
Bertram, 2008
USA (NIA)  1  (detail)  329748
(64%)
M74.2 + 7.1
(52-98)
-282
(58%)
73.4 + 9.6
(36-94)
Negative
Bertram, 2008
USA (NCRAD)  1  (detail)  331799
(66%)
M71.3 + 7.6
(50-98)
-293
(55%)
70.6 + 8.1
(39-93)
Negative
Bertram, 2008
USA (CAG)  1  (detail)  215220
(58%)
M69.3 + 9
(50-89)
-263
(63%)
73.3 + 8.6
(50-92)
Negative
Contact us if you are an author of an association study regarding this gene and do not find your study in this table or find errors in the representation of your study details.
Source:  Source of case population -> “CL” (clinic-based), “PO” (population-based), or “CO” (community-based).
# Polys:  Number of polymorphisms tested per gene and per sample.
Onset Age and Age:  Mean or median age at onset or examination, respectively.
DX:  Criteria used to determine AD diagnosis ->  "C" (clinical AD diagnosis), "N" (neuropathological AD diagnosis), "M" (mixed, i.e. AD sample contains both clinical and neuropathological cases), "U" (unknown).
Result:  Overall conclusion reached by authors of the original publication (“positive” usually indicates significant (P<0.05) association in at least one of the performed analyses, and “negative” indicates no evidence for significant association, while “trend” indicates results in between); results obtained in duplicate or largely overlapping samples are listed as "n.a.".
(-) :  Either no data provided or in case of overlap, data included in original study.
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Studies: 1395
Genes: 695
Polymorphisms: 2973
Meta-analyses: 320
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