AlzGene - Gene overview of all published AD-association studies for PON1
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 Gene: PON1  (ESA; PON)  Entrez Gene    View on ALSGene   View on MSGene   View on PDGene   View on SZGene
 Protein: paraoxonase 1   ProteinLink
 Chromosome: 7   (View: 1  2  3  4  5  6  7  8  9  10  11  12  13  14  15  16  17  18  19  20  21  22  X  Y  MT)
 Status: Updated 18 April 2011
Meta-Analysis
1. Case-Control Studies (by ethnic group)
      AD Cases Normal Controls    
Study Population Source # Polys # Subjects
(% women)
DX Onset Age
(range)
Age
(range)
# Subjects
(% women)
Age
(range)
Result Comment
 Caucasian
Cellini, 2006
Italy CL  1  (detail)  306
(61%)
C66.3 + 8.7
(-)
-275
(69%)
76.1 + 14.2
(-)
Negative
Chapuis, 2007
France CL  5  (detail)  629
(63%)
C69.6 + 8.7
(-)
73 + 8.8
(-)
669
(64%)
73.1 + 8.5
(-)
Positive
Dantoine, 2002
France    2  (detail)  45
(76%)
C-80 + 7.2
(-)
64
(59%)
79.5 + 6.3
(-)
Negative
Helbecque, 2004
France CL  2  (detail)  70
(-)
C--253
(68%)
79 + 8
(-)
Negative
Leduc, 2008
Overlaps with
Leduc, 2009
CL  2  (detail)  136
(-)
N--91
(-)
-n.a.
Leduc, 2009
Canada CL  2  (detail)  636
(58%)
M72.5 + 8.5
(-)
77.5 + 9.2
(-)
434
(51%)
74.5 + 11.5
(-)
Positive
Li, 2008
Canada CL  1  (detail)  753
(58%)
C71.9 + 8.5
(-)
77.8 + 8.6
(-)
736
(64%)
73.4 + 7.9
(-)
Trend
Pola, 2003
Italy CL  1  (detail)  124
(61%)
C-77.3 + 5.7
(-)
135
(56%)
76.5 + 7.2
(-)
Negative
Scacchi, 2003
Italy CL  1  (detail)  236
(68%)
C-79.4 + 7.4
(61-95)
226
(55%)
79.2 + 8.5
(61-99)
Positive
Zuiliani, 2001
Italy CL  1  (detail)  40
(70%)
C-79.2 + 1
(-)
54
(67%)
82.1 + 0.8
(-)
Negative
 Asian
He, 2006
China CL  1  (detail)  521
(61%)
C70.7 + 9.2
(-)
75.6 + 9.8
(46-99)
578
(57%)
69.9 + 8.3
(53-93)
Positive
Sodeyama, 1999
Overlaps with
Yamada, 2002
CL  1  (detail)  ------n.a.
Yamada, 2001
Overlaps with
Yamada, 2002
   1  (detail)  ------n.a.
Yamada, 2002
Japan CL  1  (detail)  82
(-)
N-86.1 + 7.9
(62-104)
119
(-)
85.7 + 8
(65-103)
Negative
Contact us if you are an author of an association study regarding this gene and do not find your study in this table or find errors in the representation of your study details.
2. Family-Based Studies (by ethnic group)
      Affecteds Unaffecteds    
Study Population # Polys # Families # Subjects
(% women)
DX Onset Age
(range)
Age
(range)
# Subjects
(% women)
Age
(range)
Result Comment
 Caucasian
Erlich, 2005
Mixed  11  (detail)  265277
(67%)
M-74
(-)
329
(60%)
70.3
(-)
Positive
 African Descent
Erlich, 2005
Mixed  11  (detail)  237243
(77%)
M-76.7
(-)
143
(67%)
72.9
(-)
Positive
Contact us if you are an author of an association study regarding this gene and do not find your study in this table or find errors in the representation of your study details.
Source:  Source of case population -> “CL” (clinic-based), “PO” (population-based), or “CO” (community-based).
# Polys:  Number of polymorphisms tested per gene and per sample.
Onset Age and Age:  Mean or median age at onset or examination, respectively.
DX:  Criteria used to determine AD diagnosis ->  "C" (clinical AD diagnosis), "N" (neuropathological AD diagnosis), "M" (mixed, i.e. AD sample contains both clinical and neuropathological cases), "U" (unknown).
Result:  Overall conclusion reached by authors of the original publication (“positive” usually indicates significant (P<0.05) association in at least one of the performed analyses, and “negative” indicates no evidence for significant association, while “trend” indicates results in between); results obtained in duplicate or largely overlapping samples are listed as "n.a.".
(-) :  Either no data provided or in case of overlap, data included in original study.
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Studies: 1395
Genes: 695
Polymorphisms: 2973
Meta-analyses: 320
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