AlzGene - Gene overview of all published AD-association studies for VR22
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 Gene: VR22  (CTNNA3; MGC26194)  Entrez Gene
 Protein: catenin (cadherin-associated protein), alpha 3  (alpha-catenin-like protein)  ProteinLink
 Chromosome: 10   (View: 1  2  3  4  5  6  7  8  9  10  11  12  13  14  15  16  17  18  19  20  21  22  X  Y  MT)
 Status: Updated 18 April 2011
Meta-Analysis
1. Case-Control Studies (by ethnic group)
      AD Cases Normal Controls    
Study Population Source # Polys # Subjects
(% women)
DX Onset Age
(range)
Age
(range)
# Subjects
(% women)
Age
(range)
Result Comment
 Caucasian
Blomqvist, 2004
Sweden CL  1  (detail)  527
(60%)
M73.2 + 8
(-)
78.2 + 7.1
(-)
511
(63%)
79.9 + 5.2
(-)
Negative
Blomqvist, 2004
Scotland CL  1  (detail)  121
(42%)
C52.4 + 6.8
(-)
57.8 + 6.3
(-)
152
(46%)
58.2 + 9.8
(-)
Negative
Busby, 2004
UK (I) CL  2  (detail)  145
(76%)
C-77 + 4.5
(-)
121
(76%)
76 + 6.9
(-)
Negative
Busby, 2004
USA (I) CL  2  (detail)  266
(67%)
C-74 + 10.1
(-)
448
(62%)
83 + 7.5
(-)
Negative
Busby, 2004
USA (II) CL  2  (detail)  422
(50%)
C-77 + 6.9
(-)
381
(49%)
83 + 8.4
(-)
Negative
Busby, 2004
UK (II) CL  2  (detail)  108
(81%)
C-74 + 6.2
(-)
106
(62%)
76 + 6.5
(-)
Negative
Cellini, 2005
Italy CL  2  (detail)  302
(-)
C68 + 5.1
(-)
-164
(-)
-Positive
Edwards, 2009
Overlaps with
Martin, 2005
CL  8  (detail)  296
(-)
M71.7 + 7.8
(-)
79 + 6.6
(-)
566
(-)
73.6 + 6.3
(-)
n.a.
Grupe, 2006
Overlaps with
Busby, 2004
CL  0  422
(-)
C--382
(-)
-n.a.
Li, 2008
Canada CL  1  (detail)  753
(58%)
C71.9 + 8.5
(-)
77.8 + 8.6
(-)
736
(64%)
73.4 + 7.9
(-)
Negative
Liang, 2007
Overlaps with
Martin, 2005
CL  7  (detail)  483
(63%)
C71.8 + 6
(-)
76.5 + 6.5
(-)
879
(58%)
72 + 6.3
(-)
n.a.
Martin, 2005
USA CL  8  (detail)  584
(-)
M71.1 + 6.7
(-)
-858
(-)
71.9 + 6.3
(-)
Positive
Morgan, 2008
UK (MRC) CL  1  (detail)  1160
(70%)
C75.6 + 6.8
(59-95)
-1389
(62%)
76.3 + 6.2
(-)
Positive
Reiman, 2007
USA, Netherlands CL  1  (detail)  861
(-)
M-74.9 + 6.6
(-)
550
(-)
77.4 + 7.3
(-)
Negative
 Asian
Kuwano, 2006
Japan CL  1  (detail)  1526
(72%)
C73.4 + 6.6
(-)
-1666
(60%)
73 + 7.8
(-)
Negative
Miyashita, 2007
Overlaps with
Kuwano, 2006
CL  7  (detail)  1526
(72%)
C73.4 + 6.6
(-)
-1666
(60%)
73 + 7.8
(-)
Positive
Contact us if you are an author of an association study regarding this gene and do not find your study in this table or find errors in the representation of your study details.
2. Family-Based Studies (by ethnic group)
      Affecteds Unaffecteds    
Study Population # Polys # Families # Subjects
(% women)
DX Onset Age
(range)
Age
(range)
# Subjects
(% women)
Age
(range)
Result Comment
 Caucasian
Bertram, 2007
USA (NIMH)  5  (detail)  437994
(-)
M72.4 + 7.7
(50-97)
-411
(-)
-Positive
Bertram, 2007
USA (CAG)  1  (detail)  217224
(-)
M71.2 + 9.1
(50-89)
-265
(-)
-Negative
Ertekin-Taner, 2003
USA (I)  3  (detail)  10-M----Positive
Ertekin-Taner, 2003
USA (II)  3  (detail)  12-M----Positive
Liang, 2007
Overlaps with
Martin, 2005
 7  (detail)  5671521
(67%)
C72.9 + 6.4
(-)
80.1 + 7.1
(-)
974
(56%)
69.9 + 11.2
(-)
n.a.
Martin, 2005
USA  8  (detail)  738-M72.3 + 9.1
(-)
--74.8 + 11.8
(-)
Positive
Contact us if you are an author of an association study regarding this gene and do not find your study in this table or find errors in the representation of your study details.
Source:  Source of case population -> “CL” (clinic-based), “PO” (population-based), or “CO” (community-based).
# Polys:  Number of polymorphisms tested per gene and per sample.
Onset Age and Age:  Mean or median age at onset or examination, respectively.
DX:  Criteria used to determine AD diagnosis ->  "C" (clinical AD diagnosis), "N" (neuropathological AD diagnosis), "M" (mixed, i.e. AD sample contains both clinical and neuropathological cases), "U" (unknown).
Result:  Overall conclusion reached by authors of the original publication (“positive” usually indicates significant (P<0.05) association in at least one of the performed analyses, and “negative” indicates no evidence for significant association, while “trend” indicates results in between); results obtained in duplicate or largely overlapping samples are listed as "n.a.".
(-) :  Either no data provided or in case of overlap, data included in original study.
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Studies: 1395
Genes: 695
Polymorphisms: 2973
Meta-analyses: 320
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