AlzGene - Gene overview of all published AD-association studies for TF
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 Gene: TF   Entrez Gene    View on PDGene   View on SZGene
 Protein: transferrin  (PRO1557; PRO2086)  ProteinLink
 Chromosome: 3   (View: 1  2  3  4  5  6  7  8  9  10  11  12  13  14  15  16  17  18  19  20  21  22  X  Y  MT)
 Status: Updated 18 April 2011
Meta-Analysis
1. Case-Control Studies (by ethnic group)
      AD Cases Normal Controls    
Study Population Source # Polys # Subjects
(% women)		 DX Onset Age
(range)		 Age
(range)		 # Subjects
(% women)		 Age
(range)		 Result Comment
 Caucasian
Blazquez, 2006
 Spain CL  1  (detail)  211
(58%)		C72.2 + 8.3
(-)		73.5 + 7.7
(-)		167
(58%)		72.1 + 6.8
(-)		Negative
Corder, 2006
 Overlaps with
Robson, 2004		 CL  1  (detail)  315
(-)		M--260
(-)		-n.a.
Emahazion, 2001
 Scotland CL  1  (detail)  121
(-)		C--152
(-)		-Negative
Giedraitis, 2009
 Sweden (ULSAM) CL  1  (detail)  86
(0%)		C80.2
(72-85)		-404
(0%)		81.8
(80-84)		Negative
Hussain, 2002
 UK CL  1  (detail)  180
(-)		M-77.9 + 8
(46-93)		121
(-)		77.9 + 8.7
(65-100)		Negative
Kauwe, 2009
 USA (WashU) CL  1  (detail)  331
(62%)		C-76.6
(-)		385
(61%)		77.7
(-)		Positive
Kauwe, 2009
 UK (MRC) CL  1  (detail)  631
(73%)		C-75.7
(-)		769
(62%)		76.1
(-)		Negative
Kauwe, 2009
 USA (ADNI) CL  1  (detail)  199
(56%)		C-71.8
(-)		188
(55%)		77.7
(-)		Negative
Lehmann, 2006
 Overlaps with
Robson, 2004		 CL  1  (detail)  -U----n.a.
Li, 2008
 Canada CL  1  (detail)  753
(58%)		C71.9 + 8.5
(-)		77.8 + 8.6
(-)		736
(64%)		73.4 + 7.9
(-)		Negative
Lleo, 2002
 Spain CL,CO  1  (detail)  108
(74%)		C-78.8
(61-93)		110
(62%)		73.6
(45-92)		Negative
Reiman, 2007
 USA, Netherlands CL  1  (detail)  861
(-)		M-74.9 + 6.6
(-)		550
(-)		77.4 + 7.3
(-)		Negative
Robson, 2004
 UK CL  1  (detail)  191
(57%)		M70.5 + 9.2
(-)		-269
(-)		76.1 + 8.9
(-)		Trend
Rondeau, 2006
 France CO  1  (detail)  55
(-)		C--237
(-)		-Negative
Van Landeghem, 1998
 Sweden CL  1  (detail)  64
(-)		U--2133
(-)		-Positive
Webster, 2010
 Overlaps with
Reiman, 2007		 CL  1  (detail)  861
(-)		M-82.8 + 7.7
(-)		550
(-)		79.7 + 6.3
(-)		n.a. 
Zambenedetti, 2003
 Italy CL  1  (detail)  132
(67%)		C-68 + 0.6
(-)		318
(64%)		70 + 0
(-)		Trend
 Asian
Kim, 2001a
 Korea CL  1  (detail)  164
(72%)		C-70.5 + 8
(-)		239
(78%)		68.3 + 4.6
(-)		Negative
Kim, 2001b
 Overlaps with
Kim, 2001a		 CL  1  (detail)  164
(-)		C-71.7 + 8.7
(-)		239
(-)		69 + 5
(-)		n.a.
Namekata, 1997
 Japan CL  1  (detail)  294
(-)		C69 + 5.9
(38-93)		-291
(-)		70.9 + 7.3
(60-93)		Positive
Zhang, 2003
 China CL  1  (detail)  67
(60%)		C-80 + 6.6
(-)		131
(31%)		69 + 9.4
(-)		Trend
 Other/Mixed
Van Rensburg, 1993
 South Africa    1  (detail)  20
(-)		U--158
(-)		-Positive
Van Rensburg, 2000
 South Africa    1  (detail)  27
(-)		C--27
(-)		-Trend
Contact us if you are an author of an association study regarding this gene and do not find your study in this table or find errors in the representation of your study details.
2. Family-Based Studies (by ethnic group)
      Affecteds Unaffecteds    
Study Population # Polys # Families # Subjects
(% women)		 DX Onset Age
(range)		 Age
(range)		 # Subjects
(% women)		 Age
(range)		 Result Comment
 Other/Mixed
Schjeide, 2009
 USA (CAG)  1  (detail)  217222
(59%)		M69.2 + 9
(50-89)		-267
(63%)		72.9 + 8.8
(49-92)		Positive
Schjeide, 2009
 USA (NCRAD)  1  (detail)  340741
(74%)		M71.3 + 7.6
(50-98)		-300
(55%)		71 + 8.4
(39-93)		Negative
Schjeide, 2009
 USA (NIA)  1  (detail)  351803
(64%)		M74.1 + 7.1
(52-98)		-290
(59%)		73.3 + 9.5
(36-94)		Negative
Schjeide, 2009
 USA (NIMH)  1  (detail)  436995
(74%)		M72.4 + 7.7
(50-97)		-411
(58%)		70 + 10.7
(31-93)		Negative
Contact us if you are an author of an association study regarding this gene and do not find your study in this table or find errors in the representation of your study details.
Source:  Source of case population -> “CL” (clinic-based), “PO” (population-based), or “CO” (community-based).
# Polys:  Number of polymorphisms tested per gene and per sample.
Onset Age and Age:  Mean or median age at onset or examination, respectively.
DX:  Criteria used to determine AD diagnosis ->  "C" (clinical AD diagnosis), "N" (neuropathological AD diagnosis), "M" (mixed, i.e. AD sample contains both clinical and neuropathological cases), "U" (unknown).
Result:  Overall conclusion reached by authors of the original publication (“positive” usually indicates significant (P<0.05) association in at least one of the performed analyses, and “negative” indicates no evidence for significant association, while “trend” indicates results in between); results obtained in duplicate or largely overlapping samples are listed as "n.a.".
(-) :  Either no data provided or in case of overlap, data included in original study.
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AlzGene Stats
Studies: 1395
Genes: 695
Polymorphisms: 2973
Meta-analyses: 320
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The National Cell Repository for Alzheimer Disease seeks to recruit 1,000 families with two or more living brothers or sisters who have been diagnosed with late onset Alzheimer’s disease.
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