AlzGene - Gene overview of all published AD-association studies for TNF
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 Gene: TNF  (TNFA; DIF; TNFSF2)  Entrez Gene    View on ALSGene   View on MSGene   View on PDGene   View on SZGene
 Protein: tumor necrosis factor alpha  (cachectin; APC1 protein; TNF, monocyte-derived; TNF, macrophage-derived; TNF superfamily, member 2)  ProteinLink
 Chromosome: 6   (View: 1  2  3  4  5  6  7  8  9  10  11  12  13  14  15  16  17  18  19  20  21  22  X  Y  MT)
 Status: Updated 29 January 2010
Meta-Analysis
1. Case-Control Studies (by ethnic group)
      AD Cases Normal Controls    
Study Population Source # Polys # Subjects
(% women)
DX Onset Age
(range)
Age
(range)
# Subjects
(% women)
Age
(range)
Result Comment
 Caucasian
Alvarez, 2002
Spain CL  2  (detail)  315
(66%)
C-74.1 + 7.9
(60-97)
400
(56%)
74 + 8.9
(60-95)
Positive
Combarros, 2004
Same as Infante, 2002    1  (detail)  -C----n.a.
Emahazion, 2001
Scotland CL  1  (detail)  121
(-)
C--152
(-)
-Negative
Gnjec, 2008
Australia CL  2  (detail)  272
(59%)
C-77.1 + 10.5
(-)
359
(46%)
76.7 + 13.1
(-)
Positive
Infante, 2002
Spain CL  1  (detail)  321
(67%)
C71.9 + 8.9
(40-95)
75.6 + 9
(50-98)
312
(70%)
80.2 + 7.8
(63-100)
Negative
Laws, 2005
Germany CL  2  (detail)  506
(62%)
C68.7 + 9.9
(-)
71.5 + 10
(-)
277
(61%)
65.3 + 12.5
(-)
Positive
Lehmann, 2001
UK (OPTIMA) CL  2  (detail)  55
(64%)
N-81.7
(-)
73
(59%)
79.3
(-)
Negative
Licastro, 2006
Overlaps with
Lio, 2006
CL  1  (detail)  260
(-)
C--190
(-)
-n.a.
Lio, 2006
Italy CL  1  (detail)  222
(68%)
C--240
(55%)
-Positive
McCusker, 2001
Ireland CL  1  (detail)  242
(62%)
C-75.4 + 8.1
(-)
235
(69%)
74.7 + 8.1
(-)
Trend
Ramos, 2006
USA CL  2  (detail)  265
(62%)
M--347
(63%)
-Positive
Randall, 2009
USA CL  5  (detail)  181
(71%)
C--119
(52%)
-Positive
Tarkowski, 2000
Sweden CL  1  (detail)  52
(56%)
C-74.1 + 1
(51-90)
25
(68%)
68 + 2
(49-83)
Negative
Tedde, 2008
Italy CL  5  (detail)  253
(59%)
C66.8 + 9.1
(-)
63.9 + 11.5
(39-85)
356
(68%)
61.8 + 19.4
(36-95)
Negative
Terrini, 2003
Italy CL  1  (detail)  256
(70%)
C-76.4 + 7.5
(-)
200
(69%)
70.5 + 11.3
(-)
Negative
 African Descent
Perry, 2001
USA CL  2  (detail)  111
(69%)
M70.8 + 7.8
(-)
71.3 + 7.7
(-)
78
(76%)
75.2 + 7.6
(-)
Positive
 Asian
Fung, 2005
Taiwan CL  3  (detail)  125
(61%)
C-75.3 + 7.2
(-)
109
(45%)
51 + 14.7
(-)
Negative
Ma, 2004
China CL  3  (detail)  92
(75%)
C-77
(61-90)
110
(76%)
73
(61-85)
Positive
Nishimura, 2004
Japan CL  1  (detail)  172
(60%)
C-77.4 + 9.7
(55-96)
163
(61%)
75.5 + 9.9
(-)
Negative
Wang, 2008
China CL  1  (detail)  207
(52%)
C-77.6 + 6.4
(65-97)
222
(39%)
72.3 + 5.3
(65-77)
Positive
Yang, 2008
China CL  1  (detail)  112
(48%)
C67.5 + 3.4
(-)
73.2 + 2.5
(64-91)
121
(48%)
74.3 + 2.8
(63-88)
Positive
 Other/Mixed
Culpan, 2003
USA & Europe CL  3  (detail)  235
(64%)
N-80.7
(-)
130
(48%)
78.1
(-)
Positive
Vural, 2009
Turkey CL  1  (detail)  101
(65%)
C71.4
(-)
76.3 + 6.8
(65-99)
138
(67%)
73.1 + 6.9
(62-94)
Positive
Contact us if you are an author of an association study regarding this gene and do not find your study in this table or find errors in the representation of your study details.
2. Family-Based Studies (by ethnic group)
      Affecteds Unaffecteds    
Study Population # Polys # Families # Subjects
(% women)
DX Onset Age
(range)
Age
(range)
# Subjects
(% women)
Age
(range)
Result Comment
 Other/Mixed
Collins, 2000
USA (NIMH)  3  (detail)  145311
(69%)
M69.4
(-)
-251
(64%)
72.5
(-)
Positive
Contact us if you are an author of an association study regarding this gene and do not find your study in this table or find errors in the representation of your study details.
Source:  Source of case population -> “CL” (clinic-based), “PO” (population-based), or “CO” (community-based).
# Polys:  Number of polymorphisms tested per gene and per sample.
Onset Age and Age:  Mean or median age at onset or examination, respectively.
DX:  Criteria used to determine AD diagnosis ->  "C" (clinical AD diagnosis), "N" (neuropathological AD diagnosis), "M" (mixed, i.e. AD sample contains both clinical and neuropathological cases), "U" (unknown).
Result:  Overall conclusion reached by authors of the original publication (“positive” usually indicates significant (P<0.05) association in at least one of the performed analyses, and “negative” indicates no evidence for significant association, while “trend” indicates results in between); results obtained in duplicate or largely overlapping samples are listed as "n.a.".
(-) :  Either no data provided or in case of overlap, data included in original study.
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Studies: 1395
Genes: 695
Polymorphisms: 2973
Meta-analyses: 320
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