AlzGene - Gene overview of all published AD-association studies for HFE
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 Gene: HFE  (HH; HFE1; HLA-H)  Entrez Gene    View on ALSGene   View on MSGene   View on PDGene
 Protein: hemochromatosis  (hereditary haemochromatosis protein; hemochromatosis protein)  ProteinLink
 Chromosome: 6   (View: 1  2  3  4  5  6  7  8  9  10  11  12  13  14  15  16  17  18  19  20  21  22  X  Y  MT)
 Status: Updated 18 April 2011
Meta-Analysis
1. Case-Control Studies (by ethnic group)
      AD Cases Normal Controls    
Study Population Source # Polys # Subjects
(% women)
DX Onset Age
(range)
Age
(range)
# Subjects
(% women)
Age
(range)
Result Comment
 Caucasian
Alizadeh, 2007
Netherlands PO  2  (detail)  268
(73%)
C-78 + 0.5
(-)
2079
(-)
66 + 0.2
(-)
Trend
Berlin, 2004
Canada CL  2  (detail)  213
(53%)
C-76.5 + 6.8
(-)
63
(-)
75 + 5.5
(-)
Negative
Blazquez, 2006
Spain CL  2  (detail)  211
(58%)
C72.2 + 8.3
(-)
73.5 + 7.7
(-)
167
(58%)
72.1 + 6.8
(-)
Positive
Candore, 2003
Italy CL  3  (detail)  123
(64%)
C-69.4 + 10.6
(-)
152
(40%)
57.8 + 5.8
(-)
Negative
Corder, 2006
Overlaps with
Robson, 2004
CL  2  (detail)  315
(-)
M--260
(-)
-n.a.
Guerreiro, 2006
Portugal CL  2  (detail)  130
(61%)
C71.5 + 4.9
(-)
75 + 5
(-)
115
(67%)
70.7 + 10.3
(-)
Negative
Kauwe, 2009
USA (WashU) CL  1  (detail)  331
(62%)
C-76.6
(-)
385
(61%)
77.7
(-)
Positive
Kauwe, 2009
UK (MRC) CL  1  (detail)  631
(73%)
C-75.7
(-)
769
(62%)
76.1
(-)
Negative
Kauwe, 2009
USA (ADNI) CL  1  (detail)  199
(56%)
C-71.8
(-)
188
(55%)
77.7
(-)
Negative
Lehmann, 2006
Overlaps with
Robson, 2004
CL  2  (detail)  -U----n.a.
Li, 2008
Canada CL  1  (detail)  753
(58%)
C71.9 + 8.5
(-)
77.8 + 8.6
(-)
736
(64%)
73.4 + 7.9
(-)
Negative
Lleo, 2002
Spain CL,CO  2  (detail)  108
(74%)
C-78.8
(61-93)
110
(62%)
73.6
(45-92)
Negative
Moalem, 2000
Canada CL  2  (detail)  26
(54%)
C--41
(54%)
63 + 9.4
(-)
Trend
Percy, 2008
Canada CL  2  (detail)  54
(61%)
C-74 + 9.7
(-)
58
(59%)
72.5 + 9.6
(-)
Negative
Pulliam, 2003
USA CO  3  (detail)  133
(-)
N--67
(52%)
-Positive
Reiman, 2007
USA, Netherlands CL  1  (detail)  861
(-)
M-74.9 + 6.6
(-)
550
(-)
77.4 + 7.3
(-)
Negative
Robson, 2004
UK CO  2  (detail)  191
(57%)
M70.5 + 9.2
(-)
76.1 + 8.9
(-)
269
(52%)
76.1 + 8.9
(-)
Trend
Sampietro, 2001
Italy CL  2  (detail)  107
(67%)
C-80 + 6
(66-93)
99
(52%)
79 + 7
(62-92)
Positive
Contact us if you are an author of an association study regarding this gene and do not find your study in this table or find errors in the representation of your study details.
Source:  Source of case population -> “CL” (clinic-based), “PO” (population-based), or “CO” (community-based).
# Polys:  Number of polymorphisms tested per gene and per sample.
Onset Age and Age:  Mean or median age at onset or examination, respectively.
DX:  Criteria used to determine AD diagnosis ->  "C" (clinical AD diagnosis), "N" (neuropathological AD diagnosis), "M" (mixed, i.e. AD sample contains both clinical and neuropathological cases), "U" (unknown).
Result:  Overall conclusion reached by authors of the original publication (“positive” usually indicates significant (P<0.05) association in at least one of the performed analyses, and “negative” indicates no evidence for significant association, while “trend” indicates results in between); results obtained in duplicate or largely overlapping samples are listed as "n.a.".
(-) :  Either no data provided or in case of overlap, data included in original study.
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Studies: 1395
Genes: 695
Polymorphisms: 2973
Meta-analyses: 320
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