AlzGene - Meta-Analysis of All Published AD Association Studies (Case-Control Only) BDNF_270C/T
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 Polymorphism: BDNF_270C/T
 Gene: BDNF  (MGC34632)  Entrez Gene    View on MSGene   View on PDGene   View on SZGene
 Protein: brain-derived neurotrophic factor  (neurotrophin)  ProteinLink
 Chromosome: 11   (View: 1  2  3  4  5  6  7  8  9  10  11  12  13  14  15  16  17  18  19  20  21  22  X  Y  MT)
 Status: Updated 18 April 2011
Gene Overview
 Polymorphism:
1) Summary of Allele and Genotype Distribution of all Published Association Studies (by Ethnic Group)
      Alleles Genotypes
  # Case-Control
Samples
  T-Allele
(frequency)
C-Allele
(frequency)
T/T
(frequency)
T/C
(frequency)
C/C
(frequency)
 Caucasian 12 AD
CTR
0.07
0.11
0.93
0.90
18 (0.005)
6 (0.002)
424 (0.126)
609 (0.206)
2913 (0.868)
2347 (0.792)
 African Descent 1 AD
CTR
0.03
0.05
0.97
0.95
0 (0.000)
0 (0.000)
4 (0.069)
4 (0.095)
54 (0.931)
38 (0.905)
 Asian 5 AD
CTR
0.05
0.03
0.96
0.97
1 (0.001)
3 (0.002)
97 (0.088)
91 (0.059)
1001 (0.911)
1447 (0.939)
 Other/Mixed 1 AD
CTR
0.02
0.05
0.98
0.95
0 (0.000)
0 (0.000)
4 (0.038)
7 (0.096)
102 (0.962)
66 (0.904)
Total 19 AD
CTR
0.06
0.08
0.94
0.92
19 (0.004)
9 (0.002)
529 (0.115)
711 (0.154)
4070 (0.881)
3898 (0.844)

Meta-Analysis Methods      * New * Cumulative Meta-analysis
2) Forest plot for polymorphism BDNF_270C/T

Please also see disclaimer for more information on these meta-analyses.


Meta-analyses have not been performed on the following polymorphisms since they lack published genotype data in at least four independent case-control samples, or the published genotype data was otherwise not eligible for inclusion (see methods for details):

BDNF_270C/T
G-712A
rs1048218
rs1048220
rs1048221
rs11030121
rs2030324
rs2049045
rs2049046
rs2203877
rs7103411
rs7124442
rs8192466
SNP5

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Studies: 1395
Genes: 695
Polymorphisms: 2973
Meta-analyses: 320
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An up-to-date collection of all published genetic association studies.