AlzGene - Meta-Analysis of All Published AD Association Studies (Case-Control Only) rs1799983
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 Polymorphism: rs1799983 (E298D)
 Gene: NOS3   Entrez Gene    View on ALSGene   View on MSGene   View on PDGene   View on SZGene
 Protein: nitric oxide synthase 3 (endothelial cell)   ProteinLink
 Chromosome: 7   (View: 1  2  3  4  5  6  7  8  9  10  11  12  13  14  15  16  17  18  19  20  21  22  X  Y  MT)
 Status: Updated 18 April 2011
Gene Overview
 Polymorphism:
1) Summary of Allele and Genotype Distribution of all Published Association Studies (by Ethnic Group)
      Alleles Genotypes
  # Case-Control
Samples		   T-Allele
(frequency)		 G-Allele
(frequency)		 T/T
(frequency)		 T/G
(frequency)		 G/G
(frequency)
 Caucasian 10 AD
CTR		 0.32
0.33		 0.68
0.67		 229 (0.108)
192 (0.104)		 903 (0.426)
820 (0.445)		 989 (0.466)
831 (0.451)
 African Descent 1 AD
CTR		 0.09
0.17		 0.91
0.84		 0 (0.000)
1 (0.012)		 42 (0.179)
25 (0.305)		 193 (0.821)
56 (0.683)
 Asian 3 AD
CTR		 0.07
0.09		 0.93
0.91		 6 (0.007)
5 (0.006)		 120 (0.130)
149 (0.167)		 795 (0.863)
739 (0.828)
 Other/Mixed 3 AD
CTR		 0.30
0.34		 0.70
0.66		 75 (0.085)
56 (0.090)		 388 (0.439)
305 (0.493)		 421 (0.476)
258 (0.417)
Total 17 AD
CTR		 0.25
0.26		 0.75
0.74		 310 (0.075)
254 (0.074)		 1453 (0.349)
1299 (0.378)		 2398 (0.576)
1884 (0.548)

Meta-Analysis Methods      * New * Cumulative Meta-analysis
2) Forest plot for polymorphism  rs1799983 (E298D)

Please also see disclaimer for more information on these meta-analyses.

Meta-analyses have not been performed on the following polymorphisms since they lack published genotype data in at least four independent case-control samples, or the published genotype data was otherwise not eligible for inclusion (see methods for details):

NOS3_27bp-rep (intron 4)
rs1007311
rs1077872
rs1800779
rs1800780
rs1800781
rs1800783
rs2070744 (-786 T/C)
rs3918166
rs743506
rs743507

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8. CD33
9. MS4A4E
10. CD2AP
AlzGene Stats
Studies: 1395
Genes: 695
Polymorphisms: 2973
Meta-analyses: 320
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An up-to-date collection of all published genetic association studies.