AlzGene - Meta-Analysis of All Published AD Association Studies (Case-Control Only) rs4845378
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 Polymorphism: rs4845378
 Gene: CHRNB2   Entrez Gene    View on SZGene
 Protein: cholinergic receptor, nicotinic, beta polypeptide 2 (neuronal)   ProteinLink
 Chromosome: 1   (View: 1  2  3  4  5  6  7  8  9  10  11  12  13  14  15  16  17  18  19  20  21  22  X  Y  MT)
 Status: Updated 18 April 2011
Gene Overview
 Polymorphism:
1) Summary of Allele and Genotype Distribution of all Published Association Studies (by Ethnic Group)
      Alleles Genotypes
  # Case-Control
Samples		   T-Allele
(frequency)		 G-Allele
(frequency)		 T/T
(frequency)		 T/G
(frequency)		 G/G
(frequency)
 Caucasian 3 AD
CTR		 0.07
0.10		 0.93
0.91		 2 (0.004)
10 (0.014)		 67 (0.129)
119 (0.162)		 449 (0.867)
606 (0.824)
 Asian 1 AD
CTR		 0.05
0.11		 0.95
0.89		 0 (0.000)
1 (0.019)		 6 (0.103)
9 (0.173)		 52 (0.897)
42 (0.808)
Total 4 AD
CTR		 0.07
0.10		 0.93
0.91		 2 (0.003)
11 (0.014)		 73 (0.127)
128 (0.163)		 501 (0.870)
648 (0.823)

Meta-Analysis Methods      * New * Cumulative Meta-analysis
2) Forest plot for polymorphism  rs4845378

Please also see disclaimer for more information on these meta-analyses.

Meta-analyses have not been performed on the following polymorphisms since they lack published genotype data in at least four independent case-control samples, or the published genotype data was otherwise not eligible for inclusion (see methods for details):

A891C (Q397P)
C188G
C199G
rs11264222
rs1127314
rs2072660
rs2072661
rs3811450
rs4845652

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Top Results Details
1. APOE_e2/3/4
2. BIN1
3. CLU
4. ABCA7
5. CR1
6. PICALM
7. MS4A6A
8. CD33
9. MS4A4E
10. CD2AP
AlzGene Stats
Studies: 1395
Genes: 695
Polymorphisms: 2973
Meta-analyses: 320
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The PDGene database is supported by a grant from The Michael J. Fox Foundation in partnership with the Alzheimer Research Forum.

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The National Cell Repository for Alzheimer Disease seeks to recruit 1,000 families with two or more living brothers or sisters who have been diagnosed with late onset Alzheimer’s disease.
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An up-to-date collection of all published genetic association studies.