AlzGene - Meta-Analysis of All Published AD Association Studies (Case-Control Only) rs1800764
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 Polymorphism: rs1800764 (ACE7)
 Gene: ACE  (DCP; DCP1; CD143; MGC26566; ACE1)  Entrez Gene    View on ALSGene   View on MSGene   View on PDGene   View on SZGene
 Protein: angiotensin I converting enzyme (peptidyl-dipeptidase A) 1   ProteinLink
 Chromosome: 17   (View: 1  2  3  4  5  6  7  8  9  10  11  12  13  14  15  16  17  18  19  20  21  22  X  Y  MT)
 Status: Updated 18 April 2011
Gene Overview
 Polymorphism:
1) Summary of Allele and Genotype Distribution of all Published Association Studies (by Ethnic Group)
      Alleles Genotypes
  # Case-Control
Samples
  C-Allele
(frequency)
T-Allele
(frequency)
C/C
(frequency)
C/T
(frequency)
T/T
(frequency)
 Caucasian 7 AD
CTR
0.43
0.46
0.57
0.54
402 (0.186)
385 (0.217)
1049 (0.485)
873 (0.493)
712 (0.329)
513 (0.290)
 Asian 1 AD
CTR
0.48
0.44
0.52
0.56
23 (0.209)
93 (0.205)
59 (0.536)
215 (0.475)
28 (0.255)
145 (0.320)
 Other/Mixed 1 AD
CTR
0.63
0.61
0.37
0.39
37 (0.398)
62 (0.373)
43 (0.462)
79 (0.476)
13 (0.140)
25 (0.151)
Total 9 AD
CTR
0.44
0.47
0.56
0.53
462 (0.195)
540 (0.226)
1151 (0.486)
1167 (0.488)
753 (0.318)
683 (0.286)

Meta-Analysis Methods      * New * Cumulative Meta-analysis
2) Forest plot for polymorphism  rs1800764 (ACE7)

Please also see disclaimer for more information on these meta-analyses.


Meta-analyses have not been performed on the following polymorphisms since they lack published genotype data in at least four independent case-control samples, or the published genotype data was otherwise not eligible for inclusion (see methods for details):

ACE_240A/T
rs12451328
rs4293
rs4295
rs4305
rs4309 (ACE5)
rs4311
rs4329
rs4331 (ACE4)
rs4335
rs4351
rs4353
rs4363 (ACE1)
rs4459609
rs4461142
rs4575595
rs4646994
rs4978
rs8066276
rs867640
rs9914151

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AlzGene Stats
Studies: 1395
Genes: 695
Polymorphisms: 2973
Meta-analyses: 320
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The National Cell Repository for Alzheimer Disease seeks to recruit 1,000 families with two or more living brothers or sisters who have been diagnosed with late onset Alzheimer’s disease.
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An up-to-date collection of all published genetic association studies.