AlzGene - Meta-Analysis of All Published AD Association Studies (Case-Control Only) rs662
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 Polymorphism: rs662 (R192Q)
 Gene: PON1  (ESA; PON)  Entrez Gene    View on ALSGene   View on MSGene   View on PDGene   View on SZGene
 Protein: paraoxonase 1   ProteinLink
 Chromosome: 7   (View: 1  2  3  4  5  6  7  8  9  10  11  12  13  14  15  16  17  18  19  20  21  22  X  Y  MT)
 Status: Updated 18 April 2011
Gene Overview
 Polymorphism:
1) Summary of Allele and Genotype Distribution of all Published Association Studies (by Ethnic Group)
      Alleles Genotypes
  # Case-Control
Samples
  C (R)-Allele
(frequency)
T (Q)-Allele
(frequency)
C (R)/C (R)
(frequency)
C (R)/T (Q)
(frequency)
T (Q)/T (Q)
(frequency)
 Caucasian 6 AD
CTR
0.27
0.27
0.73
0.74
81 (0.073)
110 (0.079)
435 (0.390)
514 (0.371)
600 (0.538)
760 (0.549)
 Asian 3 AD
CTR
0.59
0.62
0.41
0.38
219 (0.363)
273 (0.391)
271 (0.449)
322 (0.461)
113 (0.187)
103 (0.148)
Total 9 AD
CTR
0.38
0.39
0.62
0.62
300 (0.175)
383 (0.184)
706 (0.411)
836 (0.402)
713 (0.415)
863 (0.415)

Meta-Analysis Methods      * New * Cumulative Meta-analysis
2) Forest plot for polymorphism  rs662 (R192Q)

Please also see disclaimer for more information on these meta-analyses.


Meta-analyses have not been performed on the following polymorphisms since they lack published genotype data in at least four independent case-control samples, or the published genotype data was otherwise not eligible for inclusion (see methods for details):

rs1157745
rs1859121
rs2237582
rs2269829
rs2299255
rs2299261
rs2375001
rs705379 (-107 promoter)
rs705381 (-161 promoter)
rs854560 (L55M)
rs854565
rs854565

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AlzGene Stats
Studies: 1395
Genes: 695
Polymorphisms: 2973
Meta-analyses: 320
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Michael J. Fox Foundation
The PDGene database is supported by a grant from The Michael J. Fox Foundation in partnership with the Alzheimer Research Forum.

NCRAD

The National Cell Repository for Alzheimer Disease seeks to recruit 1,000 families with two or more living brothers or sisters who have been diagnosed with late onset Alzheimer’s disease.
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An up-to-date collection of all published genetic association studies.