AlzGene - Meta-Analysis of All Published AD Association Studies (Case-Control Only) SERPINA3_A10
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 Polymorphism: SERPINA3_A10
 Gene: SERPINA3  (ACT; AACT; GIG24; GIG25)  Entrez Gene    View on PDGene   View on SZGene
 Protein: serpin peptidase inhibitor, clade A, member 3  (antichymotrypsin; alpha-1-antichymotrypsin)  ProteinLink
 Chromosome: 14   (View: 1  2  3  4  5  6  7  8  9  10  11  12  13  14  15  16  17  18  19  20  21  22  X  Y  MT)
 Status: Updated 18 April 2011
Gene Overview
 Polymorphism:
1) Summary of Allele and Genotype Distribution of all Published Association Studies (by Ethnic Group)
      Alleles Genotypes
  # Case-Control
Samples
  A10+-Allele
(frequency)
A10--Allele
(frequency)
A10+/A10+
(frequency)
A10+/A10-
(frequency)
A10-/A10-
(frequency)
 Caucasian 4 AD
CTR
0.49
0.45
0.51
0.55
152 (0.248)
90 (0.190)
295 (0.481)
247 (0.522)
166 (0.271)
136 (0.288)
Total 4 AD
CTR
0.49
0.45
0.51
0.55
152 (0.248)
90 (0.190)
295 (0.481)
247 (0.522)
166 (0.271)
136 (0.288)

Meta-Analysis Methods      * New * Cumulative Meta-analysis
2) Forest plot for polymorphism SERPINA3_A10

Please also see disclaimer for more information on these meta-analyses.


Meta-analyses have not been performed on the following polymorphisms since they lack published genotype data in at least four independent case-control samples, or the published genotype data was otherwise not eligible for inclusion (see methods for details):

ACT1_TG
Leu39Leu
Met389Val
rs10145747 (ACT1)
rs11538071 (Leu241Leu)
rs11625058 (ACT Intron 4)
rs17826488 (Pro227Ala)
rs1802958 (Thr324Thr)
rs1884082 (ACT4)
rs4375593 (ACT2)
rs4508366 (ACT3)
rs8004988
Ser250Ser
SERPINA3_promoter

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AlzGene Stats
Studies: 1395
Genes: 695
Polymorphisms: 2973
Meta-analyses: 320
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The PDGene database is supported by a grant from The Michael J. Fox Foundation in partnership with the Alzheimer Research Forum.

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The National Cell Repository for Alzheimer Disease seeks to recruit 1,000 families with two or more living brothers or sisters who have been diagnosed with late onset Alzheimer’s disease.
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An up-to-date collection of all published genetic association studies.