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AlzGene - Meta-Analysis of All Published AD Association Studies (Case-Control Only) rs8106922
Polymorphism:
rs8106922
Gene:
TOMM40
(TOM40; PEREC1; C19orf1; PER-EC1; D19S1177E)
View on MSGene
Protein:
translocase of outer mitochondrial membrane 40 homolog (yeast)
Chromosome:
19
(View:
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
X
Y
MT
)
Status:
Updated 18 April 2011
Polymorphism:
rs157580 (significant)
rs157581 (significant)
rs2075650 (significant)
rs8106922 (significant)
1) Summary of Allele and Genotype Distribution of all Published Association Studies (by Ethnic Group)
Alleles
Genotypes
# Case-Control
Samples
G-Allele
(frequency)
A-Allele
(frequency)
G/G
(frequency)
G/A
(frequency)
A/A
(frequency)
Caucasian
7
AD
CTR
0.30
0.40
0.70
0.60
684 (0.091)
1884 (0.163)
3176 (0.424)
5462 (0.472)
3623 (0.484)
4222 (0.365)
Total
7
AD
CTR
0.30
0.40
0.70
0.60
684 (0.091)
1884 (0.163)
3176 (0.424)
5462 (0.472)
3623 (0.484)
4222 (0.365)
Meta-Analysis Methods
* New *
Cumulative Meta-analysis
2) Forest plot for polymorphism
rs8106922
Please also
see disclaimer
for more information on these meta-analyses.
Meta-analyses have not been performed on the following polymorphisms since they lack published genotype data in at least four independent case-control samples, or the published genotype data was otherwise not eligible for inclusion (see
methods
for details):
19AyD0326
rs10119
rs1038025
rs1038026
rs10524523 (polyT VNTR)
rs11556505
rs1160983
rs1160985
rs1305062
rs157582
rs157583
rs157584
rs157585
rs157587
rs157588
rs157590
rs2075649
rs283817
rs34215622
rs34878901
rs394819
rs405697
rs434132
rs446037
rs573199
rs7256173
rs7259620
rs741780
rs760136
TOMM40_novel
AlzGene Recent Updates
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PICALM
MS4A6A
MS4A4A
MS4A4E
EPHA1
CR1
CLU
CD33
CD2AP
BIN1
ABCA7
ARID5B
CELF2
APOC4
BCAM
CLPTM1
PVRL2
LOC3884...
TNK1
MYH13
TOMM40
PCK1
SORL1
LMNA
PGBD1
UBD
GWA_7p1...
GAB2
GOLM1
GWA_15q...
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PCDH11X
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ATXN1
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PIK3R1
FYN
PPP1R3A
NDUFA8
MAPK8IP...
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IDE
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IREB2
HMGCR
IGF1R
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PPARGC1...
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IGF1
CSK
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CARD8
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NUMB
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OLIG2
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EFNA5
MAGI2
CAND1
PPIL2
CDKN2BA...
PTPLA
ACAT2
CHRNB4
DGKB
GWA_10q...
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GWA_3q2...
HPCAL1
EXOC3L2
GWA_3p2...
ZNF292
PATHWAY...
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TP63
TMEM132...
RGS6
NXPH1
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AlzGene Top Results
Top Results Details
1.
APOE_e2/3/4
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6.
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7.
MS4A6A
8.
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9.
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10.
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AlzGene Stats
Studies: 1395
Genes: 695
Polymorphisms: 2973
Meta-analyses: 320
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