AlzGene - Meta-Analysis of All Published AD Association Studies (Case-Control Only) rs2227566
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 Polymorphism: rs2227566
 Gene: PLAU  (UPA; URK)  Entrez Gene
 Protein: plasminogen activator, urokinase   ProteinLink
 Chromosome: 10   (View: 1  2  3  4  5  6  7  8  9  10  11  12  13  14  15  16  17  18  19  20  21  22  X  Y  MT)
 Status: Updated 18 April 2011
Gene Overview
 Polymorphism:
1) Summary of Allele and Genotype Distribution of all Published Association Studies (by Ethnic Group)
      Alleles Genotypes
  # Case-Control
Samples		   C-Allele
(frequency)		 T-Allele
(frequency)		 C/C
(frequency)		 C/T
(frequency)		 T/T
(frequency)
 Caucasian 7 AD
CTR		 0.48
0.44		 0.52
0.56		 230 (0.229)
207 (0.195)		 508 (0.505)
527 (0.497)		 268 (0.266)
326 (0.308)
 Asian 1 AD
CTR		 0.90
0.92		 0.10
0.08		 290 (0.810)
284 (0.850)		 63 (0.176)
45 (0.135)		 5 (0.014)
5 (0.015)
Total 8 AD
CTR		 0.59
0.56		 0.41
0.44		 520 (0.381)
491 (0.352)		 571 (0.419)
572 (0.410)		 273 (0.200)
331 (0.237)

Meta-Analysis Methods      * New * Cumulative Meta-analysis
2) Forest plot for polymorphism  rs2227566

Please also see disclaimer for more information on these meta-analyses.

Meta-analyses have not been performed on the following polymorphisms since they lack published genotype data in at least four independent case-control samples, or the published genotype data was otherwise not eligible for inclusion (see methods for details):

rs10762566
rs1916341
rs2227551
rs2227552
rs2227562
rs2227574
rs2227580
rs2227582
rs2459449
rs2461863
rs2633298
rs2633306
rs2633313
rs2633314
rs2633317
rs2633322
rs2675663
rs2675675
rs2675680
rs2688607
rs2688610
rs2688619
rs2688624
T-1966-C

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Top Results Details
1. APOE_e2/3/4
2. BIN1
3. CLU
4. ABCA7
5. CR1
6. PICALM
7. MS4A6A
8. CD33
9. MS4A4E
10. CD2AP
AlzGene Stats
Studies: 1395
Genes: 695
Polymorphisms: 2973
Meta-analyses: 320
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The National Cell Repository for Alzheimer Disease seeks to recruit 1,000 families with two or more living brothers or sisters who have been diagnosed with late onset Alzheimer’s disease.
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An up-to-date collection of all published genetic association studies.