AlzGene - Meta-Analysis of All Published AD Association Studies (Case-Control Only) rs3818361
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 Polymorphism: rs3818361
 Gene: CR1  (C3BR; C4BR; CD35; KN)  Entrez Gene    View on PDGene
 Protein: complement component (3b/4b) receptor 1 (Knops blood group)  (C3-binding protein; C3b/C4b receptor; CD35 antigen; Knops blood group antigen; complement component receptor 1; complement receptor 1)  ProteinLink
 Chromosome: 1   (View: 1  2  3  4  5  6  7  8  9  10  11  12  13  14  15  16  17  18  19  20  21  22  X  Y  MT)
 Status: Updated 18 April 2011
Gene Overview
 Polymorphism:
1) Summary of Allele and Genotype Distribution of all Published Association Studies (by Ethnic Group)
      Alleles Genotypes
  # Case-Control
Samples		   T-Allele
(frequency)		 C-Allele
(frequency)		 T/T
(frequency)		 T/C
(frequency)		 C/C
(frequency)
 Asian 1 AD
CTR		 0.38
0.33		 0.62
0.67		 38 (0.150)
38 (0.106)		 118 (0.465)
161 (0.451)		 98 (0.386)
158 (0.443)
Total 1 AD
CTR		 no data available
no data available		 no data available
no data available		 (0)
(0)		 (0)
(0)		 (0)
(0)

Meta-Analysis Methods      * New * Cumulative Meta-analysis
2) Forest plot for polymorphism  rs3818361

Please also see disclaimer for more information on these meta-analyses.

Meta-analyses have not been performed on the following polymorphisms since they lack published genotype data in at least four independent case-control samples, or the published genotype data was otherwise not eligible for inclusion (see methods for details):

rs11118475
rs11118491
rs1359147
rs17049197
rs1977265
rs1998538
rs1998539
rs2104303
rs3849268
rs3927459
rs4844614
rs6661764
rs6667500

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Top Results Details
1. APOE_e2/3/4
2. BIN1
3. CLU
4. ABCA7
5. CR1
6. PICALM
7. MS4A6A
8. CD33
9. MS4A4E
10. CD2AP
AlzGene Stats
Studies: 1395
Genes: 695
Polymorphisms: 2973
Meta-analyses: 320
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The PDGene database is supported by a grant from The Michael J. Fox Foundation in partnership with the Alzheimer Research Forum.

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The National Cell Repository for Alzheimer Disease seeks to recruit 1,000 families with two or more living brothers or sisters who have been diagnosed with late onset Alzheimer’s disease.
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An up-to-date collection of all published genetic association studies.