AlzGene - Meta-Analysis of All Published AD Association Studies (Case-Control Only) rs2230808
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 Polymorphism: rs2230808 (R1587K)
 Gene: ABCA1  (TGD; ABC1; CERP; ABC-1; HDLDT1)  Entrez Gene
 Protein: ATP-binding cassette, sub-family A member 1  (ATP binding cassette transporter 1; cholesterol efflux regulatory protein; high density lipoprotein deficiency, Tangier type, 1; ATP-binding cassette 1)  ProteinLink
 Chromosome: 9   (View: 1  2  3  4  5  6  7  8  9  10  11  12  13  14  15  16  17  18  19  20  21  22  X  Y  MT)
 Status: Updated 18 April 2011
Gene Overview
 Polymorphism:
1) Summary of Allele and Genotype Distribution of all Published Association Studies (by Ethnic Group)
      Alleles Genotypes
  # Case-Control
Samples		   A-Allele
(frequency)		 G-Allele
(frequency)		 A/A
(frequency)		 A/G
(frequency)		 G/G
(frequency)
 Caucasian 9 AD
CTR		 0.24
0.22		 0.76
0.78		 197 (0.056)
154 (0.052)		 1272 (0.362)
1031 (0.345)		 2045 (0.582)
1803 (0.603)
 Asian 1 AD
CTR		 0.49
0.42		 0.51
0.58		 62 (0.229)
44 (0.158)		 140 (0.517)
146 (0.525)		 69 (0.255)
88 (0.317)
Total 10 AD
CTR		 0.26
0.24		 0.75
0.76		 259 (0.068)
198 (0.061)		 1412 (0.373)
1177 (0.360)		 2114 (0.559)
1891 (0.579)

Meta-Analysis Methods      * New * Cumulative Meta-analysis
2) Forest plot for polymorphism  rs2230808 (R1587K)

Please also see disclaimer for more information on these meta-analyses.

Meta-analyses have not been performed on the following polymorphisms since they lack published genotype data in at least four independent case-control samples, or the published genotype data was otherwise not eligible for inclusion (see methods for details):

hcv2741108
rs10120087
rs10820743
rs10991414
rs1175293
rs11789603
rs12350560
rs1800977 (C-14T)
rs1883025
rs1929841
rs2020926
rs2020927
rs2043664
rs2065412
rs2066715
rs2066716
rs2066717
rs2066881
rs2230805
rs2243312
rs2246293
rs2254884
rs2274873
rs2297402
rs2297404
rs2297406
rs2297409
rs2422493 (C-477T)
rs2437811
rs2472377
rs2472384
rs2472386
rs2472496
rs2482433
rs2487039
rs2487042
rs2487054
rs2515601
rs2575875
rs2575876
rs2575879
rs2740483
rs2740485
rs2740487
rs2777793
rs2777799
rs2777801
rs33918808
rs363717
rs3858074
rs3887137
rs3890182
rs3905001
rs4149262
rs4149263
rs4149264
rs4149265
rs4149268
rs4149271
rs4149291
rs4149312
rs4149336
rs4149338
rs6479283

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AlzGene Stats
Studies: 1395
Genes: 695
Polymorphisms: 2973
Meta-analyses: 320
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An up-to-date collection of all published genetic association studies.