AlzGene - Polymorphism Details
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 Study: Akomolafe, 2006
 Gene: NOS3   Entrez Gene    View on ALSGene   View on MSGene   View on PDGene   View on SZGene
 Protein: nitric oxide synthase 3 (endothelial cell)   ProteinLink
 Chromosome: 7   (View: 1  2  3  4  5  6  7  8  9  10  11  12  13  14  15  16  17  18  19  20  21  22  X  Y  MT)
 Status: Updated 18 April 2011
Meta-Analysis     Gene Overview
Total number of polymorphisms investigated by this study: 11

Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   T-Allele G-Allele T/T
(frequency)		 T/G
(frequency)		 G/G
(frequency)
 African Descent
rs1799983 (E298D) USA AD
CTR		 0.09
0.16		 0.91
0.84		 0 (0.000)
1 (0.012)		 42 (0.179)
25 (0.305)		 193 (0.821)
56 (0.683)
 Caucasian
rs1799983 (E298D) Mixed AD
CTR		 0.35
0.30		 0.65
0.70		 31 (0.120)
11 (0.087)		 119 (0.459)
55 (0.433)		 109 (0.421)
61 (0.480)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   A-Allele T-Allele A/A
(frequency)		 A/T
(frequency)		 T/T
(frequency)
 African Descent
rs1800783 USA AD
CTR		 0.50
0.46		 0.50
0.54		 106 (0.358)
16 (0.195)		 82 (0.277)
43 (0.524)		 108 (0.365)
23 (0.280)
 Caucasian
rs1800783 Mixed AD
CTR		 0.39
0.36		 0.61
0.64		 34 (0.130)
17 (0.134)		 135 (0.515)
58 (0.457)		 93 (0.355)
52 (0.409)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   G-Allele A-Allele G/G
(frequency)		 G/A
(frequency)		 A/A
(frequency)
 African Descent
rs1800779 USA AD
CTR		 0.14
0.18		 0.86
0.82		 5 (0.021)
0 (0.000)		 56 (0.238)
29 (0.354)		 174 (0.740)
53 (0.646)
 Caucasian
rs1800779 Mixed AD
CTR		 0.38
0.36		 0.62
0.64		 31 (0.121)
17 (0.132)		 135 (0.525)
60 (0.465)		 91 (0.354)
52 (0.403)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   A-Allele G-Allele A/A
(frequency)		 A/G
(frequency)		 G/G
(frequency)
 African Descent
rs3918166 USA AD
CTR		 0.03
0.05		 0.97
0.95		 0 (0.000)
1 (0.012)		 16 (0.069)
6 (0.073)		 216 (0.931)
75 (0.915)
 Caucasian
rs3918166 Mixed AD
CTR		 0.00
0.00		 1.00
1.00		 0 (0.000)
0 (0.000)		 0 (0.000)
0 (0.000)		 259 (1.000)
127 (1.000)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   G-Allele A-Allele G/G
(frequency)		 G/A
(frequency)		 A/A
(frequency)
 African Descent
rs1007311 USA AD
CTR		 0.57
0.49		 0.43
0.51		 78 (0.335)
21 (0.256)		 108 (0.464)
39 (0.476)		 47 (0.202)
22 (0.268)
 Caucasian
rs1007311 Mixed AD
CTR		 0.42
0.43		 0.58
0.57		 49 (0.189)
34 (0.268)		 117 (0.452)
41 (0.323)		 93 (0.359)
52 (0.409)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   A-Allele G-Allele A/A
(frequency)		 A/G
(frequency)		 G/G
(frequency)
 African Descent
rs1800780 USA AD
CTR		 0.40
0.53		 0.60
0.47		 31 (0.131)
21 (0.256)		 125 (0.530)
45 (0.549)		 80 (0.339)
16 (0.195)
 Caucasian
rs1800780 Mixed AD
CTR		 0.45
0.50		 0.55
0.50		 57 (0.220)
38 (0.297)		 119 (0.459)
52 (0.406)		 83 (0.320)
38 (0.297)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   T-Allele G-Allele T/T
(frequency)		 T/G
(frequency)		 G/G
(frequency)
 African Descent
rs3918188 USA AD
CTR		 0.38
0.32		 0.62
0.68		 40 (0.169)
9 (0.110)		 101 (0.426)
35 (0.427)		 96 (0.405)
38 (0.463)
 Caucasian
rs3918188 Mixed AD
CTR		 0.34
0.36		 0.66
0.64		 28 (0.109)
22 (0.173)		 119 (0.461)
48 (0.378)		 111 (0.430)
57 (0.449)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   G-Allele A-Allele G/G
(frequency)		 G/A
(frequency)		 A/A
(frequency)
 African Descent
rs743506 USA AD
CTR		 0.42
0.41		 0.58
0.59		 42 (0.179)
10 (0.122)		 113 (0.481)
47 (0.573)		 80 (0.340)
25 (0.305)
 Caucasian
rs743506 Mixed AD
CTR		 0.24
0.28		 0.76
0.72		 13 (0.050)
8 (0.063)		 98 (0.378)
56 (0.438)		 148 (0.571)
64 (0.500)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   G-Allele A-Allele G/G
(frequency)		 G/A
(frequency)		 A/A
(frequency)
 African Descent
rs743507 USA AD
CTR		 0.22
0.22		 0.78
0.78		 19 (0.081)
3 (0.036)		 66 (0.281)
30 (0.361)		 150 (0.638)
50 (0.602)
 Caucasian
rs743507 Mixed AD
CTR		 0.24
0.29		 0.76
0.71		 13 (0.051)
8 (0.063)		 98 (0.383)
57 (0.449)		 145 (0.566)
62 (0.488)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   A-Allele G-Allele A/A
(frequency)		 A/G
(frequency)		 G/G
(frequency)
 African Descent
rs891512 USA AD
CTR		 0.03
0.07		 0.97
0.93		 0 (0.000)
0 (0.000)		 14 (0.060)
11 (0.134)		 221 (0.940)
71 (0.866)
 Caucasian
rs891512 Mixed AD
CTR		 0.21
0.22		 0.79
0.78		 10 (0.039)
8 (0.062)		 85 (0.332)
41 (0.318)		 161 (0.629)
80 (0.620)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   C-Allele G-Allele C/C
(frequency)		 C/G
(frequency)		 G/G
(frequency)
 African Descent
rs1077872 USA AD
CTR		 0.51
0.48		 0.49
0.52		 63 (0.268)
17 (0.207)		 113 (0.481)
44 (0.537)		 59 (0.251)
21 (0.256)
 Caucasian
rs1077872 Mixed AD
CTR		 0.31
0.37		 0.69
0.63		 28 (0.109)
17 (0.135)		 106 (0.411)
58 (0.460)		 124 (0.481)
51 (0.405)


Family-Based Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   T-Allele G-Allele T/T
(frequency)		 T/G
(frequency)		 G/G
(frequency)
 African Descent
rs1799983 (E298D) Overlaps with case-control sample AD
CTR		 -
-		 -
-		 0 (-)
0 (-)		 0 (-)
0 (-)		 0 (-)
0 (-)
 Caucasian
rs1799983 (E298D) Overlaps with case-control sample AD
CTR		 -
-		 -
-		 0 (-)
0 (-)		 0 (-)
0 (-)		 0 (-)
0 (-)
(-) :  Either no data provided, or data otherwise not eligible for inclusion (see methods for details).

Family-Based Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   A-Allele T-Allele A/A
(frequency)		 A/T
(frequency)		 T/T
(frequency)
 African Descent
rs1800783 Overlaps with case-control sample AD
CTR		 -
-		 -
-		 0 (-)
0 (-)		 0 (-)
0 (-)		 0 (-)
0 (-)
 Caucasian
rs1800783 Overlaps with case-control sample AD
CTR		 -
-		 -
-		 0 (-)
0 (-)		 0 (-)
0 (-)		 0 (-)
0 (-)
(-) :  Either no data provided, or data otherwise not eligible for inclusion (see methods for details).

Family-Based Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   G-Allele A-Allele G/G
(frequency)		 G/A
(frequency)		 A/A
(frequency)
 African Descent
rs1800779 Overlaps with case-control sample AD
CTR		 -
-		 -
-		 0 (-)
0 (-)		 0 (-)
0 (-)		 0 (-)
0 (-)
rs1800779 Overlaps with case-control sample AD
CTR		 -
-		 -
-		 0 (-)
0 (-)		 0 (-)
0 (-)		 0 (-)
0 (-)
 Caucasian
rs1800779 Overlaps with case-control sample AD
CTR		 -
-		 -
-		 0 (-)
0 (-)		 0 (-)
0 (-)		 0 (-)
0 (-)
(-) :  Either no data provided, or data otherwise not eligible for inclusion (see methods for details).

Family-Based Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   A-Allele G-Allele A/A
(frequency)		 A/G
(frequency)		 G/G
(frequency)
 African Descent
rs3918166 Overlaps with case-control sample AD
CTR		 -
-		 -
-		 0 (-)
0 (-)		 0 (-)
0 (-)		 0 (-)
0 (-)
 Caucasian
rs3918166 Overlaps with case-control sample AD
CTR		 -
-		 -
-		 0 (-)
0 (-)		 0 (-)
0 (-)		 0 (-)
0 (-)
(-) :  Either no data provided, or data otherwise not eligible for inclusion (see methods for details).

Family-Based Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   G-Allele A-Allele G/G
(frequency)		 G/A
(frequency)		 A/A
(frequency)
 African Descent
rs1007311 Overlaps with case-control sample AD
CTR		 -
-		 -
-		 0 (-)
0 (-)		 0 (-)
0 (-)		 0 (-)
0 (-)
 Caucasian
rs1007311 Overlaps with case-control sample AD
CTR		 -
-		 -
-		 0 (-)
0 (-)		 0 (-)
0 (-)		 0 (-)
0 (-)
(-) :  Either no data provided, or data otherwise not eligible for inclusion (see methods for details).

Family-Based Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   A-Allele G-Allele A/A
(frequency)		 A/G
(frequency)		 G/G
(frequency)
 African Descent
rs1800780 Overlaps with case-control sample AD
CTR		 -
-		 -
-		 0 (-)
0 (-)		 0 (-)
0 (-)		 0 (-)
0 (-)
 Caucasian
rs1800780 Overlaps with case-control sample AD
CTR		 -
-		 -
-		 0 (-)
0 (-)		 0 (-)
0 (-)		 0 (-)
0 (-)
(-) :  Either no data provided, or data otherwise not eligible for inclusion (see methods for details).

Family-Based Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   T-Allele G-Allele T/T
(frequency)		 T/G
(frequency)		 G/G
(frequency)
 African Descent
rs3918188 Overlaps with case-control sample AD
CTR		 -
-		 -
-		 0 (-)
0 (-)		 0 (-)
0 (-)		 0 (-)
0 (-)
 Caucasian
rs3918188 Overlaps with case-control sample AD
CTR		 -
-		 -
-		 0 (-)
0 (-)		 0 (-)
0 (-)		 0 (-)
0 (-)
(-) :  Either no data provided, or data otherwise not eligible for inclusion (see methods for details).

Family-Based Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   G-Allele A-Allele G/G
(frequency)		 G/A
(frequency)		 A/A
(frequency)
 African Descent
rs743506 Overlaps with case-control sample AD
CTR		 -
-		 -
-		 0 (-)
0 (-)		 0 (-)
0 (-)		 0 (-)
0 (-)
 Caucasian
rs743506 Overlaps with case-control sample AD
CTR		 -
-		 -
-		 0 (-)
0 (-)		 0 (-)
0 (-)		 0 (-)
0 (-)
(-) :  Either no data provided, or data otherwise not eligible for inclusion (see methods for details).

Family-Based Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   G-Allele A-Allele G/G
(frequency)		 G/A
(frequency)		 A/A
(frequency)
 African Descent
rs743507 Overlaps with case-control sample AD
CTR		 -
-		 -
-		 0 (-)
0 (-)		 0 (-)
0 (-)		 0 (-)
0 (-)
 Caucasian
rs743507 Overlaps with case-control sample AD
CTR		 -
-		 -
-		 0 (-)
0 (-)		 0 (-)
0 (-)		 0 (-)
0 (-)
(-) :  Either no data provided, or data otherwise not eligible for inclusion (see methods for details).

Family-Based Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   A-Allele G-Allele A/A
(frequency)		 A/G
(frequency)		 G/G
(frequency)
 African Descent
rs891512 Overlaps with case-control sample AD
CTR		 -
-		 -
-		 0 (-)
0 (-)		 0 (-)
0 (-)		 0 (-)
0 (-)
 Caucasian
rs891512 Overlaps with case-control sample AD
CTR		 -
-		 -
-		 0 (-)
0 (-)		 0 (-)
0 (-)		 0 (-)
0 (-)
(-) :  Either no data provided, or data otherwise not eligible for inclusion (see methods for details).

Family-Based Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   C-Allele G-Allele C/C
(frequency)		 C/G
(frequency)		 G/G
(frequency)
 African Descent
rs1077872 Overlaps with case-control sample AD
CTR		 -
-		 -
-		 0 (-)
0 (-)		 0 (-)
0 (-)		 0 (-)
0 (-)
 Caucasian
rs1077872 Overlaps with case-control sample AD
CTR		 -
-		 -
-		 0 (-)
0 (-)		 0 (-)
0 (-)		 0 (-)
0 (-)
(-) :  Either no data provided, or data otherwise not eligible for inclusion (see methods for details).
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