AlzGene - Polymorphism Details
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 Study: Helbecque, 2009
 Gene: ACE  (DCP; DCP1; CD143; MGC26566; ACE1)  Entrez Gene    View on ALSGene   View on MSGene   View on PDGene   View on SZGene
 Protein: angiotensin I converting enzyme (peptidyl-dipeptidase A) 1   ProteinLink
 Chromosome: 17   (View: 1  2  3  4  5  6  7  8  9  10  11  12  13  14  15  16  17  18  19  20  21  22  X  Y  MT)
 Status: Updated 18 April 2011
Meta-Analysis     Gene Overview
Total number of polymorphisms investigated by this study: 3

Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)
Population   ins-Allele del-Allele ins/ins
(frequency)
ins/del
(frequency)
del/del
(frequency)
 Caucasian
rs1799752 (intron 16 ins/del) Overlaps with Richard, 2001 AD
CTR
-
-
-
-
0 (-)
0 (-)
0 (-)
0 (-)
0 (-)
0 (-)
(-) :  Either no data provided, or data otherwise not eligible for inclusion (see methods for details).

Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)
Population   G-Allele A-Allele G/G
(frequency)
G/A
(frequency)
A/A
(frequency)
 Caucasian
rs4343 (ACE3) Overlaps with Richard, 2001 AD
CTR
0.46
0.46
0.54
0.54
75 (0.199)
92 (0.207)
196 (0.521)
228 (0.514)
105 (0.279)
124 (0.279)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)
Population   T-Allele A-Allele T/T
(frequency)
T/A
(frequency)
A/A
(frequency)
 Caucasian
rs4291 (ACE6) Overlaps with Richard, 2001 AD
CTR
0.37
0.41
0.63
0.59
44 (0.117)
65 (0.146)
187 (0.497)
234 (0.527)
145 (0.386)
145 (0.327)
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Studies: 1395
Genes: 695
Polymorphisms: 2973
Meta-analyses: 320
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The PDGene database is supported by a grant from The Michael J. Fox Foundation in partnership with the Alzheimer Research Forum.

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The National Cell Repository for Alzheimer Disease seeks to recruit 1,000 families with two or more living brothers or sisters who have been diagnosed with late onset Alzheimer’s disease.
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An up-to-date collection of all published genetic association studies.