AlzGene - Polymorphism Details
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 Study: Kehoe, 2003
 Gene: ACE  (DCP; DCP1; CD143; MGC26566; ACE1)  Entrez Gene    View on ALSGene   View on MSGene   View on PDGene   View on SZGene
 Protein: angiotensin I converting enzyme (peptidyl-dipeptidase A) 1   ProteinLink
 Chromosome: 17   (View: 1  2  3  4  5  6  7  8  9  10  11  12  13  14  15  16  17  18  19  20  21  22  X  Y  MT)
 Status: Updated 18 April 2011
Meta-Analysis     Gene Overview
Total number of polymorphisms investigated by this study: 8

Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)
Population   ins-Allele del-Allele ins/ins
(frequency)
ins/del
(frequency)
del/del
(frequency)
 Caucasian
rs1799752 (intron 16 ins/del) UK (Set D) AD
CTR
0.48
0.46
0.52
0.54
77 (0.231)
24 (0.220)
163 (0.489)
52 (0.477)
93 (0.279)
33 (0.303)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)
Population   G-Allele A-Allele G/G
(frequency)
G/A
(frequency)
A/A
(frequency)
 Caucasian
rs4343 (ACE3) Sweden (Set A) AD
CTR
-
-
-
-
0 (-)
0 (-)
0 (-)
0 (-)
0 (-)
0 (-)
rs4343 (ACE3) Sweden (Set C) AD
CTR
0.48
0.52
0.52
0.48
42 (0.233)
84 (0.261)
88 (0.489)
167 (0.519)
50 (0.278)
71 (0.220)
rs4343 (ACE3) UK (Set D) AD
CTR
0.51
0.54
0.49
0.46
81 (0.249)
33 (0.311)
167 (0.514)
49 (0.462)
77 (0.237)
24 (0.226)
rs4343 (ACE3) Scotland (Set B) AD
CTR
0.46
0.51
0.54
0.49
18 (0.154)
37 (0.247)
71 (0.607)
80 (0.533)
28 (0.239)
33 (0.220)
(-) :  Either no data provided, or data otherwise not eligible for inclusion (see methods for details).

Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)
Population   T-Allele A-Allele T/T
(frequency)
T/A
(frequency)
A/A
(frequency)
 Caucasian
rs4291 (ACE6) Scotland (Set B) AD
CTR
0.34
0.38
0.66
0.62
13 (0.111)
23 (0.154)
54 (0.462)
68 (0.456)
50 (0.427)
58 (0.389)
rs4291 (ACE6) Sweden (Set A) AD
CTR
0.35
0.39
0.65
0.61
23 (0.114)
28 (0.161)
94 (0.468)
80 (0.460)
84 (0.418)
66 (0.379)
rs4291 (ACE6) UK (Set D) AD
CTR
0.36
0.42
0.64
0.58
42 (0.132)
21 (0.196)
142 (0.448)
48 (0.449)
133 (0.420)
38 (0.355)
rs4291 (ACE6) Sweden (Set C) AD
CTR
0.33
0.37
0.67
0.63
14 (0.079)
48 (0.150)
89 (0.503)
140 (0.439)
74 (0.418)
131 (0.411)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)
Population   C-Allele T-Allele C/C
(frequency)
C/T
(frequency)
T/T
(frequency)
 Caucasian
rs1800764 (ACE7) Sweden (Set C) AD
CTR
0.42
0.46
0.58
0.54
29 (0.160)
66 (0.208)
93 (0.514)
159 (0.502)
59 (0.326)
92 (0.290)
rs1800764 (ACE7) UK (Set D) AD
CTR
0.43
0.50
0.57
0.50
59 (0.186)
28 (0.267)
152 (0.479)
49 (0.467)
106 (0.334)
28 (0.267)
rs1800764 (ACE7) Sweden (Set A) AD
CTR
0.41
0.46
0.59
0.54
36 (0.179)
38 (0.218)
92 (0.458)
85 (0.489)
73 (0.363)
51 (0.293)
rs1800764 (ACE7) Scotland (Set B) AD
CTR
0.39
0.45
0.61
0.55
16 (0.134)
29 (0.192)
60 (0.504)
79 (0.523)
43 (0.361)
43 (0.285)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)
Population   G-Allele A-Allele G/G
(frequency)
G/A
(frequency)
A/A
(frequency)
 Caucasian
rs4363 (ACE1) Scotland (Set B) AD
CTR
-
-
-
-
0 (-)
0 (-)
0 (-)
0 (-)
0 (-)
0 (-)
rs4363 (ACE1) Sweden (Set A) AD
CTR
-
-
-
-
0 (-)
0 (-)
0 (-)
0 (-)
0 (-)
0 (-)
(-) :  Either no data provided, or data otherwise not eligible for inclusion (see methods for details).

Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)
Population   T-Allele C-Allele T/T
(frequency)
T/C
(frequency)
C/C
(frequency)
 Caucasian
rs4362 (ACE2) Sweden (Set A) AD
CTR
-
-
-
-
0 (-)
0 (-)
0 (-)
0 (-)
0 (-)
0 (-)
rs4362 (ACE2) Scotland (Set B) AD
CTR
-
-
-
-
0 (-)
0 (-)
0 (-)
0 (-)
0 (-)
0 (-)
(-) :  Either no data provided, or data otherwise not eligible for inclusion (see methods for details).

Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)
Population   G-Allele A-Allele G/G
(frequency)
G/A
(frequency)
A/A
(frequency)
 Caucasian
rs4331 (ACE4) Scotland (Set B) AD
CTR
-
-
-
-
0 (-)
0 (-)
0 (-)
0 (-)
0 (-)
0 (-)
rs4331 (ACE4) Sweden (Set A) AD
CTR
-
-
-
-
0 (-)
0 (-)
0 (-)
0 (-)
0 (-)
0 (-)
(-) :  Either no data provided, or data otherwise not eligible for inclusion (see methods for details).

Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)
Population   T-Allele C-Allele T/T
(frequency)
T/C
(frequency)
C/C
(frequency)
 Caucasian
rs4309 (ACE5) Sweden (Set A) AD
CTR
-
-
-
-
0 (-)
0 (-)
0 (-)
0 (-)
0 (-)
0 (-)
rs4309 (ACE5) Scotland (Set B) AD
CTR
-
-
-
-
0 (-)
0 (-)
0 (-)
0 (-)
0 (-)
0 (-)
(-) :  Either no data provided, or data otherwise not eligible for inclusion (see methods for details).
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Genes: 695
Polymorphisms: 2973
Meta-analyses: 320
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