AlzGene - Polymorphism Details
Back Search Methods Disclaimer Credits
 Study: Meng, 2006
 Gene: ACE  (DCP; DCP1; CD143; MGC26566; ACE1)  Entrez Gene    View on ALSGene   View on MSGene   View on PDGene   View on SZGene
 Protein: angiotensin I converting enzyme (peptidyl-dipeptidase A) 1   ProteinLink
 Chromosome: 17   (View: 1  2  3  4  5  6  7  8  9  10  11  12  13  14  15  16  17  18  19  20  21  22  X  Y  MT)
 Status: Updated 18 April 2011
Meta-Analysis     Gene Overview
Total number of polymorphisms investigated by this study: 12

Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   ins-Allele del-Allele ins/ins
(frequency)		 ins/del
(frequency)		 del/del
(frequency)
 Other/Mixed
rs1799752 (intron 16 ins/del) Israel AD
CTR		 0.27
0.31		 0.73
0.69		 7 (0.076)
16 (0.096)		 36 (0.391)
71 (0.428)		 49 (0.533)
79 (0.476)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   G-Allele A-Allele G/G
(frequency)		 G/A
(frequency)		 A/A
(frequency)
 Other/Mixed
rs4343 (ACE3) Israel AD
CTR		 0.42
0.18		 0.58
0.82		 16 (0.174)
5 (0.030)		 45 (0.489)
49 (0.295)		 31 (0.337)
112 (0.675)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   T-Allele A-Allele T/T
(frequency)		 T/A
(frequency)		 A/A
(frequency)
 Other/Mixed
rs4291 (ACE6) Israel AD
CTR		 0.36
0.33		 0.64
0.67		 12 (0.130)
18 (0.108)		 42 (0.457)
73 (0.440)		 38 (0.413)
75 (0.452)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   C-Allele T-Allele C/C
(frequency)		 C/T
(frequency)		 T/T
(frequency)
 Other/Mixed
rs1800764 (ACE7) Israel AD
CTR		 0.63
0.61		 0.37
0.39		 37 (0.398)
62 (0.373)		 43 (0.462)
79 (0.476)		 13 (0.140)
25 (0.151)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   T-Allele C-Allele T/T
(frequency)		 T/C
(frequency)		 C/C
(frequency)
 Other/Mixed
rs4362 (ACE2) Israel AD
CTR		 0.51
0.60		 0.49
0.40		 24 (0.261)
60 (0.359)		 46 (0.500)
80 (0.479)		 22 (0.239)
27 (0.162)


Case-Control Studies (by ethnic group)
  Genotypes*
Polymorphism ID#
(Link to NCBI)		 Population   C-Allele G-Allele C/C
(frequency)		 C/G
(frequency)		 G/G
(frequency)
 Other/Mixed
rs4295 Israel AD
CTR		 0.42
0.39		 0.58
0.61		 16 (0.174)
25 (0.151)		 45 (0.489)
79 (0.476)		 31 (0.337)
62 (0.373)
*Genotypes have been calculated from allele frequencies assuming Hardy-Weinberg equilibrium.

Case-Control Studies (by ethnic group)
  Genotypes*
Polymorphism ID#
(Link to NCBI)		 Population   T-Allele C-Allele T/T
(frequency)		 T/C
(frequency)		 C/C
(frequency)
 Other/Mixed
rs4311 Israel AD
CTR		 0.53
0.47		 0.47
0.53		 26 (0.283)
37 (0.222)		 46 (0.500)
83 (0.497)		 20 (0.217)
47 (0.281)
*Genotypes have been calculated from allele frequencies assuming Hardy-Weinberg equilibrium.

Case-Control Studies (by ethnic group)
  Genotypes*
Polymorphism ID#
(Link to NCBI)		 Population   G-Allele A-Allele G/G
(frequency)		 G/A
(frequency)		 A/A
(frequency)
 Other/Mixed
rs4329 Israel AD
CTR		 0.27
0.33		 0.73
0.67		 7 (0.076)
18 (0.108)		 36 (0.391)
73 (0.440)		 49 (0.533)
75 (0.452)
*Genotypes have been calculated from allele frequencies assuming Hardy-Weinberg equilibrium.

Case-Control Studies (by ethnic group)
  Genotypes*
Polymorphism ID#
(Link to NCBI)		 Population   A-Allele G-Allele A/A
(frequency)		 A/G
(frequency)		 G/G
(frequency)
 Other/Mixed
rs4335 Israel AD
CTR		 0.43
0.45		 0.57
0.55		 17 (0.185)
34 (0.205)		 45 (0.489)
82 (0.494)		 30 (0.326)
50 (0.301)
*Genotypes have been calculated from allele frequencies assuming Hardy-Weinberg equilibrium.

Case-Control Studies (by ethnic group)
  Genotypes*
Polymorphism ID#
(Link to NCBI)		 Population   A-Allele G-Allele A/A
(frequency)		 A/G
(frequency)		 G/G
(frequency)
 Other/Mixed
rs4351 Israel AD
CTR		 0.44
0.32		 0.56
0.68		 18 (0.196)
17 (0.102)		 45 (0.489)
72 (0.434)		 29 (0.315)
77 (0.464)
*Genotypes have been calculated from allele frequencies assuming Hardy-Weinberg equilibrium.

Case-Control Studies (by ethnic group)
  Genotypes*
Polymorphism ID#
(Link to NCBI)		 Population   A-Allele G-Allele A/A
(frequency)		 A/G
(frequency)		 G/G
(frequency)
 Other/Mixed
rs4575595 Israel AD
CTR		 0.37
0.30		 0.63
0.70		 13 (0.140)
15 (0.090)		 43 (0.462)
70 (0.422)		 37 (0.398)
81 (0.488)
*Genotypes have been calculated from allele frequencies assuming Hardy-Weinberg equilibrium.

Case-Control Studies (by ethnic group)
  Genotypes*
Polymorphism ID#
(Link to NCBI)		 Population   C-Allele T-Allele C/C
(frequency)		 C/T
(frequency)		 T/T
(frequency)
 Other/Mixed
rs4267385 Israel AD
CTR		 0.30
0.31		 0.70
0.69		 8 (0.087)
16 (0.096)		 39 (0.424)
71 (0.428)		 45 (0.489)
79 (0.476)
*Genotypes have been calculated from allele frequencies assuming Hardy-Weinberg equilibrium.
AlzGene Recent Updates
AlzGene Top Results
Top Results Details
1. APOE_e2/3/4
2. BIN1
3. CLU
4. ABCA7
5. CR1
6. PICALM
7. MS4A6A
8. CD33
9. MS4A4E
10. CD2AP
AlzGene Stats
Studies: 1395
Genes: 695
Polymorphisms: 2973
Meta-analyses: 320
Cure Alzheimer's Fund
Proud supporter of the AlzGene database.
Michael J. Fox Foundation
The PDGene database is supported by a grant from The Michael J. Fox Foundation in partnership with the Alzheimer Research Forum.

NCRAD
The National Cell Repository for Alzheimer Disease seeks to recruit 1,000 families with two or more living brothers or sisters who have been diagnosed with late onset Alzheimer’s disease.
ALSGene
AlzGene
MSGene
PDGene
SZGene
An up-to-date collection of all published genetic association studies.