AlzGene - Polymorphism Details
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 Study: Reiman, 2007
 Gene: ADAM10  (kuz; HsT18717; kuzbanian; MADM)  Entrez Gene
 Protein: a disintegrin and metalloproteinase domain 10   ProteinLink
 Chromosome: 15   (View: 1  2  3  4  5  6  7  8  9  10  11  12  13  14  15  16  17  18  19  20  21  22  X  Y  MT)
 Status: Updated 18 April 2011
Meta-Analysis     Gene Overview
Total number of polymorphisms investigated by this study: 21

Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   G-Allele C-Allele G/G
(frequency)		 G/C
(frequency)		 C/C
(frequency)
 Caucasian
rs605928 USA, Netherlands AD
CTR		 0.30
0.32		 0.70
0.68		 74 (0.087)
57 (0.104)		 364 (0.427)
236 (0.430)		 414 (0.486)
256 (0.466)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   G-Allele C-Allele G/G
(frequency)		 G/C
(frequency)		 C/C
(frequency)
 Caucasian
rs7161889 USA, Netherlands AD
CTR		 0.32
0.34		 0.68
0.66		 89 (0.104)
63 (0.115)		 368 (0.431)
241 (0.441)		 396 (0.464)
243 (0.444)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   G-Allele A-Allele G/G
(frequency)		 G/A
(frequency)		 A/A
(frequency)
 Caucasian
rs10518984 USA, Netherlands AD
CTR		 0.04
0.05		 0.96
0.95		 3 (0.004)
1 (0.002)		 63 (0.074)
56 (0.101)		 789 (0.923)
495 (0.897)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   G-Allele A-Allele G/G
(frequency)		 G/A
(frequency)		 A/A
(frequency)
 Caucasian
rs16940712 USA, Netherlands AD
CTR		 0.03
0.04		 0.97
0.96		 0 (0.000)
1 (0.002)		 47 (0.055)
39 (0.071)		 810 (0.945)
511 (0.927)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   A-Allele C-Allele A/A
(frequency)		 A/C
(frequency)		 C/C
(frequency)
 Caucasian
rs16940472 USA, Netherlands AD
CTR		 0.10
0.11		 0.90
0.89		 10 (0.012)
6 (0.011)		 145 (0.170)
107 (0.194)		 696 (0.818)
439 (0.795)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   C-Allele T-Allele C/C
(frequency)		 C/T
(frequency)		 T/T
(frequency)
 Caucasian
rs7164844 USA, Netherlands AD
CTR		 0.13
0.15		 0.87
0.85		 13 (0.015)
15 (0.027)		 195 (0.228)
136 (0.246)		 648 (0.757)
401 (0.726)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   T-Allele C-Allele T/T
(frequency)		 T/C
(frequency)		 C/C
(frequency)
 Caucasian
rs12437457 USA, Netherlands AD
CTR		 0.14
0.14		 0.86
0.86		 16 (0.019)
12 (0.022)		 215 (0.251)
130 (0.236)		 626 (0.730)
409 (0.742)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   C-Allele T-Allele C/C
(frequency)		 C/T
(frequency)		 T/T
(frequency)
 Caucasian
rs8029805 USA, Netherlands AD
CTR		 0.13
0.13		 0.87
0.87		 15 (0.018)
11 (0.020)		 195 (0.233)
120 (0.222)		 627 (0.749)
410 (0.758)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   T-Allele A-Allele T/T
(frequency)		 T/A
(frequency)		 A/A
(frequency)
 Caucasian
rs16940651 USA, Netherlands AD
CTR		 0.16
0.15		 0.84
0.85		 16 (0.019)
13 (0.024)		 233 (0.282)
136 (0.254)		 576 (0.698)
386 (0.721)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   G-Allele T-Allele G/G
(frequency)		 G/T
(frequency)		 T/T
(frequency)
 Caucasian
rs6494030 USA, Netherlands AD
CTR		 0.15
0.14		 0.85
0.86		 16 (0.019)
13 (0.024)		 225 (0.263)
131 (0.238)		 616 (0.719)
406 (0.738)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   C-Allele T-Allele C/C
(frequency)		 C/T
(frequency)		 T/T
(frequency)
 Caucasian
rs10851639 USA, Netherlands AD
CTR		 0.20
0.22		 0.80
0.78		 29 (0.034)
20 (0.037)		 282 (0.334)
201 (0.373)		 533 (0.632)
318 (0.590)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   T-Allele C-Allele T/T
(frequency)		 T/C
(frequency)		 C/C
(frequency)
 Caucasian
rs7166325 USA, Netherlands AD
CTR		 0.16
0.15		 0.84
0.85		 18 (0.022)
12 (0.022)		 234 (0.282)
140 (0.261)		 579 (0.697)
384 (0.716)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   G-Allele T-Allele G/G
(frequency)		 G/T
(frequency)		 T/T
(frequency)
 Caucasian
rs12913383 USA, Netherlands AD
CTR		 0.16
0.16		 0.84
0.84		 22 (0.026)
16 (0.029)		 224 (0.262)
139 (0.256)		 608 (0.712)
389 (0.715)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   C-Allele G-Allele C/C
(frequency)		 C/G
(frequency)		 G/G
(frequency)
 Caucasian
rs1869133 USA, Netherlands AD
CTR		 0.20
0.23		 0.80
0.77		 33 (0.039)
29 (0.053)		 281 (0.328)
193 (0.350)		 543 (0.634)
329 (0.597)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   T-Allele C-Allele T/T
(frequency)		 T/C
(frequency)		 C/C
(frequency)
 Caucasian
rs12324536 USA, Netherlands AD
CTR		 0.20
0.21		 0.80
0.79		 37 (0.044)
24 (0.044)		 264 (0.317)
183 (0.339)		 533 (0.639)
333 (0.617)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   C-Allele T-Allele C/C
(frequency)		 C/T
(frequency)		 T/T
(frequency)
 Caucasian
rs17269341 USA, Netherlands AD
CTR		 0.20
0.21		 0.80
0.79		 38 (0.045)
27 (0.051)		 260 (0.309)
168 (0.315)		 543 (0.646)
338 (0.634)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   G-Allele A-Allele G/G
(frequency)		 G/A
(frequency)		 A/A
(frequency)
 Caucasian
rs3751542 USA, Netherlands AD
CTR		 0.27
0.31		 0.73
0.69		 56 (0.065)
48 (0.087)		 346 (0.404)
248 (0.449)		 454 (0.530)
256 (0.464)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   G-Allele T-Allele G/G
(frequency)		 G/T
(frequency)		 T/T
(frequency)
 Caucasian
rs690 USA, Netherlands AD
CTR		 0.41
0.41		 0.59
0.59		 143 (0.167)
80 (0.146)		 420 (0.491)
286 (0.521)		 293 (0.342)
183 (0.333)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   C-Allele G-Allele C/C
(frequency)		 C/G
(frequency)		 G/G
(frequency)
 Caucasian
rs17190678 USA, Netherlands AD
CTR		 0.46
0.47		 0.54
0.53		 176 (0.207)
117 (0.213)		 437 (0.513)
280 (0.510)		 239 (0.281)
152 (0.277)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   C-Allele T-Allele C/C
(frequency)		 C/T
(frequency)		 T/T
(frequency)
 Caucasian
rs8028759 USA, Netherlands AD
CTR		 0.32
0.33		 0.68
0.67		 100 (0.117)
62 (0.113)		 353 (0.411)
239 (0.434)		 405 (0.472)
250 (0.454)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   G-Allele T-Allele G/G
(frequency)		 G/T
(frequency)		 T/T
(frequency)
 Caucasian
rs1968687 USA, Netherlands AD
CTR		 0.11
0.11		 0.89
0.89		 11 (0.013)
5 (0.009)		 170 (0.198)
115 (0.209)		 676 (0.789)
431 (0.782)
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AlzGene Stats
Studies: 1395
Genes: 695
Polymorphisms: 2973
Meta-analyses: 320
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