AlzGene - Polymorphism Details
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 Study: Butler, 2009
 Gene: CYP19A1  (ARO; CYAR; CYP19; P-450AROM; CPV1; ARO1)  Entrez Gene    View on PDGene
 Protein: cytochrome P450, family 19, subfamily A, polypeptide 1   ProteinLink
 Chromosome: 15   (View: 1  2  3  4  5  6  7  8  9  10  11  12  13  14  15  16  17  18  19  20  21  22  X  Y  MT)
 Status: Updated 18 April 2011
Meta-Analysis     Gene Overview
Total number of polymorphisms investigated by this study: 9

Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   T-Allele C-Allele T/T
(frequency)		 T/C
(frequency)		 C/C
(frequency)
 Caucasian
rs1004984 (SNP1) UK (OPTIMA) AD
CTR		 0.38
0.36		 0.62
0.64		 29 (0.146)
28 (0.126)		 93 (0.470)
102 (0.459)		 76 (0.384)
92 (0.414)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   T-Allele C-Allele T/T
(frequency)		 T/C
(frequency)		 C/C
(frequency)
 Caucasian
rs1902586 (SNP3) UK (OPTIMA) AD
CTR		 0.05
0.05		 0.95
0.95		 0 (0.000)
0 (0.000)		 20 (0.105)
20 (0.090)		 171 (0.895)
201 (0.910)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   C-Allele T-Allele C/C
(frequency)		 C/T
(frequency)		 T/T
(frequency)
 Caucasian
rs1008805 (SNP4) UK (OPTIMA) AD
CTR		 0.41
0.46		 0.59
0.54		 32 (0.165)
46 (0.206)		 94 (0.485)
111 (0.498)		 68 (0.351)
66 (0.296)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   T-Allele C-Allele T/T
(frequency)		 T/C
(frequency)		 C/C
(frequency)
 Caucasian
rs767199 (SNP5) UK (OPTIMA) AD
CTR		 0.53
0.46		 0.47
0.54		 55 (0.278)
46 (0.209)		 99 (0.500)
109 (0.495)		 44 (0.222)
65 (0.295)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   G-Allele A-Allele G/G
(frequency)		 G/A
(frequency)		 A/A
(frequency)
 Caucasian
rs1065778 (SNP7) UK (OPTIMA) AD
CTR		 0.57
0.44		 0.43
0.56		 61 (0.319)
43 (0.194)		 94 (0.492)
110 (0.495)		 36 (0.188)
69 (0.311)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   T-Allele C-Allele T/T
(frequency)		 T/C
(frequency)		 C/C
(frequency)
 Caucasian
rs10046 (SNP9) UK (OPTIMA) AD
CTR		 0.59
0.49		 0.41
0.51		 58 (0.349)
41 (0.240)		 80 (0.482)
85 (0.497)		 28 (0.169)
45 (0.263)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   T-Allele C-Allele T/T
(frequency)		 T/C
(frequency)		 C/C
(frequency)
 Caucasian
rs700519 UK (OPTIMA) AD
CTR		 0.03
0.03		 0.97
0.97		 0 (0.000)
0 (0.000)		 12 (0.067)
10 (0.061)		 167 (0.933)
153 (0.939)


Case-Control Studies (by ethnic group)
  Genotypes*
Polymorphism ID#
(Link to NCBI)		 Population   SS-Allele LL-Allele SS/SS
(frequency)		 SS/LL
(frequency)		 LL/LL
(frequency)
 Caucasian
CYP19A1_STR (intron 4) UK (OPTIMA) AD
CTR		 0.57
0.45		 0.43
0.55		 68 (0.329)
47 (0.202)		 101 (0.488)
115 (0.494)		 38 (0.184)
71 (0.305)
*Genotypes have been calculated from allele frequencies assuming Hardy-Weinberg equilibrium.

Case-Control Studies (by ethnic group)
  Genotypes*
Polymorphism ID#
(Link to NCBI)		 Population   del-Allele ins-Allele del/del
(frequency)		 del/ins
(frequency)		 ins/ins
(frequency)
 Caucasian
rs11575899 UK (OPTIMA) AD
CTR		 0.29
0.40		 0.71
0.60		 17 (0.082)
37 (0.159)		 84 (0.406)
111 (0.476)		 106 (0.512)
85 (0.365)
*Genotypes have been calculated from allele frequencies assuming Hardy-Weinberg equilibrium.
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