AlzGene - Polymorphism Details
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 Study: Papassotiropoulos, 2006
 Gene: CH25H  (C25H)  Entrez Gene
 Protein: cholesterol 25-hydroxylase   ProteinLink
 Chromosome: 10   (View: 1  2  3  4  5  6  7  8  9  10  11  12  13  14  15  16  17  18  19  20  21  22  X  Y  MT)
 Status: Updated 18 April 2011
Meta-Analysis     Gene Overview
Total number of polymorphisms investigated by this study: 7

Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)
Population   A-Allele T-Allele A/A
(frequency)
A/T
(frequency)
T/T
(frequency)
 Caucasian
rs1131706 II (Switzerland) AD
CTR
-
-
-
-
0 (-)
0 (-)
0 (-)
0 (-)
0 (-)
0 (-)
rs1131706 I (Greece, Italy) AD
CTR
-
-
-
-
0 (-)
0 (-)
0 (-)
0 (-)
0 (-)
0 (-)
(-) :  Either no data provided, or data otherwise not eligible for inclusion (see methods for details).

Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)
Population   C-Allele T-Allele C/C
(frequency)
C/T
(frequency)
T/T
(frequency)
 Caucasian
rs4511206 (C-1710T) I (Greece, Italy) AD
CTR
-
-
-
-
0 (-)
0 (-)
0 (-)
0 (-)
0 (-)
0 (-)
rs4511206 (C-1710T) II (Switzerland) AD
CTR
-
-
-
-
0 (-)
0 (-)
0 (-)
0 (-)
0 (-)
0 (-)
(-) :  Either no data provided, or data otherwise not eligible for inclusion (see methods for details).

Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)
Population   A-Allele G-Allele A/A
(frequency)
A/G
(frequency)
G/G
(frequency)
 Caucasian
CH25H*4 (A-054G) II (Switzerland) AD
CTR
-
-
-
-
0 (-)
0 (-)
0 (-)
0 (-)
0 (-)
0 (-)
CH25H*4 (A-054G) I (Greece, Italy) AD
CTR
-
-
-
-
0 (-)
0 (-)
0 (-)
0 (-)
0 (-)
0 (-)
(-) :  Either no data provided, or data otherwise not eligible for inclusion (see methods for details).

Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)
Population   A-Allele G-Allele A/A
(frequency)
A/G
(frequency)
G/G
(frequency)
 Caucasian
CH25H*5 (A-44G) I (Greece, Italy) AD
CTR
-
-
-
-
0 (-)
0 (-)
0 (-)
0 (-)
0 (-)
0 (-)
CH25H*5 (A-44G) II (Switzerland) AD
CTR
-
-
-
-
0 (-)
0 (-)
0 (-)
0 (-)
0 (-)
0 (-)
(-) :  Either no data provided, or data otherwise not eligible for inclusion (see methods for details).

Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)
Population   T-Allele C-Allele T/T
(frequency)
T/C
(frequency)
C/C
(frequency)
 Caucasian
CH25H*6 (T503C) II (Switzerland) AD
CTR
-
-
-
-
0 (-)
0 (-)
0 (-)
0 (-)
0 (-)
0 (-)
CH25H*6 (T503C) I (Greece, Italy) AD
CTR
-
-
-
-
0 (-)
0 (-)
0 (-)
0 (-)
0 (-)
0 (-)
(-) :  Either no data provided, or data otherwise not eligible for inclusion (see methods for details).

Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)
Population   A-Allele G-Allele A/A
(frequency)
A/G
(frequency)
G/G
(frequency)
 Caucasian
CH25H*7 (A656G) I (Greece, Italy) AD
CTR
-
-
-
-
0 (-)
0 (-)
0 (-)
0 (-)
0 (-)
0 (-)
CH25H*7 (A656G) II (Switzerland) AD
CTR
-
-
-
-
0 (-)
0 (-)
0 (-)
0 (-)
0 (-)
0 (-)
(-) :  Either no data provided, or data otherwise not eligible for inclusion (see methods for details).

Case-Control Studies (by ethnic group)
  Genotypes*
Polymorphism ID#
(Link to NCBI)
Population   T-Allele C-Allele T/T
(frequency)
T/C
(frequency)
C/C
(frequency)
 Caucasian
rs13500 II (Switzerland) AD
CTR
0.13
0.07
0.87
0.93
3 (0.017)
1 (0.004)
38 (0.218)
38 (0.133)
133 (0.764)
246 (0.863)
rs13500 France AD
CTR
0.09
0.11
0.91
0.89
5 (0.009)
8 (0.012)
94 (0.171)
127 (0.191)
452 (0.820)
530 (0.797)
rs13500 Russia AD
CTR
0.14
0.07
0.86
0.93
1 (0.014)
0 (0.000)
18 (0.243)
12 (0.133)
55 (0.743)
78 (0.867)
rs13500 I (Greece, Italy) AD
CTR
0.13
0.08
0.87
0.92
4 (0.015)
1 (0.008)
61 (0.224)
17 (0.136)
207 (0.761)
107 (0.856)
 Other/Mixed
rs13500 USA (NIMH) AD
CTR
0.12
0.06
0.88
0.94
3 (0.014)
1 (0.007)
44 (0.209)
17 (0.116)
164 (0.777)
129 (0.878)
*Genotypes have been calculated from allele frequencies assuming Hardy-Weinberg equilibrium.

Family-Based Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)
Population   T-Allele C-Allele T/T
(frequency)
T/C
(frequency)
C/C
(frequency)
 Other/Mixed
rs13500 Overlaps with Schjeide, 2009 AD
CTR
-
-
-
-
0 (-)
0 (-)
0 (-)
0 (-)
0 (-)
0 (-)
(-) :  Either no data provided, or data otherwise not eligible for inclusion (see methods for details).
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Genes: 695
Polymorphisms: 2973
Meta-analyses: 320
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