AlzGene - Polymorphism Details
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 Study: Myers, 2006
 Gene: MAPT/STH  (TAU; MTBT2; FTDP-17; FLJ31424; MSTD; PPND; DDPAC; MAPTL; MTBT1; STH/MAPT)  Entrez Gene    View on ALSGene   View on MSGene   View on PDGene   View on SZGene
 Protein: microtubule-associated protein tau/saitohin  (microtubule-associated protein tau; saitohin)  ProteinLink
 Chromosome: 17   (View: 1  2  3  4  5  6  7  8  9  10  11  12  13  14  15  16  17  18  19  20  21  22  X  Y  MT)
 Status: Updated 18 April 2011 ;  Because of the complete correlation between genetic markers in MAPT and STH, these two loci have been combined for display in this database
Meta-Analysis     Gene Overview
Total number of polymorphisms investigated by this study: 6

Case-Control Studies (by ethnic group)
  Genotypes*
Polymorphism ID#
(Link to NCBI)
Population   H2-Allele H1-Allele H2/H2
(frequency)
H2/H1
(frequency)
H1/H1
(frequency)
 Caucasian
MAPT_H1H2 Overlaps with Schjeide, 2009 AD
CTR
0.24
0.21
0.76
0.79
17 (0.057)
6 (0.047)
108 (0.365)
42 (0.328)
171 (0.578)
80 (0.625)
*Genotypes have been calculated from allele frequencies assuming Hardy-Weinberg equilibrium.

Case-Control Studies (by ethnic group)
  Genotypes*
Polymorphism ID#
(Link to NCBI)
Population   G-Allele A-Allele G/G
(frequency)
G/A
(frequency)
A/A
(frequency)
 Caucasian
rs1467967 (promoter) Overlaps with Schjeide, 2009 AD
CTR
0.33
0.34
0.67
0.66
32 (0.108)
15 (0.117)
131 (0.443)
57 (0.445)
133 (0.449)
56 (0.438)
*Genotypes have been calculated from allele frequencies assuming Hardy-Weinberg equilibrium.

Case-Control Studies (by ethnic group)
  Genotypes*
Polymorphism ID#
(Link to NCBI)
Population   A-Allele G-Allele A/A
(frequency)
A/G
(frequency)
G/G
(frequency)
 Caucasian
rs242557 (promoter) Overlaps with Schjeide, 2009 AD
CTR
0.35
0.37
0.65
0.63
36 (0.122)
18 (0.140)
135 (0.456)
60 (0.465)
125 (0.422)
51 (0.395)
*Genotypes have been calculated from allele frequencies assuming Hardy-Weinberg equilibrium.

Case-Control Studies (by ethnic group)
  Genotypes*
Polymorphism ID#
(Link to NCBI)
Population   T-Allele C-Allele T/T
(frequency)
T/C
(frequency)
C/C
(frequency)
 Caucasian
rs2471738 (intron 9) Overlaps with Schjeide, 2009 AD
CTR
0.22
0.14
0.78
0.86
14 (0.047)
3 (0.023)
102 (0.345)
31 (0.240)
180 (0.608)
95 (0.736)
*Genotypes have been calculated from allele frequencies assuming Hardy-Weinberg equilibrium.

Case-Control Studies (by ethnic group)
  Genotypes*
Polymorphism ID#
(Link to NCBI)
Population   A-Allele G-Allele A/A
(frequency)
A/G
(frequency)
G/G
(frequency)
 Caucasian
rs3785883 (intron 3) Overlaps with Schjeide, 2009 AD
CTR
0.20
0.12
0.80
0.88
12 (0.041)
2 (0.016)
95 (0.321)
27 (0.211)
189 (0.639)
99 (0.773)
*Genotypes have been calculated from allele frequencies assuming Hardy-Weinberg equilibrium.

Case-Control Studies (by ethnic group)
  Genotypes*
Polymorphism ID#
(Link to NCBI)
Population   A-Allele G-Allele A/A
(frequency)
A/G
(frequency)
G/G
(frequency)
 Caucasian
rs7521 (3' UTR) Overlaps with Schjeide, 2009 AD
CTR
0.45
0.50
0.55
0.50
60 (0.202)
32 (0.250)
147 (0.495)
64 (0.500)
90 (0.303)
32 (0.250)
*Genotypes have been calculated from allele frequencies assuming Hardy-Weinberg equilibrium.
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Genes: 695
Polymorphisms: 2973
Meta-analyses: 320
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