AlzGene

AlzGene - Polymorphism Details

Study:

Feulner, 2009

Gene:

MAPT/STH (TAU; MTBT2; FTDP-17; FLJ31424; MSTD; PPND; DDPAC; MAPTL; MTBT1; STH/MAPT)

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Protein:

microtubule-associated protein tau/saitohin (microtubule-associated protein tau; saitohin)

Chromosome:

17 (View: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 X Y MT)

Status:

Updated 18 April 2011 ; Because of the complete correlation between genetic markers in MAPT and STH, these two loci have been combined for display in this database

Total number of polymorphisms investigated by this study: 20

Case-Control Studies (by ethnic group)
					Genotypes
Polymorphism ID# (Link to NCBI)	Population		G-Allele	A-Allele	G/G (frequency)	G/A (frequency)	A/A (frequency)
Caucasian
rs1467967 (promoter)	Germany	AD CTR	0.35 0.30	0.65 0.70	56 (0.114) 47 (0.098)	228 (0.464) 191 (0.399)	207 (0.422) 241 (0.503)

Case-Control Studies (by ethnic group)
					Genotypes
Polymorphism ID# (Link to NCBI)	Population		A-Allele	G-Allele	A/A (frequency)	A/G (frequency)	G/G (frequency)
Caucasian
rs242557 (promoter)	Germany	AD CTR	0.39 0.40	0.61 0.60	68 (0.138) 81 (0.169)	246 (0.501) 220 (0.459)	177 (0.360) 178 (0.372)

Case-Control Studies (by ethnic group)
					Genotypes
Polymorphism ID# (Link to NCBI)	Population		A-Allele	G-Allele	A/A (frequency)	A/G (frequency)	G/G (frequency)
Caucasian
rs3785883 (intron 3)	Germany	AD CTR	0.21 0.18	0.79 0.82	28 (0.057) 21 (0.044)	148 (0.301) 133 (0.278)	315 (0.642) 325 (0.678)

Case-Control Studies (by ethnic group)
					Genotypes
Polymorphism ID# (Link to NCBI)	Population		G-Allele	A-Allele	G/G (frequency)	G/A (frequency)	A/A (frequency)
Caucasian
rs1078997	Germany	AD CTR	0.19 0.17	0.81 0.83	20 (0.041) 17 (0.035)	144 (0.293) 125 (0.261)	327 (0.666) 337 (0.704)

Case-Control Studies (by ethnic group)
					Genotypes
Polymorphism ID# (Link to NCBI)	Population		G-Allele	A-Allele	G/G (frequency)	G/A (frequency)	A/A (frequency)
Caucasian
rs11867549	Germany	AD CTR	0.27 0.29	0.73 0.71	43 (0.088) 42 (0.088)	181 (0.369) 190 (0.397)	267 (0.544) 247 (0.516)

Case-Control Studies (by ethnic group)
					Genotypes
Polymorphism ID# (Link to NCBI)	Population		G-Allele	A-Allele	G/G (frequency)	G/A (frequency)	A/A (frequency)
Caucasian
rs16940742	Germany	AD CTR	0.07 0.08	0.93 0.92	3 (0.006) 5 (0.010)	58 (0.118) 66 (0.138)	430 (0.876) 408 (0.852)

Case-Control Studies (by ethnic group)
					Genotypes
Polymorphism ID# (Link to NCBI)	Population		G-Allele	A-Allele	G/G (frequency)	G/A (frequency)	A/A (frequency)
Caucasian
rs17563986	Germany	AD CTR	0.18 0.20	0.82 0.80	14 (0.029) 19 (0.040)	147 (0.299) 151 (0.315)	330 (0.672) 309 (0.645)

Case-Control Studies (by ethnic group)
					Genotypes
Polymorphism ID# (Link to NCBI)	Population		A-Allele	G-Allele	A/A (frequency)	A/G (frequency)	G/G (frequency)
Caucasian
rs1981997	Germany	AD CTR	0.18 0.20	0.82 0.80	13 (0.026) 19 (0.040)	147 (0.299) 151 (0.315)	331 (0.674) 309 (0.645)

Case-Control Studies (by ethnic group)
					Genotypes
Polymorphism ID# (Link to NCBI)	Population		G-Allele	A-Allele	G/G (frequency)	G/A (frequency)	A/A (frequency)
Caucasian
rs2258689	Germany	AD CTR	0.23 0.21	0.77 0.79	23 (0.047) 23 (0.048)	176 (0.358) 154 (0.322)	292 (0.595) 302 (0.630)

Case-Control Studies (by ethnic group)
					Genotypes
Polymorphism ID# (Link to NCBI)	Population		A-Allele	G-Allele	A/A (frequency)	A/G (frequency)	G/G (frequency)
Caucasian
rs2435200	Germany	AD CTR	0.39 0.39	0.61 0.61	66 (0.134) 75 (0.157)	247 (0.503) 221 (0.461)	178 (0.363) 183 (0.382)

Case-Control Studies (by ethnic group)
					Genotypes
Polymorphism ID# (Link to NCBI)	Population		G-Allele	A-Allele	G/G (frequency)	G/A (frequency)	A/A (frequency)
Caucasian
rs2435205	Germany	AD CTR	0.43 0.39	0.57 0.61	87 (0.178) 78 (0.163)	246 (0.502) 217 (0.453)	157 (0.320) 184 (0.384)

Case-Control Studies (by ethnic group)
					Genotypes
Polymorphism ID# (Link to NCBI)	Population		A-Allele	G-Allele	A/A (frequency)	A/G (frequency)	G/G (frequency)
Caucasian
rs2435211	Germany	AD CTR	0.30 0.32	0.70 0.68	43 (0.088) 47 (0.098)	213 (0.434) 208 (0.434)	235 (0.479) 224 (0.468)

Case-Control Studies (by ethnic group)
					Genotypes
Polymorphism ID# (Link to NCBI)	Population		C-Allele	A-Allele	C/C (frequency)	C/A (frequency)	A/A (frequency)
Caucasian
rs3785880	Germany	AD CTR	0.46 0.50	0.54 0.50	88 (0.179) 123 (0.257)	274 (0.558) 231 (0.482)	129 (0.263) 125 (0.261)

Case-Control Studies (by ethnic group)
					Genotypes
Polymorphism ID# (Link to NCBI)	Population		C-Allele	A-Allele	C/C (frequency)	C/A (frequency)	A/A (frequency)
Caucasian
rs4792891	Germany	AD CTR	0.34 0.32	0.66 0.68	58 (0.118) 54 (0.113)	213 (0.434) 200 (0.417)	220 (0.448) 226 (0.471)

Case-Control Studies (by ethnic group)
					Genotypes
Polymorphism ID# (Link to NCBI)	Population		A-Allele	G-Allele	A/A (frequency)	A/G (frequency)	G/G (frequency)
Caucasian
rs4792893	Germany	AD CTR	0.15 0.12	0.85 0.88	15 (0.031) 9 (0.019)	121 (0.246) 99 (0.207)	355 (0.723) 371 (0.775)

Case-Control Studies (by ethnic group)
					Genotypes
Polymorphism ID# (Link to NCBI)	Population		A-Allele	G-Allele	A/A (frequency)	A/G (frequency)	G/G (frequency)
Caucasian
rs4792894	Germany	AD CTR	0.13 0.12	0.87 0.88	11 (0.022) 9 (0.019)	109 (0.222) 93 (0.194)	371 (0.756) 377 (0.787)

Case-Control Studies (by ethnic group)
					Genotypes
Polymorphism ID# (Link to NCBI)	Population		A-Allele	G-Allele	A/A (frequency)	A/G (frequency)	G/G (frequency)
Caucasian
rs7220988	Germany	AD CTR	0.42 0.39	0.58 0.61	82 (0.167) 67 (0.140)	247 (0.504) 238 (0.497)	161 (0.329) 174 (0.363)

Case-Control Studies (by ethnic group)
					Genotypes
Polymorphism ID# (Link to NCBI)	Population		G-Allele	A-Allele	G/G (frequency)	G/A (frequency)	A/A (frequency)
Caucasian
rs8070723	Germany	AD CTR	0.18 0.20	0.82 0.80	13 (0.026) 19 (0.040)	148 (0.301) 151 (0.315)	330 (0.672) 309 (0.645)

Case-Control Studies (by ethnic group)
					Genotypes
Polymorphism ID# (Link to NCBI)	Population		A-Allele	G-Allele	A/A (frequency)	A/G (frequency)	G/G (frequency)
Caucasian
rs8078967	Germany	AD CTR	0.46 0.42	0.54 0.58	111 (0.226) 91 (0.190)	227 (0.462) 223 (0.467)	153 (0.312) 164 (0.343)

Case-Control Studies (by ethnic group)
					Genotypes
Polymorphism ID# (Link to NCBI)	Population		G-Allele	A-Allele	G/G (frequency)	G/A (frequency)	A/A (frequency)
Caucasian
rs8079215	Germany	AD CTR	0.30 0.29	0.70 0.71	35 (0.071) 41 (0.086)	228 (0.465) 192 (0.401)	227 (0.463) 246 (0.514)

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