AlzGene - Polymorphism Details
Back Search Methods Disclaimer Credits
 Study: Nowotny, 2007
 Gene: APP  (AAA; CTFgamma; ABETA; CVAP; APPI; ABPP; PN2; AD1)  Entrez Gene    View on SZGene
 Protein: amyloid beta (A4) precursor protein  (peptidase nexin-II)  ProteinLink
 Chromosome: 21   (View: 1  2  3  4  5  6  7  8  9  10  11  12  13  14  15  16  17  18  19  20  21  22  X  Y  MT)
 Status: Updated 1 May 2007
Meta-Analysis     Gene Overview
Total number of polymorphisms investigated by this study: 44

Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)
Population   G-Allele A-Allele G/G
(frequency)
G/A
(frequency)
A/A
(frequency)
 Caucasian
rs104173126 USA AD
CTR
0.43
0.44
0.57
0.56
109 (0.184)
103 (0.190)
286 (0.484)
272 (0.502)
196 (0.332)
167 (0.308)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)
Population   C-Allele T-Allele C/C
(frequency)
C/T
(frequency)
T/T
(frequency)
 Caucasian
rs1191028526 USA AD
CTR
0.06
0.06
0.94
0.94
3 (0.004)
3 (0.005)
79 (0.116)
60 (0.101)
597 (0.879)
532 (0.894)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)
Population   T-Allele C-Allele T/T
(frequency)
T/C
(frequency)
C/C
(frequency)
 Caucasian
rs178302626 USA AD
CTR
0.23
0.22
0.77
0.78
25 (0.047)
32 (0.058)
195 (0.364)
183 (0.330)
316 (0.590)
340 (0.613)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)
Population   C-Allele T-Allele C/C
(frequency)
C/T
(frequency)
T/T
(frequency)
 Caucasian
rs187606426 USA AD
CTR
0.25
0.25
0.75
0.75
33 (0.057)
29 (0.052)
222 (0.383)
226 (0.403)
324 (0.560)
306 (0.545)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)
Population   G-Allele A-Allele G/G
(frequency)
G/A
(frequency)
A/A
(frequency)
 Caucasian
rs200098926 USA AD
CTR
0.02
0.02
0.98
0.98
0 (0.000)
0 (0.000)
35 (0.050)
24 (0.039)
671 (0.950)
598 (0.961)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)
Population   C-Allele T-Allele C/C
(frequency)
C/T
(frequency)
T/T
(frequency)
 Caucasian
rs202622526 USA AD
CTR
0.29
0.26
0.71
0.74
60 (0.093)
39 (0.064)
257 (0.399)
241 (0.394)
327 (0.508)
331 (0.542)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)
Population   C-Allele A-Allele C/C
(frequency)
C/A
(frequency)
A/A
(frequency)
 Caucasian
rs205117426 USA AD
CTR
0.18
0.19
0.82
0.81
18 (0.032)
25 (0.048)
162 (0.289)
146 (0.283)
380 (0.679)
345 (0.669)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)
Population   A-Allele C-Allele A/A
(frequency)
A/C
(frequency)
C/C
(frequency)
 Caucasian
rs207065526 USA AD
CTR
0.31
0.29
0.69
0.71
64 (0.105)
49 (0.092)
246 (0.403)
212 (0.397)
301 (0.493)
273 (0.511)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)
Population   C-Allele T-Allele C/C
(frequency)
C/T
(frequency)
T/T
(frequency)
 Caucasian
rs21448826 USA AD
CTR
0.20
0.19
0.80
0.81
28 (0.047)
21 (0.039)
183 (0.307)
160 (0.297)
386 (0.647)
358 (0.664)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)
Population   A-Allele G-Allele A/A
(frequency)
A/G
(frequency)
G/G
(frequency)
 Caucasian
rs215607926 USA AD
CTR
0.24
0.26
0.76
0.74
32 (0.057)
43 (0.071)
206 (0.368)
230 (0.380)
322 (0.575)
332 (0.549)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)
Population   G-Allele C-Allele G/G
(frequency)
G/C
(frequency)
C/C
(frequency)
 Caucasian
rs21677326 USA AD
CTR
0.08
0.07
0.92
0.93
4 (0.007)
4 (0.008)
89 (0.153)
63 (0.122)
488 (0.840)
449 (0.870)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)
Population   G-Allele T-Allele G/G
(frequency)
G/T
(frequency)
T/T
(frequency)
 Caucasian
rs221177326 USA AD
CTR
0.36
0.36
0.64
0.64
75 (0.127)
63 (0.117)
275 (0.465)
264 (0.492)
242 (0.409)
210 (0.391)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)
Population   A-Allele G-Allele A/A
(frequency)
A/G
(frequency)
G/G
(frequency)
 Caucasian
rs223498826 USA AD
CTR
0.32
0.32
0.68
0.68
70 (0.100)
72 (0.117)
312 (0.446)
253 (0.413)
318 (0.454)
288 (0.470)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)
Population   T-Allele C-Allele T/T
(frequency)
T/C
(frequency)
C/C
(frequency)
 Caucasian
rs224268326 USA AD
CTR
0.41
0.40
0.59
0.60
94 (0.152)
74 (0.135)
316 (0.512)
287 (0.524)
207 (0.335)
187 (0.341)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)
Population   C-Allele G-Allele C/C
(frequency)
C/G
(frequency)
G/G
(frequency)
 Caucasian
rs224611526 USA AD
CTR
0.13
0.15
0.87
0.85
14 (0.023)
16 (0.030)
130 (0.214)
126 (0.239)
464 (0.763)
386 (0.731)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)
Population   C-Allele T-Allele C/C
(frequency)
C/T
(frequency)
T/T
(frequency)
 Caucasian
rs282996626 USA AD
CTR
0.47
0.48
0.53
0.52
126 (0.223)
122 (0.217)
284 (0.502)
300 (0.535)
156 (0.276)
139 (0.248)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)
Population   C-Allele T-Allele C/C
(frequency)
C/T
(frequency)
T/T
(frequency)
 Caucasian
rs282996826 USA AD
CTR
0.11
0.12
0.89
0.88
5 (0.008)
8 (0.015)
123 (0.201)
116 (0.211)
484 (0.791)
427 (0.775)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)
Population   T-Allele C-Allele T/T
(frequency)
T/C
(frequency)
C/C
(frequency)
 Caucasian
rs282998426 USA AD
CTR
0.12
0.11
0.88
0.89
9 (0.016)
4 (0.007)
119 (0.208)
107 (0.199)
445 (0.777)
426 (0.793)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)
Population   A-Allele G-Allele A/A
(frequency)
A/G
(frequency)
G/G
(frequency)
 Caucasian
rs283001226 USA AD
CTR
0.32
0.29
0.68
0.71
57 (0.093)
48 (0.086)
276 (0.452)
227 (0.405)
277 (0.454)
286 (0.510)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)
Population   C-Allele G-Allele C/C
(frequency)
C/G
(frequency)
G/G
(frequency)
 Caucasian
rs283002126 USA AD
CTR
0.36
0.35
0.64
0.65
75 (0.125)
72 (0.132)
279 (0.465)
240 (0.440)
246 (0.410)
234 (0.429)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)
Population   A-Allele T-Allele A/A
(frequency)
A/T
(frequency)
T/T
(frequency)
 Caucasian
rs283002526 USA AD
CTR
0.23
0.23
0.77
0.77
30 (0.047)
30 (0.053)
234 (0.366)
193 (0.344)
376 (0.588)
338 (0.602)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)
Population   C-Allele T-Allele C/C
(frequency)
C/T
(frequency)
T/T
(frequency)
 Caucasian
rs283002926 USA AD
CTR
0.25
0.25
0.75
0.75
33 (0.058)
27 (0.051)
221 (0.389)
211 (0.399)
314 (0.553)
291 (0.550)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)
Population   C-Allele T-Allele C/C
(frequency)
C/T
(frequency)
T/T
(frequency)
 Caucasian
rs283003026 USA AD
CTR
0.23
0.25
0.77
0.75
29 (0.048)
32 (0.061)
225 (0.371)
196 (0.376)
352 (0.581)
293 (0.562)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)
Population   C-Allele T-Allele C/C
(frequency)
C/T
(frequency)
T/T
(frequency)
 Caucasian
rs283003626 USA AD
CTR
0.22
0.23
0.78
0.77
27 (0.046)
31 (0.058)
201 (0.340)
182 (0.340)
363 (0.614)
323 (0.603)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)
Population   A-Allele G-Allele A/A
(frequency)
A/G
(frequency)
G/G
(frequency)
 Caucasian
rs283003826 USA AD
CTR
0.37
0.36
0.63
0.64
78 (0.133)
67 (0.123)
275 (0.468)
259 (0.476)
235 (0.400)
218 (0.401)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)
Population   C-Allele G-Allele C/C
(frequency)
C/G
(frequency)
G/G
(frequency)
 Caucasian
rs283004126 USA AD
CTR
0.31
0.30
0.69
0.70
54 (0.093)
47 (0.086)
253 (0.437)
230 (0.423)
272 (0.470)
267 (0.491)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)
Population   G-Allele A-Allele G/G
(frequency)
G/A
(frequency)
A/A
(frequency)
 Caucasian
rs283004526 USA AD
CTR
0.38
0.39
0.62
0.61
88 (0.150)
85 (0.155)
274 (0.467)
255 (0.464)
225 (0.383)
209 (0.381)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)
Population   G-Allele A-Allele G/G
(frequency)
G/A
(frequency)
A/A
(frequency)
 Caucasian
rs283004626 USA AD
CTR
0.24
0.26
0.76
0.74
32 (0.051)
28 (0.051)
232 (0.371)
226 (0.410)
362 (0.578)
297 (0.539)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)
Population   A-Allele G-Allele A/A
(frequency)
A/G
(frequency)
G/G
(frequency)
 Caucasian
rs283005026 USA AD
CTR
0.18
0.21
0.82
0.79
13 (0.023)
22 (0.039)
175 (0.314)
190 (0.337)
369 (0.662)
352 (0.624)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)
Population   C-Allele T-Allele C/C
(frequency)
C/T
(frequency)
T/T
(frequency)
 Caucasian
rs283005226 USA AD
CTR
0.20
0.23
0.80
0.77
25 (0.036)
35 (0.057)
229 (0.329)
211 (0.345)
441 (0.635)
366 (0.598)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)
Population   T-Allele C-Allele T/T
(frequency)
T/C
(frequency)
C/C
(frequency)
 Caucasian
rs283005326 USA AD
CTR
0.11
0.13
0.89
0.87
8 (0.014)
10 (0.018)
103 (0.182)
122 (0.220)
455 (0.804)
422 (0.762)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)
Population   G-Allele T-Allele G/G
(frequency)
G/T
(frequency)
T/T
(frequency)
 Caucasian
rs283005426 USA AD
CTR
0.32
0.31
0.68
0.69
58 (0.095)
53 (0.095)
279 (0.456)
235 (0.420)
275 (0.449)
271 (0.485)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)
Population   A-Allele G-Allele A/A
(frequency)
A/G
(frequency)
G/G
(frequency)
 Caucasian
rs283005626 USA AD
CTR
0.11
0.13
0.89
0.87
11 (0.016)
11 (0.018)
128 (0.181)
138 (0.223)
569 (0.804)
470 (0.759)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)
Population   C-Allele T-Allele C/C
(frequency)
C/T
(frequency)
T/T
(frequency)
 Caucasian
rs283008826 USA AD
CTR
0.40
0.42
0.60
0.58
95 (0.168)
96 (0.175)
266 (0.472)
267 (0.486)
203 (0.360)
186 (0.339)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)
Population   C-Allele T-Allele C/C
(frequency)
C/T
(frequency)
T/T
(frequency)
 Caucasian
rs283010326 USA AD
CTR
0.26
0.26
0.74
0.74
38 (0.065)
36 (0.071)
228 (0.389)
194 (0.383)
320 (0.546)
276 (0.545)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)
Population   T-Allele C-Allele T/T
(frequency)
T/C
(frequency)
C/C
(frequency)
 Caucasian
rs36404826 USA AD
CTR
0.47
0.48
0.53
0.52
0 (0.000)
0 (0.000)
538 (0.944)
586 (0.959)
32 (0.056)
25 (0.041)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)
Population   C-Allele T-Allele C/C
(frequency)
C/T
(frequency)
T/T
(frequency)
 Caucasian
rs43803126 USA AD
CTR
0.14
0.16
0.86
0.84
15 (0.027)
19 (0.031)
124 (0.221)
157 (0.257)
421 (0.752)
435 (0.712)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)
Population   T-Allele C-Allele T/T
(frequency)
T/C
(frequency)
C/C
(frequency)
 Caucasian
rs44066626 USA AD
CTR
0.26
0.26
0.74
0.74
51 (0.085)
35 (0.063)
209 (0.348)
216 (0.391)
340 (0.567)
301 (0.545)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)
Population   A-Allele C-Allele A/A
(frequency)
A/C
(frequency)
C/C
(frequency)
 Caucasian
rs45401726 USA AD
CTR
0.19
0.21
0.81
0.79
18 (0.029)
25 (0.045)
200 (0.323)
183 (0.330)
402 (0.648)
346 (0.625)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)
Population   G-Allele A-Allele G/G
(frequency)
G/A
(frequency)
A/A
(frequency)
 Caucasian
rs46644826 USA AD
CTR
0.43
0.46
0.57
0.54
109 (0.193)
142 (0.231)
271 (0.479)
284 (0.463)
186 (0.329)
188 (0.306)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)
Population   G-Allele T-Allele G/G
(frequency)
G/T
(frequency)
T/T
(frequency)
 Caucasian
rs46660926 USA AD
CTR
0.12
0.14
0.88
0.86
9 (0.015)
6 (0.011)
126 (0.210)
149 (0.268)
466 (0.775)
401 (0.721)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)
Population   C-Allele T-Allele C/C
(frequency)
C/T
(frequency)
T/T
(frequency)
 Caucasian
rs481709026 USA AD
CTR
0.37
0.38
0.63
0.62
92 (0.146)
95 (0.150)
287 (0.456)
285 (0.451)
250 (0.397)
252 (0.399)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)
Population   G-Allele C-Allele G/G
(frequency)
G/C
(frequency)
C/C
(frequency)
 Caucasian
rs76247926 USA AD
CTR
0.24
0.22
0.76
0.78
28 (0.047)
28 (0.050)
230 (0.385)
186 (0.334)
340 (0.569)
343 (0.616)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)
Population   C-Allele T-Allele C/C
(frequency)
C/T
(frequency)
T/T
(frequency)
 Caucasian
rs76803926 USA AD
CTR
0.29
0.30
0.71
0.70
55 (0.091)
52 (0.093)
242 (0.401)
237 (0.423)
307 (0.508)
271 (0.484)
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