AlzGene - Polymorphism Details
Back Search Methods Disclaimer Credits
 Study: Liang, 2006
 Gene: CDC2  (CDK1; DKFZp686L20222)  Entrez Gene
 Protein: cell division cycle 2   ProteinLink
 Chromosome: 10   (View: 1  2  3  4  5  6  7  8  9  10  11  12  13  14  15  16  17  18  19  20  21  22  X  Y  MT)
 Status: Updated 3 January 2010
Meta-Analysis     Gene Overview
Total number of polymorphisms investigated by this study: 6

Case-Control Studies (by ethnic group)
  Genotypes*
Polymorphism ID#
(Link to NCBI)		 Population   G-Allele A-Allele G/G
(frequency)		 G/A
(frequency)		 A/A
(frequency)
 Caucasian
rs7919724 USA AD
CTR		 0.32
0.33		 0.68
0.67		 53 (0.104)
77 (0.111)		 224 (0.438)
309 (0.445)		 234 (0.458)
309 (0.445)
*Genotypes have been calculated from allele frequencies assuming Hardy-Weinberg equilibrium.

Case-Control Studies (by ethnic group)
  Genotypes*
Polymorphism ID#
(Link to NCBI)		 Population   T-Allele C-Allele T/T
(frequency)		 T/C
(frequency)		 C/C
(frequency)
 Caucasian
rs2448341 USA AD
CTR		 0.36
0.36		 0.64
0.64		 68 (0.131)
92 (0.131)		 240 (0.463)
325 (0.462)		 210 (0.405)
286 (0.407)
*Genotypes have been calculated from allele frequencies assuming Hardy-Weinberg equilibrium.

Case-Control Studies (by ethnic group)
  Genotypes*
Polymorphism ID#
(Link to NCBI)		 Population   A-Allele G-Allele A/A
(frequency)		 A/G
(frequency)		 G/G
(frequency)
 Caucasian
rs2448347 USA AD
CTR		 0.45
0.46		 0.55
0.54		 106 (0.204)
148 (0.211)		 257 (0.495)
348 (0.497)		 156 (0.301)
204 (0.291)
*Genotypes have been calculated from allele frequencies assuming Hardy-Weinberg equilibrium.

Case-Control Studies (by ethnic group)
  Genotypes*
Polymorphism ID#
(Link to NCBI)		 Population   del-Allele ins-Allele del/del
(frequency)		 del/ins
(frequency)		 ins/ins
(frequency)
 Caucasian
rs3212319 (Ex6 7ins/del) USA AD
CTR		 0.30
0.32		 0.70
0.68		 49 (0.090)
80 (0.101)		 229 (0.419)
342 (0.433)		 269 (0.492)
367 (0.465)
*Genotypes have been calculated from allele frequencies assuming Hardy-Weinberg equilibrium.

Case-Control Studies (by ethnic group)
  Genotypes*
Polymorphism ID#
(Link to NCBI)		 Population   A-Allele G-Allele A/A
(frequency)		 A/G
(frequency)		 G/G
(frequency)
 Caucasian
rs2456777 (Ex7-15G/A) USA AD
CTR		 0.24
0.22		 0.76
0.78		 30 (0.057)
34 (0.048)		 190 (0.362)
241 (0.340)		 305 (0.581)
433 (0.612)
*Genotypes have been calculated from allele frequencies assuming Hardy-Weinberg equilibrium.

Case-Control Studies (by ethnic group)
  Genotypes*
Polymorphism ID#
(Link to NCBI)		 Population   A-Allele T-Allele A/A
(frequency)		 A/T
(frequency)		 T/T
(frequency)
 Caucasian
rs2456778 (Ex7-14T/A) USA AD
CTR		 0.23
0.22		 0.77
0.78		 29 (0.055)
33 (0.047)		 188 (0.358)
239 (0.338)		 308 (0.587)
435 (0.615)
*Genotypes have been calculated from allele frequencies assuming Hardy-Weinberg equilibrium.

Family-Based Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   G-Allele A-Allele G/G
(frequency)		 G/A
(frequency)		 A/A
(frequency)
 Caucasian
rs7919724 USA (NIMH, NCRAD, CAP) AD
CTR		 -
-		 -
-		 0 (-)
0 (-)		 0 (-)
0 (-)		 0 (-)
0 (-)
(-) :  Either no data provided, or data otherwise not eligible for inclusion (see methods for details).

Family-Based Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   T-Allele C-Allele T/T
(frequency)		 T/C
(frequency)		 C/C
(frequency)
 Caucasian
rs2448341 USA (NIMH, NCRAD, CAP) AD
CTR		 -
-		 -
-		 0 (-)
0 (-)		 0 (-)
0 (-)		 0 (-)
0 (-)
(-) :  Either no data provided, or data otherwise not eligible for inclusion (see methods for details).

Family-Based Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   A-Allele G-Allele A/A
(frequency)		 A/G
(frequency)		 G/G
(frequency)
 Caucasian
rs2448347 USA (NIMH, NCRAD, CAP) AD
CTR		 -
-		 -
-		 0 (-)
0 (-)		 0 (-)
0 (-)		 0 (-)
0 (-)
(-) :  Either no data provided, or data otherwise not eligible for inclusion (see methods for details).

Family-Based Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   del-Allele ins-Allele del/del
(frequency)		 del/ins
(frequency)		 ins/ins
(frequency)
 Caucasian
rs3212319 (Ex6 7ins/del) USA (NIMH, NCRAD, CAP) AD
CTR		 -
-		 -
-		 0 (-)
0 (-)		 0 (-)
0 (-)		 0 (-)
0 (-)
(-) :  Either no data provided, or data otherwise not eligible for inclusion (see methods for details).

Family-Based Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   A-Allele G-Allele A/A
(frequency)		 A/G
(frequency)		 G/G
(frequency)
 Caucasian
rs2456777 (Ex7-15G/A) USA (NIMH, NCRAD, CAP) AD
CTR		 -
-		 -
-		 0 (-)
0 (-)		 0 (-)
0 (-)		 0 (-)
0 (-)
rs2456777 (Ex7-15G/A) USA (NIMH, NCRAD, CAP) AD
CTR		 -
-		 -
-		 0 (-)
0 (-)		 0 (-)
0 (-)		 0 (-)
0 (-)
(-) :  Either no data provided, or data otherwise not eligible for inclusion (see methods for details).

Family-Based Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   A-Allele T-Allele A/A
(frequency)		 A/T
(frequency)		 T/T
(frequency)
 Caucasian
rs2456778 (Ex7-14T/A) USA (NIMH, NCRAD, CAP) AD
CTR		 -
-		 -
-		 0 (-)
0 (-)		 0 (-)
0 (-)		 0 (-)
0 (-)
(-) :  Either no data provided, or data otherwise not eligible for inclusion (see methods for details).
AlzGene Recent Updates
AlzGene Top Results
Top Results Details
1. APOE_e2/3/4
2. BIN1
3. CLU
4. ABCA7
5. CR1
6. PICALM
7. MS4A6A
8. CD33
9. MS4A4E
10. CD2AP
AlzGene Stats
Studies: 1395
Genes: 695
Polymorphisms: 2973
Meta-analyses: 320
Cure Alzheimer's Fund
Proud supporter of the AlzGene database.
Michael J. Fox Foundation
The PDGene database is supported by a grant from The Michael J. Fox Foundation in partnership with the Alzheimer Research Forum.

NCRAD
The National Cell Repository for Alzheimer Disease seeks to recruit 1,000 families with two or more living brothers or sisters who have been diagnosed with late onset Alzheimer’s disease.
ALSGene
AlzGene
MSGene
PDGene
SZGene
An up-to-date collection of all published genetic association studies.