AlzGene - Polymorphism Details
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 Study: Brown, 2007
 Gene: DLD  (E3; LAD; DLDH; GCSL; PHE3)  Entrez Gene    View on PDGene
 Protein: dihydrolipoamide dehydrogenase   ProteinLink
 Chromosome: 7   (View: 1  2  3  4  5  6  7  8  9  10  11  12  13  14  15  16  17  18  19  20  21  22  X  Y  MT)
 Status: Updated 11 February 2010
Meta-Analysis     Gene Overview
Total number of polymorphisms investigated by this study: 4

Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)
Population   T-Allele C-Allele T/T
(frequency)
T/C
(frequency)
C/C
(frequency)
 Caucasian
rs10263341 (exon 7) Italy AD
CTR
-
-
-
-
0 (-)
0 (-)
0 (-)
0 (-)
0 (-)
0 (-)
rs10263341 (exon 7) USA (NIMH, NCRAD) AD
CTR
-
-
-
-
0 (-)
0 (-)
0 (-)
0 (-)
0 (-)
0 (-)
(-) :  Either no data provided, or data otherwise not eligible for inclusion (see methods for details).

Case-Control Studies (by ethnic group)
  Genotypes*
Polymorphism ID#
(Link to NCBI)
Population   A-Allele T-Allele A/A
(frequency)
A/T
(frequency)
T/T
(frequency)
 Caucasian
rs8721 (exon 14a) USA (NIMH, NCRAD) AD
CTR
0.40
0.48
0.60
0.52
22 (0.163)
46 (0.235)
65 (0.481)
98 (0.500)
48 (0.356)
52 (0.265)
rs8721 (exon 14a) Italy AD
CTR
0.37
0.38
0.63
0.62
34 (0.140)
35 (0.142)
113 (0.467)
116 (0.470)
95 (0.393)
96 (0.389)
*Genotypes have been calculated from allele frequencies assuming Hardy-Weinberg equilibrium.

Case-Control Studies (by ethnic group)
  Genotypes*
Polymorphism ID#
(Link to NCBI)
Population   G-Allele T-Allele G/G
(frequency)
G/T
(frequency)
T/T
(frequency)
 Caucasian
rs17154615 (exon 14b) Italy AD
CTR
0.12
0.16
0.88
0.84
3 (0.012)
7 (0.028)
51 (0.211)
67 (0.271)
188 (0.777)
173 (0.700)
rs17154615 (exon 14b) USA (NIMH, NCRAD) AD
CTR
0.14
0.13
0.86
0.87
3 (0.022)
3 (0.015)
33 (0.244)
45 (0.230)
99 (0.733)
148 (0.755)
*Genotypes have been calculated from allele frequencies assuming Hardy-Weinberg equilibrium.

Case-Control Studies (by ethnic group)
  Genotypes*
Polymorphism ID#
(Link to NCBI)
Population   G-Allele A-Allele G/G
(frequency)
G/A
(frequency)
A/A
(frequency)
 Caucasian
rs4564 (exon 14c) USA (NIMH, NCRAD) AD
CTR
0.44
0.36
0.56
0.64
26 (0.193)
25 (0.127)
67 (0.496)
90 (0.457)
42 (0.311)
82 (0.416)
rs4564 (exon 14c) Italy AD
CTR
0.43
0.40
0.57
0.60
45 (0.186)
39 (0.158)
119 (0.492)
118 (0.478)
78 (0.322)
90 (0.364)
*Genotypes have been calculated from allele frequencies assuming Hardy-Weinberg equilibrium.
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Studies: 1395
Genes: 695
Polymorphisms: 2973
Meta-analyses: 320
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The PDGene database is supported by a grant from The Michael J. Fox Foundation in partnership with the Alzheimer Research Forum.

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