AlzGene

AlzGene - Polymorphism Details

Study:

Vazquez-Higuera, 2009

Gene:

DYRK1A (MNB; DYRK; HP86; MNBH; DYRK1)

Protein:

dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A (MNB/DYRK protein kinase)

Chromosome:

21 (View: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 X Y MT)

Status:

Updated 18 April 2011

Total number of polymorphisms investigated by this study: 7

Case-Control Studies (by ethnic group)
					Genotypes
Polymorphism ID# (Link to NCBI)	Population		C-Allele	T-Allele	C/C (frequency)	C/T (frequency)	T/T (frequency)
Caucasian
rs2835740	Spain	AD CTR	0.20 0.21	0.80 0.79	32 (0.052) 31 (0.044)	176 (0.288) 237 (0.335)	404 (0.660) 440 (0.621)

Case-Control Studies (by ethnic group)
					Genotypes
Polymorphism ID# (Link to NCBI)	Population		G-Allele	A-Allele	G/G (frequency)	G/A (frequency)	A/A (frequency)
Caucasian
rs1137600	Spain	AD CTR	0.31 0.33	0.69 0.67	69 (0.117) 83 (0.116)	231 (0.393) 307 (0.429)	288 (0.490) 326 (0.455)

Case-Control Studies (by ethnic group)
					Genotypes
Polymorphism ID# (Link to NCBI)	Population		G-Allele	A-Allele	G/G (frequency)	G/A (frequency)	A/A (frequency)
Caucasian
rs11701483	Spain	AD CTR	0.10 0.11	0.90 0.89	9 (0.015) 9 (0.012)	112 (0.181) 146 (0.201)	499 (0.805) 571 (0.787)

Case-Control Studies (by ethnic group)
					Genotypes
Polymorphism ID# (Link to NCBI)	Population		A-Allele	G-Allele	A/A (frequency)	A/G (frequency)	G/G (frequency)
Caucasian
rs2154545	Spain	AD CTR	0.38 0.41	0.62 0.59	95 (0.155) 128 (0.178)	271 (0.443) 329 (0.458)	246 (0.402) 261 (0.364)

Case-Control Studies (by ethnic group)
					Genotypes
Polymorphism ID# (Link to NCBI)	Population		T-Allele	C-Allele	T/T (frequency)	T/C (frequency)	C/C (frequency)
Caucasian
rs2835761	Spain	AD CTR	0.15 0.16	0.85 0.84	10 (0.016) 12 (0.017)	167 (0.273) 203 (0.282)	435 (0.711) 506 (0.702)

Case-Control Studies (by ethnic group)
					Genotypes
Polymorphism ID# (Link to NCBI)	Population		T-Allele	C-Allele	T/T (frequency)	T/C (frequency)	C/C (frequency)
Caucasian
rs2835762	Spain	AD CTR	0.11 0.12	0.89 0.88	7 (0.012) 12 (0.017)	118 (0.202) 146 (0.207)	459 (0.786) 549 (0.777)

Case-Control Studies (by ethnic group)
					Genotypes
Polymorphism ID# (Link to NCBI)	Population		C-Allele	A-Allele	C/C (frequency)	C/A (frequency)	A/A (frequency)
Caucasian
rs8132976	Spain	AD CTR	0.47 0.44	0.53 0.56	157 (0.260) 146 (0.207)	260 (0.430) 333 (0.472)	188 (0.311) 227 (0.322)

AlzGene Recent Updates

AlzGene Top Results

Top Results Details

1.	APOE_e2/3/4
2.	BIN1
3.	CLU
4.	ABCA7
5.	CR1
6.	PICALM
7.	MS4A6A
8.	CD33
9.	MS4A4E
10.	CD2AP

AlzGene Stats

Studies: 1395
Genes: 695
Polymorphisms: 2973
Meta-analyses: 320

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