AlzGene - Polymorphism Details
Back Search Methods Disclaimer Credits
 Study: Rogaeva, 2007
 Gene: SORL1  (GP250; LR11; LRP9; SorLA; SorLA-1)  Entrez Gene
 Protein: Sortilin-related receptor  (Sorting protein-related receptor containing LDLR class A repeats; SorLA; Low-density lipoprotein receptor relative with 11 ligand-binding repeats; LR11)  ProteinLink
 Chromosome: 11   (View: 1  2  3  4  5  6  7  8  9  10  11  12  13  14  15  16  17  18  19  20  21  22  X  Y  MT)
 Status: Updated 18 April 2011
Meta-Analysis     Gene Overview
Total number of polymorphisms investigated by this study: 29

Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   C-Allele T-Allele C/C
(frequency)		 C/T
(frequency)		 T/T
(frequency)
 Caucasian
rs1010159 Mixed (Northern European) AD
CTR		 0.33
0.33		 0.67
0.67		 17 (0.105)
22 (0.099)		 73 (0.451)
101 (0.455)		 72 (0.444)
99 (0.446)
rs1010159 USA (Mayo - AUT) AD
CTR		 0.36
0.32		 0.64
0.68		 56 (0.134)
53 (0.124)		 185 (0.444)
172 (0.401)		 176 (0.422)
204 (0.476)
rs1010159 USA (MCJ) AD
CTR		 0.36
0.30		 0.64
0.70		 69 (0.127)
45 (0.095)		 259 (0.475)
192 (0.405)		 217 (0.398)
237 (0.500)
rs1010159 USA (MCR) AD
CTR		 0.36
0.35		 0.64
0.65		 54 (0.128)
139 (0.115)		 196 (0.464)
573 (0.476)		 172 (0.408)
493 (0.409)
 Other/Mixed
rs1010159 Israel (Wadi Ara) AD
CTR		 0.42
0.46		 0.58
0.54		 19 (0.186)
17 (0.149)		 48 (0.471)
72 (0.632)		 35 (0.343)
25 (0.219)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   C-Allele T-Allele C/C
(frequency)		 C/T
(frequency)		 T/T
(frequency)
 Caucasian
rs11218304 Mixed (Northern European) AD
CTR		 0.46
0.38		 0.54
0.62		 31 (0.235)
28 (0.147)		 59 (0.447)
89 (0.466)		 42 (0.318)
74 (0.387)
rs11218304 USA (MCR) AD
CTR		 0.41
0.39		 0.59
0.61		 73 (0.171)
176 (0.146)		 203 (0.477)
591 (0.492)		 150 (0.352)
435 (0.362)
rs11218304 USA (MCJ) AD
CTR		 0.41
0.41		 0.59
0.59		 87 (0.159)
78 (0.164)		 276 (0.505)
238 (0.501)		 184 (0.336)
159 (0.335)
rs11218304 USA (Mayo - AUT) AD
CTR		 0.41
0.39		 0.59
0.61		 71 (0.173)
55 (0.129)		 195 (0.474)
219 (0.513)		 145 (0.353)
153 (0.358)
 Other/Mixed
rs11218304 Israel (Wadi Ara) AD
CTR		 0.43
0.28		 0.57
0.72		 18 (0.178)
10 (0.088)		 50 (0.495)
43 (0.377)		 33 (0.327)
61 (0.535)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   T-Allele A-Allele T/T
(frequency)		 T/A
(frequency)		 A/A
(frequency)
 Caucasian
rs11218340 Mixed (Northern European) AD
CTR		 0.08
0.05		 0.92
0.95		 0 (0.000)
0 (0.000)		 21 (0.156)
20 (0.100)		 114 (0.844)
180 (0.900)
 Other/Mixed
rs11218340 Israel (Wadi Ara) AD
CTR		 0.06
0.10		 0.94
0.90		 1 (0.009)
1 (0.009)		 12 (0.109)
21 (0.188)		 97 (0.882)
90 (0.804)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   G-Allele C-Allele G/G
(frequency)		 G/C
(frequency)		 C/C
(frequency)
 Caucasian
rs1131497 Mixed (Northern European) AD
CTR		 -
-		 -
-		 0 (-)
0 (-)		 0 (-)
0 (-)		 0 (-)
0 (-)
 Other/Mixed
rs1131497 Israel (Wadi Ara) AD
CTR		 -
-		 -
-		 0 (-)
0 (-)		 0 (-)
0 (-)		 0 (-)
0 (-)
(-) :  Either no data provided, or data otherwise not eligible for inclusion (see methods for details).

Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   A-Allele G-Allele A/A
(frequency)		 A/G
(frequency)		 G/G
(frequency)
 Caucasian
rs1133174 Mixed (Northern European) AD
CTR		 0.46
0.39		 0.54
0.61		 30 (0.184)
34 (0.159)		 89 (0.546)
101 (0.472)		 44 (0.270)
79 (0.369)
 Other/Mixed
rs1133174 Israel (Wadi Ara) AD
CTR		 0.42
0.56		 0.58
0.44		 17 (0.159)
35 (0.313)		 56 (0.523)
55 (0.491)		 34 (0.318)
22 (0.196)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   C-Allele T-Allele C/C
(frequency)		 C/T
(frequency)		 T/T
(frequency)
 Caucasian
rs11600231 Mixed (Northern European) AD
CTR		 0.12
0.08		 0.88
0.92		 1 (0.007)
1 (0.005)		 30 (0.221)
29 (0.153)		 105 (0.772)
160 (0.842)
 Other/Mixed
rs11600231 Israel (Wadi Ara) AD
CTR		 0.16
0.19		 0.84
0.81		 5 (0.045)
6 (0.053)		 26 (0.236)
31 (0.274)		 79 (0.718)
76 (0.673)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   T-Allele C-Allele T/T
(frequency)		 T/C
(frequency)		 C/C
(frequency)
 Caucasian
rs12285364 Mixed (Northern European) AD
CTR		 0.04
0.05		 0.96
0.95		 1 (0.006)
0 (0.000)		 11 (0.068)
22 (0.099)		 149 (0.925)
201 (0.901)
rs12285364 USA (Mayo - AUT) AD
CTR		 0.07
0.04		 0.93
0.96		 1 (0.002)
0 (0.000)		 54 (0.131)
30 (0.071)		 356 (0.866)
392 (0.929)
rs12285364 USA (MCJ) AD
CTR		 0.05
0.04		 0.95
0.96		 1 (0.002)
1 (0.002)		 49 (0.090)
37 (0.078)		 496 (0.908)
435 (0.920)
rs12285364 USA (MCR) AD
CTR		 0.05
0.05		 0.95
0.95		 1 (0.002)
2 (0.002)		 44 (0.103)
115 (0.095)		 383 (0.895)
1091 (0.903)
 Other/Mixed
rs12285364 Israel (Wadi Ara) AD
CTR		 -
-		 -
-		 0 (-)
0 (-)		 0 (-)
0 (-)		 0 (-)
0 (-)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   A-Allele G-Allele A/A
(frequency)		 A/G
(frequency)		 G/G
(frequency)
 Caucasian
rs12364988 Mixed (Northern European) AD
CTR		 0.40
0.47		 0.60
0.53		 30 (0.195)
44 (0.207)		 62 (0.403)
113 (0.531)		 62 (0.403)
56 (0.263)
 Other/Mixed
rs12364988 Israel (Wadi Ara) AD
CTR		 0.38
0.50		 0.62
0.50		 18 (0.170)
31 (0.282)		 44 (0.415)
49 (0.445)		 44 (0.415)
30 (0.273)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   A-Allele C-Allele A/A
(frequency)		 A/C
(frequency)		 C/C
(frequency)
 Caucasian
rs1614735 Mixed (Northern European) AD
CTR		 -
-		 -
-		 0 (-)
0 (-)		 0 (-)
0 (-)		 0 (-)
0 (-)
 Other/Mixed
rs1614735 Israel (Wadi Ara) AD
CTR		 -
-		 -
-		 0 (-)
0 (-)		 0 (-)
0 (-)		 0 (-)
0 (-)
(-) :  Either no data provided, or data otherwise not eligible for inclusion (see methods for details).

Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   C-Allele T-Allele C/C
(frequency)		 C/T
(frequency)		 T/T
(frequency)
 Caucasian
rs1699102 Mixed (Northern European) AD
CTR		 0.31
0.31		 0.69
0.69		 12 (0.089)
20 (0.105)		 61 (0.452)
78 (0.411)		 62 (0.459)
92 (0.484)
rs1699102 USA (MCR) AD
CTR		 0.36
0.34		 0.64
0.66		 57 (0.134)
131 (0.108)		 193 (0.453)
571 (0.473)		 176 (0.413)
506 (0.419)
rs1699102 USA (MCJ) AD
CTR		 0.34
0.30		 0.66
0.70		 56 (0.103)
37 (0.078)		 258 (0.473)
209 (0.442)		 231 (0.424)
227 (0.480)
rs1699102 USA (Mayo - AUT) AD
CTR		 0.35
0.32		 0.65
0.68		 56 (0.135)
49 (0.115)		 174 (0.420)
172 (0.405)		 184 (0.444)
204 (0.480)
 Other/Mixed
rs1699102 Israel (Wadi Ara) AD
CTR		 0.33
0.42		 0.67
0.58		 12 (0.109)
17 (0.156)		 49 (0.445)
58 (0.532)		 49 (0.445)
34 (0.312)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   G-Allele A-Allele G/G
(frequency)		 G/A
(frequency)		 A/A
(frequency)
 Caucasian
rs1784933 Mixed (Northern European) AD
CTR		 0.05
0.06		 0.95
0.94		 2 (0.013)
2 (0.009)		 12 (0.078)
20 (0.094)		 140 (0.909)
191 (0.897)
 Other/Mixed
rs1784933 Israel (Wadi Ara) AD
CTR		 0.08
0.09		 0.92
0.91		 2 (0.018)
0 (0.000)		 13 (0.118)
19 (0.173)		 95 (0.864)
91 (0.827)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   G-Allele T-Allele G/G
(frequency)		 G/T
(frequency)		 T/T
(frequency)
 Caucasian
rs2070045 Mixed (Northern European) AD
CTR		 0.35
0.23		 0.65
0.77		 27 (0.197)
15 (0.080)		 43 (0.314)
58 (0.309)		 67 (0.489)
115 (0.612)
rs2070045 USA (Mayo - AUT) AD
CTR		 0.24
0.22		 0.76
0.78		 26 (0.063)
30 (0.070)		 149 (0.359)
126 (0.294)		 240 (0.578)
272 (0.636)
rs2070045 USA (MCJ) AD
CTR		 0.23
0.21		 0.77
0.79		 30 (0.055)
21 (0.044)		 197 (0.360)
160 (0.335)		 320 (0.585)
296 (0.621)
rs2070045 USA (MCR) AD
CTR		 0.27
0.23		 0.73
0.77		 29 (0.067)
63 (0.052)		 171 (0.398)
438 (0.363)		 230 (0.535)
706 (0.585)
 Other/Mixed
rs2070045 Israel (Wadi Ara) AD
CTR		 0.22
0.25		 0.78
0.75		 6 (0.055)
5 (0.045)		 37 (0.336)
46 (0.411)		 67 (0.609)
61 (0.545)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   T-Allele G-Allele T/T
(frequency)		 T/G
(frequency)		 G/G
(frequency)
 Caucasian
rs2276346 Mixed (Northern European) AD
CTR		 0.38
0.35		 0.62
0.65		 22 (0.136)
21 (0.101)		 80 (0.494)
103 (0.498)		 60 (0.370)
83 (0.401)
 Other/Mixed
rs2276346 Israel (Wadi Ara) AD
CTR		 0.37
0.28		 0.64
0.72		 16 (0.160)
9 (0.079)		 41 (0.410)
45 (0.395)		 43 (0.430)
60 (0.526)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   T-Allele C-Allele T/T
(frequency)		 T/C
(frequency)		 C/C
(frequency)
 Caucasian
rs2282649 Mixed (Northern European) AD
CTR		 0.27
0.25		 0.73
0.75		 12 (0.074)
12 (0.054)		 63 (0.389)
88 (0.398)		 87 (0.537)
121 (0.548)
rs2282649 USA (MCR) AD
CTR		 0.31
0.30		 0.69
0.70		 47 (0.110)
102 (0.084)		 170 (0.396)
513 (0.423)		 212 (0.494)
597 (0.493)
rs2282649 USA (MCJ) AD
CTR		 0.30
0.25		 0.70
0.75		 49 (0.090)
30 (0.064)		 233 (0.427)
175 (0.372)		 264 (0.484)
266 (0.565)
rs2282649 USA (Mayo - AUT) AD
CTR		 0.29
0.27		 0.71
0.73		 44 (0.106)
41 (0.096)		 158 (0.379)
147 (0.343)		 215 (0.516)
241 (0.562)
 Other/Mixed
rs2282649 Israel (Wadi Ara) AD
CTR		 0.27
0.27		 0.73
0.73		 11 (0.101)
7 (0.062)		 37 (0.339)
46 (0.407)		 61 (0.560)
60 (0.531)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   A-Allele G-Allele A/A
(frequency)		 A/G
(frequency)		 G/G
(frequency)
 Caucasian
rs2298813 Mixed (Northern European) AD
CTR		 0.04
0.05		 0.96
0.95		 1 (0.007)
1 (0.005)		 10 (0.065)
20 (0.094)		 142 (0.928)
192 (0.901)
 Other/Mixed
rs2298813 Israel (Wadi Ara) AD
CTR		 -
-		 -
-		 0 (-)
0 (-)		 0 (-)
0 (-)		 0 (-)
0 (-)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   G-Allele C-Allele G/G
(frequency)		 G/C
(frequency)		 C/C
(frequency)
 Caucasian
rs3824966 Mixed (Northern European) AD
CTR		 -
-		 -
-		 0 (-)
0 (-)		 0 (-)
0 (-)		 0 (-)
0 (-)
 Other/Mixed
rs3824966 Israel (Wadi Ara) AD
CTR		 -
-		 -
-		 0 (-)
0 (-)		 0 (-)
0 (-)		 0 (-)
0 (-)
(-) :  Either no data provided, or data otherwise not eligible for inclusion (see methods for details).

Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   T-Allele A-Allele T/T
(frequency)		 T/A
(frequency)		 A/A
(frequency)
 Caucasian
rs3824968 Mixed (Northern European) AD
CTR		 0.17
0.09		 0.83
0.91		 2 (0.013)
1 (0.005)		 48 (0.322)
34 (0.168)		 99 (0.664)
167 (0.827)
rs3824968 USA (Mayo - AUT) AD
CTR		 0.31
0.29		 0.69
0.71		 44 (0.105)
41 (0.096)		 176 (0.419)
167 (0.390)		 200 (0.476)
220 (0.514)
rs3824968 USA (MCJ) AD
CTR		 0.32
0.27		 0.68
0.73		 51 (0.093)
35 (0.074)		 251 (0.457)
183 (0.384)		 247 (0.450)
258 (0.542)
rs3824968 USA (MCR) AD
CTR		 0.34
0.32		 0.66
0.68		 53 (0.123)
111 (0.092)		 183 (0.425)
541 (0.447)		 195 (0.452)
557 (0.461)
 Other/Mixed
rs3824968 Israel (Wadi Ara) AD
CTR		 0.33
0.35		 0.67
0.65		 13 (0.119)
12 (0.106)		 47 (0.431)
56 (0.496)		 49 (0.450)
45 (0.398)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   G-Allele A-Allele G/G
(frequency)		 G/A
(frequency)		 A/A
(frequency)
 Caucasian
rs4935774 Mixed (Northern European) AD
CTR		 0.21
0.25		 0.79
0.75		 12 (0.074)
16 (0.075)		 44 (0.270)
75 (0.350)		 107 (0.656)
123 (0.575)
 Other/Mixed
rs4935774 Israel (Wadi Ara) AD
CTR		 0.17
0.24		 0.83
0.76		 5 (0.046)
7 (0.065)		 28 (0.257)
37 (0.343)		 76 (0.697)
64 (0.593)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   C-Allele A-Allele C/C
(frequency)		 C/A
(frequency)		 A/A
(frequency)
 Caucasian
rs4935775 Mixed (Northern European) AD
CTR		 0.50
0.41		 0.50
0.59		 37 (0.268)
34 (0.177)		 63 (0.457)
90 (0.469)		 38 (0.275)
68 (0.354)
 Other/Mixed
rs4935775 Israel (Wadi Ara) AD
CTR		 0.47
0.31		 0.53
0.69		 28 (0.264)
14 (0.130)		 44 (0.415)
39 (0.361)		 34 (0.321)
55 (0.509)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   T-Allele G-Allele T/T
(frequency)		 T/G
(frequency)		 G/G
(frequency)
 Caucasian
rs556349 Mixed (Northern European) AD
CTR		 0.35
0.30		 0.65
0.70		 14 (0.101)
17 (0.089)		 68 (0.493)
81 (0.424)		 56 (0.406)
93 (0.487)
 Other/Mixed
rs556349 Israel (Wadi Ara) AD
CTR		 0.34
0.43		 0.66
0.57		 15 (0.136)
16 (0.140)		 44 (0.400)
66 (0.579)		 51 (0.464)
32 (0.281)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   A-Allele T-Allele A/A
(frequency)		 A/T
(frequency)		 T/T
(frequency)
 Caucasian
rs560573 Mixed (Northern European) AD
CTR		 -
-		 -
-		 0 (-)
0 (-)		 0 (-)
0 (-)		 0 (-)
0 (-)
 Other/Mixed
rs560573 Israel (Wadi Ara) AD
CTR		 -
-		 -
-		 0 (-)
0 (-)		 0 (-)
0 (-)		 0 (-)
0 (-)
(-) :  Either no data provided, or data otherwise not eligible for inclusion (see methods for details).

Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   C-Allele G-Allele C/C
(frequency)		 C/G
(frequency)		 G/G
(frequency)
 Caucasian
rs578506 Mixed (Northern European) AD
CTR		 -
-		 -
-		 0 (-)
0 (-)		 0 (-)
0 (-)		 0 (-)
0 (-)
 Other/Mixed
rs578506 Israel (Wadi Ara) AD
CTR		 -
-		 -
-		 0 (-)
0 (-)		 0 (-)
0 (-)		 0 (-)
0 (-)
(-) :  Either no data provided, or data otherwise not eligible for inclusion (see methods for details).

Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   G-Allele A-Allele G/G
(frequency)		 G/A
(frequency)		 A/A
(frequency)
 Caucasian
rs582446 Mixed (Northern European) AD
CTR		 0.10
0.14		 0.90
0.86		 1 (0.007)
5 (0.023)		 28 (0.183)
50 (0.235)		 124 (0.810)
158 (0.742)
 Other/Mixed
rs582446 Israel (Wadi Ara) AD
CTR		 0.20
0.19		 0.80
0.81		 5 (0.046)
5 (0.045)		 34 (0.312)
33 (0.295)		 70 (0.642)
74 (0.661)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   T-Allele C-Allele T/T
(frequency)		 T/C
(frequency)		 C/C
(frequency)
 Caucasian
rs641120 Mixed (Northern European) AD
CTR		 0.35
0.42		 0.65
0.58		 26 (0.160)
37 (0.166)		 62 (0.383)
112 (0.502)		 74 (0.457)
74 (0.332)
 Other/Mixed
rs641120 Israel (Wadi Ara) AD
CTR		 0.32
0.45		 0.68
0.55		 12 (0.112)
23 (0.202)		 44 (0.411)
56 (0.491)		 51 (0.477)
35 (0.307)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   C-Allele T-Allele C/C
(frequency)		 C/T
(frequency)		 T/T
(frequency)
 Caucasian
rs661057 Mixed (Northern European) AD
CTR		 0.34
0.40		 0.66
0.60		 24 (0.148)
31 (0.139)		 62 (0.383)
118 (0.529)		 76 (0.469)
74 (0.332)
rs661057 USA (MCR) AD
CTR		 0.45
0.46		 0.55
0.54		 81 (0.189)
237 (0.198)		 219 (0.512)
626 (0.522)		 128 (0.299)
337 (0.281)
rs661057 USA (MCJ) AD
CTR		 0.41
0.43		 0.59
0.57		 83 (0.153)
98 (0.208)		 275 (0.508)
210 (0.445)		 183 (0.338)
164 (0.347)
rs661057 USA (Mayo - AUT) AD
CTR		 0.40
0.45		 0.60
0.55		 68 (0.166)
90 (0.210)		 193 (0.472)
201 (0.470)		 148 (0.362)
137 (0.320)
 Other/Mixed
rs661057 Israel (Wadi Ara) AD
CTR		 0.27
0.41		 0.73
0.59		 7 (0.064)
17 (0.152)		 45 (0.413)
57 (0.509)		 57 (0.523)
38 (0.339)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   T-Allele C-Allele T/T
(frequency)		 T/C
(frequency)		 C/C
(frequency)
 Caucasian
rs668387 Mixed (Northern European) AD
CTR		 0.34
0.43		 0.66
0.57		 19 (0.138)
36 (0.188)		 56 (0.406)
93 (0.484)		 63 (0.457)
63 (0.328)
rs668387 USA (Mayo - AUT) AD
CTR		 0.41
0.45		 0.59
0.55		 63 (0.155)
85 (0.200)		 207 (0.509)
215 (0.506)		 137 (0.337)
125 (0.294)
rs668387 USA (MCJ) AD
CTR		 0.42
0.45		 0.58
0.55		 98 (0.179)
93 (0.195)		 260 (0.476)
240 (0.503)		 188 (0.344)
144 (0.302)
rs668387 USA (MCR) AD
CTR		 0.45
0.44		 0.55
0.56		 86 (0.201)
217 (0.181)		 210 (0.491)
620 (0.516)		 132 (0.308)
365 (0.304)
 Other/Mixed
rs668387 Israel (Wadi Ara) AD
CTR		 0.33
0.47		 0.67
0.53		 12 (0.109)
23 (0.213)		 48 (0.436)
56 (0.519)		 50 (0.455)
29 (0.269)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   A-Allele G-Allele A/A
(frequency)		 A/G
(frequency)		 G/G
(frequency)
 Caucasian
rs689021 Mixed (Northern European) AD
CTR		 0.35
0.43		 0.65
0.57		 25 (0.162)
36 (0.170)		 59 (0.383)
110 (0.519)		 70 (0.455)
66 (0.311)
rs689021 USA (MCR) AD
CTR		 0.45
0.44		 0.55
0.56		 89 (0.207)
220 (0.182)		 209 (0.486)
624 (0.517)		 132 (0.307)
363 (0.301)
rs689021 USA (MCJ) AD
CTR		 0.42
0.45		 0.58
0.55		 102 (0.186)
96 (0.202)		 260 (0.474)
237 (0.498)		 187 (0.341)
143 (0.300)
rs689021 USA (Mayo - AUT) AD
CTR		 0.44
0.46		 0.56
0.54		 77 (0.188)
89 (0.210)		 202 (0.494)
211 (0.499)		 130 (0.318)
123 (0.291)
 Other/Mixed
rs689021 Israel (Wadi Ara) AD
CTR		 0.33
0.46		 0.67
0.54		 11 (0.102)
23 (0.207)		 50 (0.463)
56 (0.505)		 47 (0.435)
32 (0.288)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   G-Allele C-Allele G/G
(frequency)		 G/C
(frequency)		 C/C
(frequency)
 Caucasian
SORL1-18ex26 Mixed (Northern European) AD
CTR		 0.06
0.12		 0.94
0.88		 2 (0.012)
3 (0.014)		 17 (0.104)
44 (0.213)		 145 (0.884)
160 (0.773)
 Other/Mixed
SORL1-18ex26 Israel (Wadi Ara) AD
CTR		 0.11
0.08		 0.89
0.92		 2 (0.018)
1 (0.009)		 20 (0.182)
15 (0.135)		 88 (0.800)
95 (0.856)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   T-Allele A-Allele T/T
(frequency)		 T/A
(frequency)		 A/A
(frequency)
 Caucasian
SORL1-T833T Mixed (Northern European) AD
CTR		 0.02
0.07		 0.98
0.93		 0 (0.000)
0 (0.000)		 8 (0.049)
31 (0.148)		 156 (0.951)
179 (0.852)
 Other/Mixed
SORL1-T833T Israel (Wadi Ara) AD
CTR		 0.06
0.04		 0.94
0.96		 0 (0.000)
1 (0.009)		 12 (0.110)
8 (0.071)		 97 (0.890)
104 (0.920)


Family-Based Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   C-Allele T-Allele C/C
(frequency)		 C/T
(frequency)		 T/T
(frequency)
 African Descent
rs1010159 USA (Mirage) AD
CTR		 -
-		 -
-		 0 (-)
0 (-)		 0 (-)
0 (-)		 0 (-)
0 (-)
 Caucasian
rs1010159 Mixed (Northern European) AD
CTR		 -
-		 -
-		 0 (-)
0 (-)		 0 (-)
0 (-)		 0 (-)
0 (-)
rs1010159 USA (Mirage) AD
CTR		 -
-		 -
-		 0 (-)
0 (-)		 0 (-)
0 (-)		 0 (-)
0 (-)
 Hispanic
rs1010159 USA, Caribbean AD
CTR		 -
-		 -
-		 0 (-)
0 (-)		 0 (-)
0 (-)		 0 (-)
0 (-)
(-) :  Either no data provided, or data otherwise not eligible for inclusion (see methods for details).

Family-Based Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   C-Allele T-Allele C/C
(frequency)		 C/T
(frequency)		 T/T
(frequency)
 African Descent
rs11218304 USA (Mirage) AD
CTR		 -
-		 -
-		 0 (-)
0 (-)		 0 (-)
0 (-)		 0 (-)
0 (-)
 Caucasian
rs11218304 USA (Mirage) AD
CTR		 -
-		 -
-		 0 (-)
0 (-)		 0 (-)
0 (-)		 0 (-)
0 (-)
rs11218304 Mixed (Northern European) AD
CTR		 -
-		 -
-		 0 (-)
0 (-)		 0 (-)
0 (-)		 0 (-)
0 (-)
 Hispanic
rs11218304 USA, Caribbean AD
CTR		 -
-		 -
-		 0 (-)
0 (-)		 0 (-)
0 (-)		 0 (-)
0 (-)
(-) :  Either no data provided, or data otherwise not eligible for inclusion (see methods for details).

Family-Based Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   T-Allele A-Allele T/T
(frequency)		 T/A
(frequency)		 A/A
(frequency)
 African Descent
rs11218340 USA (Mirage) AD
CTR		 -
-		 -
-		 0 (-)
0 (-)		 0 (-)
0 (-)		 0 (-)
0 (-)
 Caucasian
rs11218340 USA (Mirage) AD
CTR		 -
-		 -
-		 0 (-)
0 (-)		 0 (-)
0 (-)		 0 (-)
0 (-)
rs11218340 Mixed (Northern European) AD
CTR		 -
-		 -
-		 0 (-)
0 (-)		 0 (-)
0 (-)		 0 (-)
0 (-)
 Hispanic
rs11218340 USA, Caribbean AD
CTR		 -
-		 -
-		 0 (-)
0 (-)		 0 (-)
0 (-)		 0 (-)
0 (-)
(-) :  Either no data provided, or data otherwise not eligible for inclusion (see methods for details).

Family-Based Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   G-Allele C-Allele G/G
(frequency)		 G/C
(frequency)		 C/C
(frequency)
 African Descent
rs1131497 USA (Mirage) AD
CTR		 -
-		 -
-		 0 (-)
0 (-)		 0 (-)
0 (-)		 0 (-)
0 (-)
 Caucasian
rs1131497 USA (Mirage) AD
CTR		 -
-		 -
-		 0 (-)
0 (-)		 0 (-)
0 (-)		 0 (-)
0 (-)
rs1131497 Mixed (Northern European) AD
CTR		 -
-		 -
-		 0 (-)
0 (-)		 0 (-)
0 (-)		 0 (-)
0 (-)
 Hispanic
rs1131497 USA, Caribbean AD
CTR		 -
-		 -
-		 0 (-)
0 (-)		 0 (-)
0 (-)		 0 (-)
0 (-)
(-) :  Either no data provided, or data otherwise not eligible for inclusion (see methods for details).

Family-Based Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   A-Allele G-Allele A/A
(frequency)		 A/G
(frequency)		 G/G
(frequency)
 African Descent
rs1133174 USA (Mirage) AD
CTR		 -
-		 -
-		 0 (-)
0 (-)		 0 (-)
0 (-)		 0 (-)
0 (-)
 Caucasian
rs1133174 USA (Mirage) AD
CTR		 -
-		 -
-		 0 (-)
0 (-)		 0 (-)
0 (-)		 0 (-)
0 (-)
rs1133174 Mixed (Northern European) AD
CTR		 -
-		 -
-		 0 (-)
0 (-)		 0 (-)
0 (-)		 0 (-)
0 (-)
 Hispanic
rs1133174 USA, Caribbean AD
CTR		 -
-		 -
-		 0 (-)
0 (-)		 0 (-)
0 (-)		 0 (-)
0 (-)
(-) :  Either no data provided, or data otherwise not eligible for inclusion (see methods for details).

Family-Based Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   C-Allele T-Allele C/C
(frequency)		 C/T
(frequency)		 T/T
(frequency)
 African Descent
rs11600231 USA (Mirage) AD
CTR		 -
-		 -
-		 0 (-)
0 (-)		 0 (-)
0 (-)		 0 (-)
0 (-)
 Caucasian
rs11600231 USA (Mirage) AD
CTR		 -
-		 -
-		 0 (-)
0 (-)		 0 (-)
0 (-)		 0 (-)
0 (-)
rs11600231 Mixed (Northern European) AD
CTR		 -
-		 -
-		 0 (-)
0 (-)		 0 (-)
0 (-)		 0 (-)
0 (-)
 Hispanic
rs11600231 USA, Caribbean AD
CTR		 -
-		 -
-		 0 (-)
0 (-)		 0 (-)
0 (-)		 0 (-)
0 (-)
(-) :  Either no data provided, or data otherwise not eligible for inclusion (see methods for details).

Family-Based Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   T-Allele C-Allele T/T
(frequency)		 T/C
(frequency)		 C/C
(frequency)
 African Descent
rs12285364 USA (Mirage) AD
CTR		 -
-		 -
-		 0 (-)
0 (-)		 0 (-)
0 (-)		 0 (-)
0 (-)
 Caucasian
rs12285364 USA (Mirage) AD
CTR		 -
-		 -
-		 0 (-)
0 (-)		 0 (-)
0 (-)		 0 (-)
0 (-)
rs12285364 Mixed (Northern European) AD
CTR		 -
-		 -
-		 0 (-)
0 (-)		 0 (-)
0 (-)		 0 (-)
0 (-)
 Hispanic
rs12285364 USA, Caribbean AD
CTR		 -
-		 -
-		 0 (-)
0 (-)		 0 (-)
0 (-)		 0 (-)
0 (-)
(-) :  Either no data provided, or data otherwise not eligible for inclusion (see methods for details).

Family-Based Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   A-Allele G-Allele A/A
(frequency)		 A/G
(frequency)		 G/G
(frequency)
 African Descent
rs12364988 USA (Mirage) AD
CTR		 -
-		 -
-		 0 (-)
0 (-)		 0 (-)
0 (-)		 0 (-)
0 (-)
 Caucasian
rs12364988 USA (Mirage) AD
CTR		 -
-		 -
-		 0 (-)
0 (-)		 0 (-)
0 (-)		 0 (-)
0 (-)
rs12364988 Mixed (Northern European) AD
CTR		 -
-		 -
-		 0 (-)
0 (-)		 0 (-)
0 (-)		 0 (-)
0 (-)
 Hispanic
rs12364988 USA, Caribbean AD
CTR		 -
-		 -
-		 0 (-)
0 (-)		 0 (-)
0 (-)		 0 (-)
0 (-)
(-) :  Either no data provided, or data otherwise not eligible for inclusion (see methods for details).

Family-Based Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   A-Allele C-Allele A/A
(frequency)		 A/C
(frequency)		 C/C
(frequency)
 African Descent
rs1614735 USA (Mirage) AD
CTR		 -
-		 -
-		 0 (-)
0 (-)		 0 (-)
0 (-)		 0 (-)
0 (-)
 Caucasian
rs1614735 USA (Mirage) AD
CTR		 -
-		 -
-		 0 (-)
0 (-)		 0 (-)
0 (-)		 0 (-)
0 (-)
rs1614735 Mixed (Northern European) AD
CTR		 -
-		 -
-		 0 (-)
0 (-)		 0 (-)
0 (-)		 0 (-)
0 (-)
 Hispanic
rs1614735 USA, Caribbean AD
CTR		 -
-		 -
-		 0 (-)
0 (-)		 0 (-)
0 (-)		 0 (-)
0 (-)
(-) :  Either no data provided, or data otherwise not eligible for inclusion (see methods for details).

Family-Based Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   C-Allele T-Allele C/C
(frequency)		 C/T
(frequency)		 T/T
(frequency)
 African Descent
rs1699102 USA (Mirage) AD
CTR		 -
-		 -
-		 0 (-)
0 (-)		 0 (-)
0 (-)		 0 (-)
0 (-)
 Caucasian
rs1699102 USA (Mirage) AD
CTR		 -
-		 -
-		 0 (-)
0 (-)		 0 (-)
0 (-)		 0 (-)
0 (-)
rs1699102 Mixed (Northern European) AD
CTR		 -
-		 -
-		 0 (-)
0 (-)		 0 (-)
0 (-)		 0 (-)
0 (-)
 Hispanic
rs1699102 USA, Caribbean AD
CTR		 -
-		 -
-		 0 (-)
0 (-)		 0 (-)
0 (-)		 0 (-)
0 (-)
(-) :  Either no data provided, or data otherwise not eligible for inclusion (see methods for details).

Family-Based Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   G-Allele A-Allele G/G
(frequency)		 G/A
(frequency)		 A/A
(frequency)
 African Descent
rs1784933 USA (Mirage) AD
CTR		 -
-		 -
-		 0 (-)
0 (-)		 0 (-)
0 (-)		 0 (-)
0 (-)
 Caucasian
rs1784933 USA (Mirage) AD
CTR		 -
-		 -
-		 0 (-)
0 (-)		 0 (-)
0 (-)		 0 (-)
0 (-)
rs1784933 Mixed (Northern European) AD
CTR		 -
-		 -
-		 0 (-)
0 (-)		 0 (-)
0 (-)		 0 (-)
0 (-)
 Hispanic
rs1784933 USA, Caribbean AD
CTR		 -
-		 -
-		 0 (-)
0 (-)		 0 (-)
0 (-)		 0 (-)
0 (-)
(-) :  Either no data provided, or data otherwise not eligible for inclusion (see methods for details).

Family-Based Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   G-Allele T-Allele G/G
(frequency)		 G/T
(frequency)		 T/T
(frequency)
 African Descent
rs2070045 USA (Mirage) AD
CTR		 -
-		 -
-		 0 (-)
0 (-)		 0 (-)
0 (-)		 0 (-)
0 (-)
 Caucasian
rs2070045 USA (Mirage) AD
CTR		 -
-		 -
-		 0 (-)
0 (-)		 0 (-)
0 (-)		 0 (-)
0 (-)
rs2070045 Mixed (Northern European) AD
CTR		 -
-		 -
-		 0 (-)
0 (-)		 0 (-)
0 (-)		 0 (-)
0 (-)
 Hispanic
rs2070045 USA, Caribbean AD
CTR		 -
-		 -
-		 0 (-)
0 (-)		 0 (-)
0 (-)		 0 (-)
0 (-)
(-) :  Either no data provided, or data otherwise not eligible for inclusion (see methods for details).

Family-Based Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   T-Allele G-Allele T/T
(frequency)		 T/G
(frequency)		 G/G
(frequency)
 African Descent
rs2276346 USA (Mirage) AD
CTR		 -
-		 -
-		 0 (-)
0 (-)		 0 (-)
0 (-)		 0 (-)
0 (-)
 Caucasian
rs2276346 USA (Mirage) AD
CTR		 -
-		 -
-		 0 (-)
0 (-)		 0 (-)
0 (-)		 0 (-)
0 (-)
rs2276346 Mixed (Northern European) AD
CTR		 -
-		 -
-		 0 (-)
0 (-)		 0 (-)
0 (-)		 0 (-)
0 (-)
 Hispanic
rs2276346 USA, Caribbean AD
CTR		 -
-		 -
-		 0 (-)
0 (-)		 0 (-)
0 (-)		 0 (-)
0 (-)
(-) :  Either no data provided, or data otherwise not eligible for inclusion (see methods for details).

Family-Based Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   T-Allele C-Allele T/T
(frequency)		 T/C
(frequency)		 C/C
(frequency)
 African Descent
rs2282649 USA (Mirage) AD
CTR		 -
-		 -
-		 0 (-)
0 (-)		 0 (-)
0 (-)		 0 (-)
0 (-)
 Caucasian
rs2282649 USA (Mirage) AD
CTR		 -
-		 -
-		 0 (-)
0 (-)		 0 (-)
0 (-)		 0 (-)
0 (-)
rs2282649 Mixed (Northern European) AD
CTR		 -
-		 -
-		 0 (-)
0 (-)		 0 (-)
0 (-)		 0 (-)
0 (-)
 Hispanic
rs2282649 USA, Caribbean AD
CTR		 -
-		 -
-		 0 (-)
0 (-)		 0 (-)
0 (-)		 0 (-)
0 (-)
(-) :  Either no data provided, or data otherwise not eligible for inclusion (see methods for details).

Family-Based Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   A-Allele G-Allele A/A
(frequency)		 A/G
(frequency)		 G/G
(frequency)
 African Descent
rs2298813 USA (Mirage) AD
CTR		 -
-		 -
-		 0 (-)
0 (-)		 0 (-)
0 (-)		 0 (-)
0 (-)
 Caucasian
rs2298813 USA (Mirage) AD
CTR		 -
-		 -
-		 0 (-)
0 (-)		 0 (-)
0 (-)		 0 (-)
0 (-)
rs2298813 Mixed (Northern European) AD
CTR		 -
-		 -
-		 0 (-)
0 (-)		 0 (-)
0 (-)		 0 (-)
0 (-)
 Hispanic
rs2298813 USA, Caribbean AD
CTR		 -
-		 -
-		 0 (-)
0 (-)		 0 (-)
0 (-)		 0 (-)
0 (-)
(-) :  Either no data provided, or data otherwise not eligible for inclusion (see methods for details).

Family-Based Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   G-Allele C-Allele G/G
(frequency)		 G/C
(frequency)		 C/C
(frequency)
 African Descent
rs3824966 USA (Mirage) AD
CTR		 -
-		 -
-		 0 (-)
0 (-)		 0 (-)
0 (-)		 0 (-)
0 (-)
 Caucasian
rs3824966 USA (Mirage) AD
CTR		 -
-		 -
-		 0 (-)
0 (-)		 0 (-)
0 (-)		 0 (-)
0 (-)
rs3824966 Mixed (Northern European) AD
CTR		 -
-		 -
-		 0 (-)
0 (-)		 0 (-)
0 (-)		 0 (-)
0 (-)
 Hispanic
rs3824966 USA, Caribbean AD
CTR		 -
-		 -
-		 0 (-)
0 (-)		 0 (-)
0 (-)		 0 (-)
0 (-)
(-) :  Either no data provided, or data otherwise not eligible for inclusion (see methods for details).

Family-Based Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   T-Allele A-Allele T/T
(frequency)		 T/A
(frequency)		 A/A
(frequency)
 African Descent
rs3824968 USA (Mirage) AD
CTR		 -
-		 -
-		 0 (-)
0 (-)		 0 (-)
0 (-)		 0 (-)
0 (-)
 Caucasian
rs3824968 USA (Mirage) AD
CTR		 -
-		 -
-		 0 (-)
0 (-)		 0 (-)
0 (-)		 0 (-)
0 (-)
rs3824968 Mixed (Northern European) AD
CTR		 -
-		 -
-		 0 (-)
0 (-)		 0 (-)
0 (-)		 0 (-)
0 (-)
 Hispanic
rs3824968 USA, Caribbean AD
CTR		 -
-		 -
-		 0 (-)
0 (-)		 0 (-)
0 (-)		 0 (-)
0 (-)
(-) :  Either no data provided, or data otherwise not eligible for inclusion (see methods for details).

Family-Based Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   G-Allele A-Allele G/G
(frequency)		 G/A
(frequency)		 A/A
(frequency)
 African Descent
rs4935774 USA (Mirage) AD
CTR		 -
-		 -
-		 0 (-)
0 (-)		 0 (-)
0 (-)		 0 (-)
0 (-)
 Caucasian
rs4935774 USA (Mirage) AD
CTR		 -
-		 -
-		 0 (-)
0 (-)		 0 (-)
0 (-)		 0 (-)
0 (-)
rs4935774 Mixed (Northern European) AD
CTR		 -
-		 -
-		 0 (-)
0 (-)		 0 (-)
0 (-)		 0 (-)
0 (-)
 Hispanic
rs4935774 USA, Caribbean AD
CTR		 -
-		 -
-		 0 (-)
0 (-)		 0 (-)
0 (-)		 0 (-)
0 (-)
(-) :  Either no data provided, or data otherwise not eligible for inclusion (see methods for details).

Family-Based Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   C-Allele A-Allele C/C
(frequency)		 C/A
(frequency)		 A/A
(frequency)
 African Descent
rs4935775 USA (Mirage) AD
CTR		 -
-		 -
-		 0 (-)
0 (-)		 0 (-)
0 (-)		 0 (-)
0 (-)
 Caucasian
rs4935775 USA (Mirage) AD
CTR		 -
-		 -
-		 0 (-)
0 (-)		 0 (-)
0 (-)		 0 (-)
0 (-)
rs4935775 Mixed (Northern European) AD
CTR		 -
-		 -
-		 0 (-)
0 (-)		 0 (-)
0 (-)		 0 (-)
0 (-)
 Hispanic
rs4935775 USA, Caribbean AD
CTR		 -
-		 -
-		 0 (-)
0 (-)		 0 (-)
0 (-)		 0 (-)
0 (-)
(-) :  Either no data provided, or data otherwise not eligible for inclusion (see methods for details).

Family-Based Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   T-Allele G-Allele T/T
(frequency)		 T/G
(frequency)		 G/G
(frequency)
 African Descent
rs556349 USA (Mirage) AD
CTR		 -
-		 -
-		 0 (-)
0 (-)		 0 (-)
0 (-)		 0 (-)
0 (-)
 Caucasian
rs556349 USA (Mirage) AD
CTR		 -
-		 -
-		 0 (-)
0 (-)		 0 (-)
0 (-)		 0 (-)
0 (-)
rs556349 Mixed (Northern European) AD
CTR		 -
-		 -
-		 0 (-)
0 (-)		 0 (-)
0 (-)		 0 (-)
0 (-)
 Hispanic
rs556349 USA, Caribbean AD
CTR		 -
-		 -
-		 0 (-)
0 (-)		 0 (-)
0 (-)		 0 (-)
0 (-)
(-) :  Either no data provided, or data otherwise not eligible for inclusion (see methods for details).

Family-Based Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   A-Allele T-Allele A/A
(frequency)		 A/T
(frequency)		 T/T
(frequency)
 African Descent
rs560573 USA (Mirage) AD
CTR		 -
-		 -
-		 0 (-)
0 (-)		 0 (-)
0 (-)		 0 (-)
0 (-)
 Caucasian
rs560573 USA (Mirage) AD
CTR		 -
-		 -
-		 0 (-)
0 (-)		 0 (-)
0 (-)		 0 (-)
0 (-)
rs560573 Mixed (Northern European) AD
CTR		 -
-		 -
-		 0 (-)
0 (-)		 0 (-)
0 (-)		 0 (-)
0 (-)
 Hispanic
rs560573 USA, Caribbean AD
CTR		 -
-		 -
-		 0 (-)
0 (-)		 0 (-)
0 (-)		 0 (-)
0 (-)
(-) :  Either no data provided, or data otherwise not eligible for inclusion (see methods for details).

Family-Based Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   C-Allele G-Allele C/C
(frequency)		 C/G
(frequency)		 G/G
(frequency)
 African Descent
rs578506 USA (Mirage) AD
CTR		 -
-		 -
-		 0 (-)
0 (-)		 0 (-)
0 (-)		 0 (-)
0 (-)
 Caucasian
rs578506 USA (Mirage) AD
CTR		 -
-		 -
-		 0 (-)
0 (-)		 0 (-)
0 (-)		 0 (-)
0 (-)
rs578506 Mixed (Northern European) AD
CTR		 -
-		 -
-		 0 (-)
0 (-)		 0 (-)
0 (-)		 0 (-)
0 (-)
 Hispanic
rs578506 USA, Caribbean AD
CTR		 -
-		 -
-		 0 (-)
0 (-)		 0 (-)
0 (-)		 0 (-)
0 (-)
(-) :  Either no data provided, or data otherwise not eligible for inclusion (see methods for details).

Family-Based Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   G-Allele A-Allele G/G
(frequency)		 G/A
(frequency)		 A/A
(frequency)
 African Descent
rs582446 USA (Mirage) AD
CTR		 -
-		 -
-		 0 (-)
0 (-)		 0 (-)
0 (-)		 0 (-)
0 (-)
 Caucasian
rs582446 USA (Mirage) AD
CTR		 -
-		 -
-		 0 (-)
0 (-)		 0 (-)
0 (-)		 0 (-)
0 (-)
rs582446 Mixed (Northern European) AD
CTR		 -
-		 -
-		 0 (-)
0 (-)		 0 (-)
0 (-)		 0 (-)
0 (-)
 Hispanic
rs582446 USA, Caribbean AD
CTR		 -
-		 -
-		 0 (-)
0 (-)		 0 (-)
0 (-)		 0 (-)
0 (-)
(-) :  Either no data provided, or data otherwise not eligible for inclusion (see methods for details).

Family-Based Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   T-Allele C-Allele T/T
(frequency)		 T/C
(frequency)		 C/C
(frequency)
 African Descent
rs641120 USA (Mirage) AD
CTR		 -
-		 -
-		 0 (-)
0 (-)		 0 (-)
0 (-)		 0 (-)
0 (-)
 Caucasian
rs641120 USA (Mirage) AD
CTR		 -
-		 -
-		 0 (-)
0 (-)		 0 (-)
0 (-)		 0 (-)
0 (-)
rs641120 Mixed (Northern European) AD
CTR		 -
-		 -
-		 0 (-)
0 (-)		 0 (-)
0 (-)		 0 (-)
0 (-)
 Hispanic
rs641120 USA, Caribbean AD
CTR		 -
-		 -
-		 0 (-)
0 (-)		 0 (-)
0 (-)		 0 (-)
0 (-)
(-) :  Either no data provided, or data otherwise not eligible for inclusion (see methods for details).

Family-Based Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   C-Allele T-Allele C/C
(frequency)		 C/T
(frequency)		 T/T
(frequency)
 African Descent
rs661057 USA (Mirage) AD
CTR		 -
-		 -
-		 0 (-)
0 (-)		 0 (-)
0 (-)		 0 (-)
0 (-)
 Caucasian
rs661057 USA (Mirage) AD
CTR		 -
-		 -
-		 0 (-)
0 (-)		 0 (-)
0 (-)		 0 (-)
0 (-)
rs661057 Mixed (Northern European) AD
CTR		 -
-		 -
-		 0 (-)
0 (-)		 0 (-)
0 (-)		 0 (-)
0 (-)
 Hispanic
rs661057 USA, Caribbean AD
CTR		 -
-		 -
-		 0 (-)
0 (-)		 0 (-)
0 (-)		 0 (-)
0 (-)
(-) :  Either no data provided, or data otherwise not eligible for inclusion (see methods for details).

Family-Based Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   T-Allele C-Allele T/T
(frequency)		 T/C
(frequency)		 C/C
(frequency)
 African Descent
rs668387 USA (Mirage) AD
CTR		 -
-		 -
-		 0 (-)
0 (-)		 0 (-)
0 (-)		 0 (-)
0 (-)
 Caucasian
rs668387 USA (Mirage) AD
CTR		 -
-		 -
-		 0 (-)
0 (-)		 0 (-)
0 (-)		 0 (-)
0 (-)
rs668387 Mixed (Northern European) AD
CTR		 -
-		 -
-		 0 (-)
0 (-)		 0 (-)
0 (-)		 0 (-)
0 (-)
 Hispanic
rs668387 USA, Caribbean AD
CTR		 -
-		 -
-		 0 (-)
0 (-)		 0 (-)
0 (-)		 0 (-)
0 (-)
(-) :  Either no data provided, or data otherwise not eligible for inclusion (see methods for details).

Family-Based Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   A-Allele G-Allele A/A
(frequency)		 A/G
(frequency)		 G/G
(frequency)
 African Descent
rs689021 USA (Mirage) AD
CTR		 -
-		 -
-		 0 (-)
0 (-)		 0 (-)
0 (-)		 0 (-)
0 (-)
 Caucasian
rs689021 USA (Mirage) AD
CTR		 -
-		 -
-		 0 (-)
0 (-)		 0 (-)
0 (-)		 0 (-)
0 (-)
rs689021 Mixed (Northern European) AD
CTR		 -
-		 -
-		 0 (-)
0 (-)		 0 (-)
0 (-)		 0 (-)
0 (-)
 Hispanic
rs689021 USA, Caribbean AD
CTR		 -
-		 -
-		 0 (-)
0 (-)		 0 (-)
0 (-)		 0 (-)
0 (-)
(-) :  Either no data provided, or data otherwise not eligible for inclusion (see methods for details).

Family-Based Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   G-Allele C-Allele G/G
(frequency)		 G/C
(frequency)		 C/C
(frequency)
 African Descent
SORL1-18ex26 USA (Mirage) AD
CTR		 -
-		 -
-		 0 (-)
0 (-)		 0 (-)
0 (-)		 0 (-)
0 (-)
 Caucasian
SORL1-18ex26 USA (Mirage) AD
CTR		 -
-		 -
-		 0 (-)
0 (-)		 0 (-)
0 (-)		 0 (-)
0 (-)
SORL1-18ex26 Mixed (Northern European) AD
CTR		 -
-		 -
-		 0 (-)
0 (-)		 0 (-)
0 (-)		 0 (-)
0 (-)
 Hispanic
SORL1-18ex26 USA, Caribbean AD
CTR		 -
-		 -
-		 0 (-)
0 (-)		 0 (-)
0 (-)		 0 (-)
0 (-)
(-) :  Either no data provided, or data otherwise not eligible for inclusion (see methods for details).

Family-Based Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   T-Allele A-Allele T/T
(frequency)		 T/A
(frequency)		 A/A
(frequency)
 African Descent
SORL1-T833T USA (Mirage) AD
CTR		 -
-		 -
-		 0 (-)
0 (-)		 0 (-)
0 (-)		 0 (-)
0 (-)
 Caucasian
SORL1-T833T USA (Mirage) AD
CTR		 -
-		 -
-		 0 (-)
0 (-)		 0 (-)
0 (-)		 0 (-)
0 (-)
SORL1-T833T Mixed (Northern European) AD
CTR		 -
-		 -
-		 0 (-)
0 (-)		 0 (-)
0 (-)		 0 (-)
0 (-)
 Hispanic
SORL1-T833T USA, Caribbean AD
CTR		 -
-		 -
-		 0 (-)
0 (-)		 0 (-)
0 (-)		 0 (-)
0 (-)
(-) :  Either no data provided, or data otherwise not eligible for inclusion (see methods for details).
AlzGene Recent Updates
AlzGene Top Results
Top Results Details
1. APOE_e2/3/4
2. BIN1
3. CLU
4. ABCA7
5. CR1
6. PICALM
7. MS4A6A
8. CD33
9. MS4A4E
10. CD2AP
AlzGene Stats
Studies: 1395
Genes: 695
Polymorphisms: 2973
Meta-analyses: 320
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The PDGene database is supported by a grant from The Michael J. Fox Foundation in partnership with the Alzheimer Research Forum.

NCRAD
The National Cell Repository for Alzheimer Disease seeks to recruit 1,000 families with two or more living brothers or sisters who have been diagnosed with late onset Alzheimer’s disease.
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An up-to-date collection of all published genetic association studies.