AlzGene - Polymorphism Details
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 Study: Li, 2007
 Gene: SORL1  (GP250; LR11; LRP9; SorLA; SorLA-1)  Entrez Gene
 Protein: Sortilin-related receptor  (Sorting protein-related receptor containing LDLR class A repeats; SorLA; Low-density lipoprotein receptor relative with 11 ligand-binding repeats; LR11)  ProteinLink
 Chromosome: 11   (View: 1  2  3  4  5  6  7  8  9  10  11  12  13  14  15  16  17  18  19  20  21  22  X  Y  MT)
 Status: Updated 18 April 2011
Meta-Analysis     Gene Overview
Total number of polymorphisms investigated by this study: 12

Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)
Population   C-Allele T-Allele C/C
(frequency)
C/T
(frequency)
T/T
(frequency)
 Caucasian
rs1010159 UK1 AD
CTR
0.35
0.31
0.65
0.69
40 (0.117)
34 (0.098)
156 (0.457)
144 (0.416)
145 (0.425)
168 (0.486)
rs1010159 UK2 AD
CTR
0.34
0.34
0.66
0.66
27 (0.097)
37 (0.120)
134 (0.484)
136 (0.440)
116 (0.419)
136 (0.440)
rs1010159 USA (WashU) AD
CTR
0.36
0.36
0.64
0.64
44 (0.118)
48 (0.128)
179 (0.479)
173 (0.461)
151 (0.404)
154 (0.411)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)
Population   T-Allele C-Allele T/T
(frequency)
T/C
(frequency)
C/C
(frequency)
 Caucasian
rs12285364 UK1 AD
CTR
0.05
0.05
0.95
0.95
0 (0.000)
1 (0.003)
31 (0.091)
30 (0.087)
311 (0.909)
315 (0.910)
rs12285364 UK2 AD
CTR
0.05
0.04
0.95
0.96
1 (0.004)
0 (0.000)
26 (0.094)
26 (0.084)
251 (0.903)
285 (0.916)
rs12285364 USA (WashU) AD
CTR
0.05
0.04
0.95
0.96
2 (0.005)
2 (0.005)
36 (0.096)
29 (0.077)
338 (0.899)
344 (0.917)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)
Population   C-Allele T-Allele C/C
(frequency)
C/T
(frequency)
T/T
(frequency)
 Caucasian
rs1699102 UK1 AD
CTR
0.35
0.33
0.65
0.67
45 (0.132)
38 (0.110)
149 (0.436)
149 (0.431)
148 (0.433)
159 (0.460)
rs1699102 UK2 AD
CTR
0.32
0.32
0.68
0.68
22 (0.079)
33 (0.106)
134 (0.482)
134 (0.431)
122 (0.439)
144 (0.463)
rs1699102 USA (WashU) AD
CTR
0.36
0.32
0.64
0.68
46 (0.123)
40 (0.107)
174 (0.465)
158 (0.421)
154 (0.412)
177 (0.472)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)
Population   G-Allele T-Allele G/G
(frequency)
G/T
(frequency)
T/T
(frequency)
 Caucasian
rs2070045 UK1 AD
CTR
0.26
0.21
0.74
0.79
25 (0.073)
16 (0.046)
129 (0.377)
116 (0.335)
188 (0.550)
214 (0.618)
rs2070045 UK2 AD
CTR
0.24
0.23
0.76
0.77
11 (0.040)
17 (0.055)
110 (0.397)
110 (0.354)
156 (0.563)
184 (0.592)
rs2070045 USA (WashU) AD
CTR
0.25
0.23
0.75
0.77
22 (0.059)
18 (0.049)
144 (0.387)
131 (0.354)
206 (0.554)
221 (0.597)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)
Population   T-Allele C-Allele T/T
(frequency)
T/C
(frequency)
C/C
(frequency)
 Caucasian
rs2282649 UK1 AD
CTR
0.32
0.26
0.68
0.74
35 (0.103)
26 (0.075)
146 (0.428)
128 (0.371)
160 (0.469)
191 (0.554)
rs2282649 UK2 AD
CTR
0.28
0.29
0.72
0.71
20 (0.072)
27 (0.087)
113 (0.408)
124 (0.399)
144 (0.520)
160 (0.514)
rs2282649 USA (WashU) AD
CTR
0.30
0.29
0.70
0.71
34 (0.091)
28 (0.076)
157 (0.420)
155 (0.421)
183 (0.489)
185 (0.503)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)
Population   T-Allele A-Allele T/T
(frequency)
T/A
(frequency)
A/A
(frequency)
 Caucasian
rs3824968 UK1 AD
CTR
0.33
0.28
0.67
0.72
36 (0.105)
32 (0.092)
155 (0.453)
133 (0.384)
151 (0.442)
181 (0.523)
rs3824968 UK2 AD
CTR
0.29
0.31
0.71
0.69
20 (0.073)
31 (0.100)
120 (0.436)
129 (0.416)
135 (0.491)
150 (0.484)
rs3824968 USA (WashU) AD
CTR
0.31
0.31
0.69
0.69
33 (0.088)
34 (0.091)
163 (0.437)
160 (0.429)
177 (0.475)
179 (0.480)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)
Population   C-Allele A-Allele C/C
(frequency)
C/A
(frequency)
A/A
(frequency)
 Caucasian
rs4935775 UK1 AD
CTR
0.42
0.43
0.58
0.57
54 (0.158)
68 (0.197)
180 (0.528)
161 (0.465)
107 (0.314)
117 (0.338)
rs4935775 UK2 AD
CTR
0.42
0.42
0.58
0.58
53 (0.191)
60 (0.194)
130 (0.468)
142 (0.458)
95 (0.342)
108 (0.348)
rs4935775 USA (WashU) AD
CTR
0.41
0.43
0.59
0.57
66 (0.176)
69 (0.184)
174 (0.463)
182 (0.484)
136 (0.362)
125 (0.332)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)
Population   T-Allele G-Allele T/T
(frequency)
T/G
(frequency)
G/G
(frequency)
 Caucasian
rs556349 UK1 AD
CTR
0.33
0.31
0.67
0.69
39 (0.114)
35 (0.101)
150 (0.439)
144 (0.417)
153 (0.447)
166 (0.481)
rs556349 UK2 AD
CTR
0.30
0.30
0.70
0.70
18 (0.065)
28 (0.090)
129 (0.464)
130 (0.419)
131 (0.471)
152 (0.490)
rs556349 USA (WashU) AD
CTR
0.34
0.32
0.66
0.68
40 (0.108)
36 (0.097)
175 (0.470)
168 (0.450)
157 (0.422)
169 (0.453)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)
Population   T-Allele C-Allele T/T
(frequency)
T/C
(frequency)
C/C
(frequency)
 Caucasian
rs641120 UK1 AD
CTR
0.46
0.45
0.54
0.55
72 (0.211)
67 (0.194)
170 (0.499)
178 (0.516)
99 (0.290)
100 (0.290)
rs641120 UK2 AD
CTR
0.42
0.47
0.58
0.53
52 (0.187)
70 (0.225)
131 (0.471)
150 (0.482)
95 (0.342)
91 (0.293)
rs641120 USA (WashU) AD
CTR
0.43
0.43
0.57
0.57
72 (0.191)
61 (0.162)
182 (0.484)
199 (0.529)
122 (0.324)
116 (0.309)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)
Population   C-Allele T-Allele C/C
(frequency)
C/T
(frequency)
T/T
(frequency)
 Caucasian
rs661057 UK1 AD
CTR
0.46
0.46
0.54
0.54
76 (0.222)
71 (0.205)
166 (0.484)
178 (0.514)
101 (0.294)
97 (0.280)
rs661057 UK2 AD
CTR
0.42
0.46
0.58
0.54
50 (0.180)
62 (0.199)
136 (0.489)
160 (0.514)
92 (0.331)
89 (0.286)
rs661057 USA (WashU) AD
CTR
0.45
0.41
0.55
0.59
75 (0.201)
58 (0.155)
185 (0.496)
195 (0.520)
113 (0.303)
122 (0.325)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)
Population   T-Allele C-Allele T/T
(frequency)
T/C
(frequency)
C/C
(frequency)
 Caucasian
rs668387 UK1 AD
CTR
0.46
0.45
0.54
0.55
72 (0.211)
67 (0.194)
172 (0.504)
180 (0.520)
97 (0.284)
99 (0.286)
rs668387 UK2 AD
CTR
0.42
0.46
0.58
0.54
52 (0.188)
69 (0.223)
130 (0.469)
150 (0.484)
95 (0.343)
91 (0.294)
rs668387 USA (WashU) AD
CTR
0.43
0.43
0.57
0.57
71 (0.190)
61 (0.164)
182 (0.487)
194 (0.523)
121 (0.324)
116 (0.313)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)
Population   A-Allele G-Allele A/A
(frequency)
A/G
(frequency)
G/G
(frequency)
 Caucasian
rs689021 UK1 AD
CTR
0.47
0.46
0.53
0.54
74 (0.216)
69 (0.199)
174 (0.507)
178 (0.514)
95 (0.277)
99 (0.286)
rs689021 UK2 AD
CTR
0.42
0.47
0.58
0.53
52 (0.187)
71 (0.229)
131 (0.471)
150 (0.484)
95 (0.342)
89 (0.287)
rs689021 USA (WashU) AD
CTR
0.43
0.43
0.57
0.57
71 (0.189)
64 (0.172)
184 (0.489)
194 (0.520)
121 (0.322)
115 (0.308)
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Polymorphisms: 2973
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