AlzGene

AlzGene - Polymorphism Details

Study:

Carrasquillo, 2009

Gene:

TOMM40 (TOM40; PEREC1; C19orf1; PER-EC1; D19S1177E)

View on MSGene

Protein:

translocase of outer mitochondrial membrane 40 homolog (yeast)

Chromosome:

19 (View: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 X Y MT)

Status:

Updated 18 April 2011

Total number of polymorphisms investigated by this study: 3

Case-Control Studies (by ethnic group)
					Genotypes*
Polymorphism ID# (Link to NCBI)	Population		G-Allele	A-Allele	G/G (frequency)	G/A (frequency)	A/A (frequency)
Caucasian
rs157580	GWAS (Stage II)	AD CTR	0.27 0.39	0.73 0.61	113 (0.073) 184 (0.152)	610 (0.394) 575 (0.476)	824 (0.533) 450 (0.372)
rs157580	GWAS (Stage I)	AD CTR	0.25 0.40	0.75 0.60	53 (0.063) 201 (0.160)	317 (0.375) 602 (0.480)	475 (0.562) 452 (0.360)

*Genotypes have been calculated from allele frequencies assuming Hardy-Weinberg equilibrium.

Case-Control Studies (by ethnic group)
					Genotypes*
Polymorphism ID# (Link to NCBI)	Population		G-Allele	A-Allele	G/G (frequency)	G/A (frequency)	A/A (frequency)
Caucasian
rs8106922	GWAS (Stage I)	AD CTR	0.29 0.38	0.71 0.62	71 (0.084) 181 (0.144)	348 (0.412) 591 (0.471)	425 (0.504) 482 (0.384)
rs8106922	GWAS (Stage II)	AD CTR	0.30 0.42	0.70 0.58	139 (0.090) 213 (0.176)	650 (0.420) 589 (0.487)	758 (0.490) 407 (0.337)

*Genotypes have been calculated from allele frequencies assuming Hardy-Weinberg equilibrium.

Case-Control Studies (by ethnic group)
					Genotypes*
Polymorphism ID# (Link to NCBI)	Population		G-Allele	A-Allele	G/G (frequency)	G/A (frequency)	A/A (frequency)
Caucasian
rs2075650	GWAS (Stage I)	AD CTR	0.34 0.15	0.66 0.85	98 (0.116) 28 (0.022)	379 (0.449) 320 (0.255)	368 (0.436) 907 (0.723)
rs2075650	GWAS (Stage II)	AD CTR	0.32 0.11	0.68 0.89	158 (0.102) 15 (0.012)	673 (0.435) 237 (0.196)	715 (0.462) 958 (0.792)

*Genotypes have been calculated from allele frequencies assuming Hardy-Weinberg equilibrium.

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AlzGene Top Results

Top Results Details

1.	APOE_e2/3/4
2.	BIN1
3.	CLU
4.	ABCA7
5.	CR1
6.	PICALM
7.	MS4A6A
8.	CD33
9.	MS4A4E
10.	CD2AP

AlzGene Stats

Studies: 1395
Genes: 695
Polymorphisms: 2973
Meta-analyses: 320

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The PDGene database is supported by a grant from The Michael J. Fox Foundation in partnership with the Alzheimer Research Forum.

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