AlzGene - Polymorphism Details
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 Study: Wollmer, 2007
 Gene: HMGCS2   Entrez Gene
 Protein: 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2 (mitochondrial)   ProteinLink
 Chromosome: 1   (View: 1  2  3  4  5  6  7  8  9  10  11  12  13  14  15  16  17  18  19  20  21  22  X  Y  MT)
 Status: Updated 18 April 2011
Meta-Analysis     Gene Overview
Total number of polymorphisms investigated by this study: 5

Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)
Population   C-Allele T-Allele C/C
(frequency)
C/T
(frequency)
T/T
(frequency)
 Caucasian
rs1441008 Belgium AD
CTR
0.34
0.35
0.66
0.65
78 (0.111)
56 (0.123)
322 (0.457)
207 (0.456)
305 (0.433)
191 (0.421)
rs1441008 Germany AD
CTR
0.33
0.32
0.67
0.68
6 (0.154)
8 (0.118)
14 (0.359)
28 (0.412)
19 (0.487)
32 (0.471)
rs1441008 Greece AD
CTR
0.33
0.32
0.67
0.68
27 (0.103)
14 (0.146)
118 (0.449)
33 (0.344)
118 (0.449)
49 (0.510)
rs1441008 Poland AD
CTR
0.40
0.36
0.60
0.64
35 (0.162)
35 (0.150)
102 (0.472)
99 (0.423)
79 (0.366)
100 (0.427)
rs1441008 Sweden AD
CTR
0.36
0.39
0.64
0.61
32 (0.171)
23 (0.140)
72 (0.385)
81 (0.494)
83 (0.444)
60 (0.366)
rs1441008 Switzerland AD
CTR
0.34
0.29
0.66
0.71
14 (0.099)
22 (0.110)
68 (0.479)
72 (0.360)
60 (0.423)
106 (0.530)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)
Population   T-Allele G-Allele T/T
(frequency)
T/G
(frequency)
G/G
(frequency)
 Caucasian
rs532208 Belgium AD
CTR
0.48
0.51
0.52
0.49
159 (0.221)
116 (0.253)
369 (0.513)
235 (0.512)
191 (0.266)
108 (0.235)
rs532208 Germany AD
CTR
0.50
0.47
0.50
0.53
10 (0.256)
20 (0.274)
19 (0.487)
29 (0.397)
10 (0.256)
24 (0.329)
rs532208 Greece AD
CTR
0.53
0.55
0.47
0.45
78 (0.292)
28 (0.292)
127 (0.476)
50 (0.521)
62 (0.232)
18 (0.188)
rs532208 Poland AD
CTR
0.45
0.46
0.55
0.54
43 (0.203)
52 (0.219)
104 (0.491)
114 (0.481)
65 (0.307)
71 (0.300)
rs532208 Sweden AD
CTR
0.44
0.47
0.56
0.53
33 (0.178)
35 (0.219)
96 (0.519)
79 (0.494)
56 (0.303)
46 (0.288)
rs532208 Switzerland AD
CTR
0.44
0.50
0.56
0.50
26 (0.191)
56 (0.276)
69 (0.507)
90 (0.443)
41 (0.301)
57 (0.281)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)
Population   A-Allele C-Allele A/A
(frequency)
A/C
(frequency)
C/C
(frequency)
 Caucasian
rs608358 Switzerland AD
CTR
-
-
-
-
0 (-)
0 (-)
0 (-)
0 (-)
0 (-)
0 (-)
(-) :  Either no data provided, or data otherwise not eligible for inclusion (see methods for details).

Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)
Population   T-Allele G-Allele T/T
(frequency)
T/G
(frequency)
G/G
(frequency)
 Caucasian
rs651347 Belgium AD
CTR
0.31
0.31
0.69
0.69
72 (0.100)
47 (0.102)
301 (0.418)
191 (0.416)
347 (0.482)
221 (0.481)
rs651347 Germany AD
CTR
0.26
0.30
0.74
0.70
6 (0.150)
10 (0.132)
9 (0.225)
25 (0.329)
25 (0.625)
41 (0.539)
rs651347 Greece AD
CTR
0.22
0.25
0.78
0.75
11 (0.041)
4 (0.042)
97 (0.359)
40 (0.417)
162 (0.600)
52 (0.542)
rs651347 Poland AD
CTR
0.33
0.30
0.67
0.70
23 (0.107)
27 (0.114)
98 (0.456)
90 (0.380)
94 (0.437)
120 (0.506)
rs651347 Sweden AD
CTR
0.36
0.37
0.64
0.63
22 (0.123)
19 (0.119)
86 (0.480)
80 (0.503)
71 (0.397)
60 (0.377)
rs651347 Switzerland AD
CTR
0.30
0.25
0.70
0.75
14 (0.099)
16 (0.078)
56 (0.394)
69 (0.335)
72 (0.507)
121 (0.587)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)
Population   A-Allele G-Allele A/A
(frequency)
A/G
(frequency)
G/G
(frequency)
 Caucasian
rs668156 Belgium AD
CTR
0.19
0.18
0.81
0.82
24 (0.033)
14 (0.031)
219 (0.305)
139 (0.305)
476 (0.662)
302 (0.664)
rs668156 Germany AD
CTR
0.09
0.12
0.91
0.88
1 (0.025)
0 (0.000)
5 (0.125)
17 (0.239)
34 (0.850)
54 (0.761)
rs668156 Greece AD
CTR
0.18
0.22
0.82
0.78
11 (0.042)
7 (0.071)
72 (0.274)
30 (0.306)
180 (0.684)
61 (0.622)
rs668156 Poland AD
CTR
0.15
0.14
0.85
0.86
5 (0.024)
4 (0.017)
54 (0.255)
59 (0.252)
153 (0.722)
171 (0.731)
rs668156 Sweden AD
CTR
0.11
0.14
0.89
0.86
3 (0.017)
2 (0.013)
34 (0.195)
41 (0.256)
137 (0.787)
117 (0.731)
rs668156 Switzerland AD
CTR
0.16
0.19
0.84
0.81
4 (0.029)
6 (0.031)
37 (0.266)
63 (0.325)
98 (0.705)
125 (0.644)
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Studies: 1395
Genes: 695
Polymorphisms: 2973
Meta-analyses: 320
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