AlzGene - Polymorphism Details
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 Study: Todd, 2008
 Gene: BACE1  (BACE; ASP2; HSPC104; KIAA1149)  Entrez Gene
 Protein: beta-site APP-cleaving enzyme 1  (beta-secretase; APP beta-secretase; memapsin-2; aspartyl protease 2; transmembrane aspartic proteinase Asp2; membrane-associated aspartic protease 2; beta-site amyloid precursor protein cleaving enzyme)  ProteinLink
 Chromosome: 11   (View: 1  2  3  4  5  6  7  8  9  10  11  12  13  14  15  16  17  18  19  20  21  22  X  Y  MT)
 Status: Updated 18 April 2011
Meta-Analysis     Gene Overview
Total number of polymorphisms investigated by this study: 10

Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)
Population   G-Allele C-Allele G/G
(frequency)
G/C
(frequency)
C/C
(frequency)
 Caucasian
rs638405 (exon 5) Ireland AD
CTR
0.39
0.39
0.61
0.61
82 (0.178)
68 (0.163)
194 (0.421)
187 (0.450)
185 (0.401)
161 (0.387)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)
Population   A-Allele T-Allele A/A
(frequency)
A/T
(frequency)
T/T
(frequency)
 Caucasian
rs535860 Ireland AD
CTR
0.11
0.12
0.89
0.88
6 (0.012)
11 (0.026)
98 (0.204)
77 (0.184)
377 (0.784)
330 (0.789)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)
Population   G-Allele C-Allele G/G
(frequency)
G/C
(frequency)
C/C
(frequency)
 Caucasian
rs1047964 Ireland AD
CTR
0.04
0.05
0.96
0.95
1 (0.002)
2 (0.005)
37 (0.077)
37 (0.088)
444 (0.921)
380 (0.907)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)
Population   G-Allele A-Allele G/G
(frequency)
G/A
(frequency)
A/A
(frequency)
 Caucasian
rs656083 Ireland AD
CTR
0.35
0.39
0.65
0.61
72 (0.157)
67 (0.163)
179 (0.390)
187 (0.454)
208 (0.453)
158 (0.383)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)
Population   A-Allele G-Allele A/A
(frequency)
A/G
(frequency)
G/G
(frequency)
 Caucasian
rs676134 Ireland AD
CTR
0.42
0.42
0.58
0.58
98 (0.203)
77 (0.184)
205 (0.425)
194 (0.463)
179 (0.371)
148 (0.353)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)
Population   C-Allele A-Allele C/C
(frequency)
C/A
(frequency)
A/A
(frequency)
 Caucasian
rs505045 Ireland AD
CTR
0.41
0.45
0.59
0.55
83 (0.173)
85 (0.203)
225 (0.469)
205 (0.490)
172 (0.358)
128 (0.306)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)
Population   G-Allele A-Allele G/G
(frequency)
G/A
(frequency)
A/A
(frequency)
 Caucasian
rs551662 Ireland AD
CTR
0.09
0.10
0.91
0.90
6 (0.012)
2 (0.005)
77 (0.159)
77 (0.184)
400 (0.828)
340 (0.811)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)
Population   G-Allele A-Allele G/G
(frequency)
G/A
(frequency)
A/A
(frequency)
 Caucasian
rs522843 Ireland AD
CTR
0.35
0.34
0.65
0.66
71 (0.148)
51 (0.123)
196 (0.408)
182 (0.438)
213 (0.444)
183 (0.440)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)
Population   G-Allele T-Allele G/G
(frequency)
G/T
(frequency)
T/T
(frequency)
 Caucasian
rs525493 Ireland AD
CTR
0.44
0.44
0.56
0.56
109 (0.228)
90 (0.215)
208 (0.434)
189 (0.451)
162 (0.338)
140 (0.334)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)
Population   G-Allele A-Allele G/G
(frequency)
G/A
(frequency)
A/A
(frequency)
 Caucasian
rs477036 Ireland AD
CTR
0.46
0.47
0.54
0.53
104 (0.232)
84 (0.235)
208 (0.464)
169 (0.473)
136 (0.304)
104 (0.291)
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