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AlzGene - Polymorphism Details
Study:
Harold, 2007
Gene:
ADAM12
(MCMP; MLTN; MLTNA; MCMPMltna)
View on SZGene
Protein:
ADAM metallopeptidase domain 12
(meltrin alpha; a disintegrin and metalloproteinase domain 12)
Chromosome:
10
(View:
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
X
Y
MT
)
Status:
Updated 18 April 2011
Total number of polymorphisms investigated by this study: 54
Case-Control Studies (by ethnic group)
Genotypes*
Polymorphism ID#
(Link to NCBI)
Population
G-Allele
C-Allele
G/G
(frequency)
G/C
(frequency)
C/C
(frequency)
Caucasian
rs10751538
UK
AD
CTR
0.25
0.31
0.75
0.69
11 (0.059)
18 (0.097)
70 (0.376)
80 (0.430)
105 (0.565)
88 (0.473)
*Genotypes have been calculated from allele frequencies assuming Hardy-Weinberg equilibrium.
Case-Control Studies (by ethnic group)
Genotypes
Polymorphism ID#
(Link to NCBI)
Population
A-Allele
G-Allele
A/A
(frequency)
A/G
(frequency)
G/G
(frequency)
Caucasian
rs7916918
UK
AD
CTR
0.30
0.32
0.70
0.68
76 (0.078)
115 (0.097)
434 (0.446)
523 (0.439)
464 (0.476)
553 (0.464)
Case-Control Studies (by ethnic group)
Genotypes*
Polymorphism ID#
(Link to NCBI)
Population
A-Allele
G-Allele
A/A
(frequency)
A/G
(frequency)
G/G
(frequency)
Caucasian
rs7913591
UK
AD
CTR
0.26
0.36
0.74
0.64
12 (0.065)
24 (0.129)
72 (0.387)
86 (0.462)
102 (0.548)
76 (0.409)
*Genotypes have been calculated from allele frequencies assuming Hardy-Weinberg equilibrium.
Case-Control Studies (by ethnic group)
Genotypes*
Polymorphism ID#
(Link to NCBI)
Population
T-Allele
C-Allele
T/T
(frequency)
T/C
(frequency)
C/C
(frequency)
Caucasian
rs3781001
UK
AD
CTR
0.26
0.22
0.74
0.78
12 (0.065)
9 (0.048)
72 (0.387)
64 (0.344)
102 (0.548)
113 (0.608)
*Genotypes have been calculated from allele frequencies assuming Hardy-Weinberg equilibrium.
Case-Control Studies (by ethnic group)
Genotypes*
Polymorphism ID#
(Link to NCBI)
Population
C-Allele
T-Allele
C/C
(frequency)
C/T
(frequency)
T/T
(frequency)
Caucasian
rs872328
UK
AD
CTR
0.45
0.55
0.55
0.45
38 (0.204)
56 (0.301)
92 (0.495)
92 (0.495)
56 (0.301)
38 (0.204)
*Genotypes have been calculated from allele frequencies assuming Hardy-Weinberg equilibrium.
Case-Control Studies (by ethnic group)
Genotypes*
Polymorphism ID#
(Link to NCBI)
Population
G-Allele
A-Allele
G/G
(frequency)
G/A
(frequency)
A/A
(frequency)
Caucasian
rs3781002
UK
AD
CTR
0.26
0.22
0.74
0.78
12 (0.065)
9 (0.048)
72 (0.387)
64 (0.344)
102 (0.548)
113 (0.608)
*Genotypes have been calculated from allele frequencies assuming Hardy-Weinberg equilibrium.
Case-Control Studies (by ethnic group)
Genotypes*
Polymorphism ID#
(Link to NCBI)
Population
T-Allele
A-Allele
T/T
(frequency)
T/A
(frequency)
A/A
(frequency)
Caucasian
rs4732
UK
AD
CTR
0.06
0.07
0.94
0.93
1 (0.005)
1 (0.005)
21 (0.113)
24 (0.129)
164 (0.882)
161 (0.866)
*Genotypes have been calculated from allele frequencies assuming Hardy-Weinberg equilibrium.
Case-Control Studies (by ethnic group)
Genotypes*
Polymorphism ID#
(Link to NCBI)
Population
C-Allele
T-Allele
C/C
(frequency)
C/T
(frequency)
T/T
(frequency)
Caucasian
rs6693
UK
AD
CTR
0.43
0.43
0.57
0.57
34 (0.183)
34 (0.183)
91 (0.489)
91 (0.489)
61 (0.328)
61 (0.328)
*Genotypes have been calculated from allele frequencies assuming Hardy-Weinberg equilibrium.
Case-Control Studies (by ethnic group)
Genotypes*
Polymorphism ID#
(Link to NCBI)
Population
A-Allele
G-Allele
A/A
(frequency)
A/G
(frequency)
G/G
(frequency)
Caucasian
ADAM12_Exon 19S
UK
AD
CTR
0.05
0.04
0.95
0.96
0 (0.000)
0 (0.000)
18 (0.097)
14 (0.075)
168 (0.903)
172 (0.925)
*Genotypes have been calculated from allele frequencies assuming Hardy-Weinberg equilibrium.
Case-Control Studies (by ethnic group)
Genotypes*
Polymorphism ID#
(Link to NCBI)
Population
C-Allele
A-Allele
C/C
(frequency)
C/A
(frequency)
A/A
(frequency)
Caucasian
rs1278260
UK
AD
CTR
0.44
0.50
0.56
0.50
36 (0.194)
46 (0.247)
92 (0.495)
93 (0.500)
58 (0.312)
47 (0.253)
*Genotypes have been calculated from allele frequencies assuming Hardy-Weinberg equilibrium.
Case-Control Studies (by ethnic group)
Genotypes*
Polymorphism ID#
(Link to NCBI)
Population
C-Allele
T-Allele
C/C
(frequency)
C/T
(frequency)
T/T
(frequency)
Caucasian
rs7911793
UK
AD
CTR
0.23
0.27
0.77
0.73
10 (0.054)
14 (0.075)
66 (0.355)
73 (0.392)
110 (0.591)
99 (0.532)
*Genotypes have been calculated from allele frequencies assuming Hardy-Weinberg equilibrium.
Case-Control Studies (by ethnic group)
Genotypes*
Polymorphism ID#
(Link to NCBI)
Population
m-Allele
M-Allele
m/m
(frequency)
m/M
(frequency)
M/M
(frequency)
Caucasian
rs7922601
UK
AD
CTR
0.24
0.28
0.76
0.72
11 (0.059)
15 (0.081)
68 (0.366)
75 (0.403)
107 (0.575)
96 (0.516)
*Genotypes have been calculated from allele frequencies assuming Hardy-Weinberg equilibrium.
Case-Control Studies (by ethnic group)
Genotypes
Polymorphism ID#
(Link to NCBI)
Population
C-Allele
T-Allele
C/C
(frequency)
C/T
(frequency)
T/T
(frequency)
Caucasian
rs11244787
UK
AD
CTR
0.11
0.12
0.89
0.88
10 (0.010)
25 (0.021)
196 (0.199)
244 (0.205)
779 (0.791)
924 (0.775)
Case-Control Studies (by ethnic group)
Genotypes*
Polymorphism ID#
(Link to NCBI)
Population
A-Allele
G-Allele
A/A
(frequency)
A/G
(frequency)
G/G
(frequency)
Caucasian
rs2292692
UK
AD
CTR
0.11
0.17
0.89
0.83
2 (0.011)
5 (0.027)
37 (0.199)
53 (0.285)
147 (0.790)
128 (0.688)
*Genotypes have been calculated from allele frequencies assuming Hardy-Weinberg equilibrium.
Case-Control Studies (by ethnic group)
Genotypes
Polymorphism ID#
(Link to NCBI)
Population
A-Allele
T-Allele
A/A
(frequency)
A/T
(frequency)
T/T
(frequency)
Caucasian
rs1278265
UK
AD
CTR
-
-
-
-
0 (-)
0 (-)
0 (-)
0 (-)
0 (-)
0 (-)
(-)
: Either no data provided, or data otherwise not eligible for inclusion (
see methods for details)
.
Case-Control Studies (by ethnic group)
Genotypes*
Polymorphism ID#
(Link to NCBI)
Population
m-Allele
M-Allele
m/m
(frequency)
m/M
(frequency)
M/M
(frequency)
Caucasian
rs1278273
UK
AD
CTR
0.39
0.40
0.61
0.60
28 (0.151)
30 (0.161)
89 (0.478)
89 (0.478)
69 (0.371)
67 (0.360)
*Genotypes have been calculated from allele frequencies assuming Hardy-Weinberg equilibrium.
Case-Control Studies (by ethnic group)
Genotypes*
Polymorphism ID#
(Link to NCBI)
Population
A-Allele
G-Allele
A/A
(frequency)
A/G
(frequency)
G/G
(frequency)
Caucasian
rs1278278
UK
AD
CTR
0.17
0.23
0.83
0.77
5 (0.027)
10 (0.054)
53 (0.285)
66 (0.355)
128 (0.688)
110 (0.591)
*Genotypes have been calculated from allele frequencies assuming Hardy-Weinberg equilibrium.
Case-Control Studies (by ethnic group)
Genotypes*
Polymorphism ID#
(Link to NCBI)
Population
C-Allele
T-Allele
C/C
(frequency)
C/T
(frequency)
T/T
(frequency)
Caucasian
rs2279090
UK
AD
CTR
0.11
0.11
0.89
0.89
2 (0.011)
2 (0.011)
37 (0.199)
37 (0.199)
147 (0.790)
147 (0.790)
*Genotypes have been calculated from allele frequencies assuming Hardy-Weinberg equilibrium.
Case-Control Studies (by ethnic group)
Genotypes*
Polymorphism ID#
(Link to NCBI)
Population
T-Allele
C-Allele
T/T
(frequency)
T/C
(frequency)
C/C
(frequency)
Caucasian
rs2279091
UK
AD
CTR
0.12
0.15
0.88
0.85
3 (0.016)
4 (0.022)
39 (0.210)
48 (0.258)
144 (0.774)
134 (0.720)
*Genotypes have been calculated from allele frequencies assuming Hardy-Weinberg equilibrium.
Case-Control Studies (by ethnic group)
Genotypes
Polymorphism ID#
(Link to NCBI)
Population
T-Allele
C-Allele
T/T
(frequency)
T/C
(frequency)
C/C
(frequency)
Caucasian
rs1278279
UK
AD
CTR
0.18
0.20
0.82
0.80
24 (0.024)
51 (0.044)
314 (0.317)
369 (0.317)
652 (0.659)
744 (0.639)
Case-Control Studies (by ethnic group)
Genotypes*
Polymorphism ID#
(Link to NCBI)
Population
T-Allele
G-Allele
T/T
(frequency)
T/G
(frequency)
G/G
(frequency)
Caucasian
rs1278280
UK
AD
CTR
0.40
0.37
0.60
0.63
30 (0.161)
25 (0.134)
89 (0.478)
87 (0.468)
67 (0.360)
74 (0.398)
*Genotypes have been calculated from allele frequencies assuming Hardy-Weinberg equilibrium.
Case-Control Studies (by ethnic group)
Genotypes*
Polymorphism ID#
(Link to NCBI)
Population
C-Allele
T-Allele
C/C
(frequency)
C/T
(frequency)
T/T
(frequency)
Caucasian
rs1278281
UK
AD
CTR
0.19
0.20
0.81
0.80
7 (0.038)
7 (0.038)
57 (0.306)
60 (0.323)
122 (0.656)
119 (0.640)
*Genotypes have been calculated from allele frequencies assuming Hardy-Weinberg equilibrium.
Case-Control Studies (by ethnic group)
Genotypes*
Polymorphism ID#
(Link to NCBI)
Population
C-Allele
A-Allele
C/C
(frequency)
C/A
(frequency)
A/A
(frequency)
Caucasian
rs1466356
UK
AD
CTR
0.26
0.23
0.74
0.77
12 (0.065)
10 (0.054)
72 (0.387)
66 (0.355)
102 (0.548)
110 (0.591)
*Genotypes have been calculated from allele frequencies assuming Hardy-Weinberg equilibrium.
Case-Control Studies (by ethnic group)
Genotypes*
Polymorphism ID#
(Link to NCBI)
Population
C-Allele
A-Allele
C/C
(frequency)
C/A
(frequency)
A/A
(frequency)
Caucasian
rs1278282
UK
AD
CTR
0.25
0.26
0.75
0.74
11 (0.059)
13 (0.070)
70 (0.376)
71 (0.382)
105 (0.565)
102 (0.548)
*Genotypes have been calculated from allele frequencies assuming Hardy-Weinberg equilibrium.
Case-Control Studies (by ethnic group)
Genotypes
Polymorphism ID#
(Link to NCBI)
Population
T-Allele
C-Allele
T/T
(frequency)
T/C
(frequency)
C/C
(frequency)
Caucasian
rs1152653
UK
AD
CTR
0.42
0.44
0.58
0.56
151 (0.153)
221 (0.189)
521 (0.528)
584 (0.500)
315 (0.319)
362 (0.310)
Case-Control Studies (by ethnic group)
Genotypes*
Polymorphism ID#
(Link to NCBI)
Population
C-Allele
A-Allele
C/C
(frequency)
C/A
(frequency)
A/A
(frequency)
Caucasian
rs1152654
UK
AD
CTR
0.09
0.11
0.91
0.89
2 (0.011)
2 (0.011)
30 (0.161)
37 (0.199)
154 (0.828)
147 (0.790)
*Genotypes have been calculated from allele frequencies assuming Hardy-Weinberg equilibrium.
Case-Control Studies (by ethnic group)
Genotypes*
Polymorphism ID#
(Link to NCBI)
Population
A-Allele
G-Allele
A/A
(frequency)
A/G
(frequency)
G/G
(frequency)
Caucasian
rs1152655
UK
AD
CTR
0.41
0.37
0.59
0.63
31 (0.167)
25 (0.134)
90 (0.484)
87 (0.468)
65 (0.349)
74 (0.398)
*Genotypes have been calculated from allele frequencies assuming Hardy-Weinberg equilibrium.
Case-Control Studies (by ethnic group)
Genotypes*
Polymorphism ID#
(Link to NCBI)
Population
A-Allele
G-Allele
A/A
(frequency)
A/G
(frequency)
G/G
(frequency)
Caucasian
rs1152656
UK
AD
CTR
0.43
0.48
0.57
0.52
34 (0.183)
43 (0.231)
91 (0.489)
93 (0.500)
61 (0.328)
50 (0.269)
*Genotypes have been calculated from allele frequencies assuming Hardy-Weinberg equilibrium.
Case-Control Studies (by ethnic group)
Genotypes
Polymorphism ID#
(Link to NCBI)
Population
G-Allele
A-Allele
G/G
(frequency)
G/A
(frequency)
A/A
(frequency)
Caucasian
rs2290841
UK
AD
CTR
0.23
0.20
0.77
0.80
51 (0.052)
47 (0.040)
346 (0.351)
369 (0.318)
589 (0.597)
745 (0.642)
Case-Control Studies (by ethnic group)
Genotypes*
Polymorphism ID#
(Link to NCBI)
Population
T-Allele
C-Allele
T/T
(frequency)
T/C
(frequency)
C/C
(frequency)
Caucasian
rs12415903
UK
AD
CTR
0.41
0.46
0.59
0.54
31 (0.167)
39 (0.210)
90 (0.484)
93 (0.500)
65 (0.349)
54 (0.290)
*Genotypes have been calculated from allele frequencies assuming Hardy-Weinberg equilibrium.
Case-Control Studies (by ethnic group)
Genotypes*
Polymorphism ID#
(Link to NCBI)
Population
m-Allele
M-Allele
m/m
(frequency)
m/M
(frequency)
M/M
(frequency)
Caucasian
ADAM12_Intron11delT
UK
AD
CTR
0.27
0.17
0.73
0.83
14 (0.075)
5 (0.027)
73 (0.392)
53 (0.285)
99 (0.532)
128 (0.688)
*Genotypes have been calculated from allele frequencies assuming Hardy-Weinberg equilibrium.
Case-Control Studies (by ethnic group)
Genotypes*
Polymorphism ID#
(Link to NCBI)
Population
T-Allele
C-Allele
T/T
(frequency)
T/C
(frequency)
C/C
(frequency)
Caucasian
rs12415953
UK
AD
CTR
0.07
0.11
0.93
0.89
1 (0.005)
2 (0.011)
24 (0.129)
37 (0.199)
161 (0.866)
147 (0.790)
*Genotypes have been calculated from allele frequencies assuming Hardy-Weinberg equilibrium.
Case-Control Studies (by ethnic group)
Genotypes*
Polymorphism ID#
(Link to NCBI)
Population
A-Allele
G-Allele
A/A
(frequency)
A/G
(frequency)
G/G
(frequency)
Caucasian
rs3781013
UK
AD
CTR
0.13
0.20
0.87
0.80
3 (0.016)
7 (0.038)
42 (0.226)
60 (0.323)
141 (0.758)
119 (0.640)
*Genotypes have been calculated from allele frequencies assuming Hardy-Weinberg equilibrium.
Case-Control Studies (by ethnic group)
Genotypes
Polymorphism ID#
(Link to NCBI)
Population
A-Allele
G-Allele
A/A
(frequency)
A/G
(frequency)
G/G
(frequency)
Caucasian
ADAM12_Intron11G > A
UK
AD
CTR
0.02
0.02
0.98
0.98
0 (0.000)
1 (0.001)
36 (0.036)
39 (0.033)
954 (0.964)
1139 (0.966)
Case-Control Studies (by ethnic group)
Genotypes*
Polymorphism ID#
(Link to NCBI)
Population
m-Allele
M-Allele
m/m
(frequency)
m/M
(frequency)
M/M
(frequency)
Caucasian
rs1278341
UK
AD
CTR
0.35
0.32
0.65
0.68
23 (0.124)
19 (0.102)
84 (0.452)
81 (0.435)
79 (0.425)
86 (0.462)
*Genotypes have been calculated from allele frequencies assuming Hardy-Weinberg equilibrium.
Case-Control Studies (by ethnic group)
Genotypes*
Polymorphism ID#
(Link to NCBI)
Population
m-Allele
M-Allele
m/m
(frequency)
m/M
(frequency)
M/M
(frequency)
Caucasian
rs3781030
UK
AD
CTR
0.22
0.19
0.78
0.81
9 (0.048)
7 (0.038)
64 (0.344)
57 (0.306)
113 (0.608)
122 (0.656)
*Genotypes have been calculated from allele frequencies assuming Hardy-Weinberg equilibrium.
Case-Control Studies (by ethnic group)
Genotypes*
Polymorphism ID#
(Link to NCBI)
Population
T-Allele
C-Allele
T/T
(frequency)
T/C
(frequency)
C/C
(frequency)
Caucasian
rs3758419
UK
AD
CTR
0.30
0.26
0.70
0.74
17 (0.091)
13 (0.070)
78 (0.419)
71 (0.382)
91 (0.489)
102 (0.548)
*Genotypes have been calculated from allele frequencies assuming Hardy-Weinberg equilibrium.
Case-Control Studies (by ethnic group)
Genotypes*
Polymorphism ID#
(Link to NCBI)
Population
A-Allele
G-Allele
A/A
(frequency)
A/G
(frequency)
G/G
(frequency)
Caucasian
rs2290842
UK
AD
CTR
0.27
0.23
0.73
0.77
14 (0.075)
10 (0.054)
73 (0.392)
66 (0.355)
99 (0.532)
110 (0.591)
*Genotypes have been calculated from allele frequencies assuming Hardy-Weinberg equilibrium.
Case-Control Studies (by ethnic group)
Genotypes
Polymorphism ID#
(Link to NCBI)
Population
G-Allele
A-Allele
G/G
(frequency)
G/A
(frequency)
A/A
(frequency)
Caucasian
rs2290844
UK
AD
CTR
0.08
0.08
0.92
0.92
5 (0.005)
8 (0.007)
146 (0.147)
173 (0.145)
843 (0.848)
1013 (0.848)
Case-Control Studies (by ethnic group)
Genotypes*
Polymorphism ID#
(Link to NCBI)
Population
G-Allele
A-Allele
G/G
(frequency)
G/A
(frequency)
A/A
(frequency)
Caucasian
rs2290845
UK
AD
CTR
0.07
0.15
0.93
0.85
1 (0.005)
4 (0.022)
24 (0.129)
48 (0.258)
161 (0.866)
134 (0.720)
*Genotypes have been calculated from allele frequencies assuming Hardy-Weinberg equilibrium.
Case-Control Studies (by ethnic group)
Genotypes*
Polymorphism ID#
(Link to NCBI)
Population
A-Allele
C-Allele
A/A
(frequency)
A/C
(frequency)
C/C
(frequency)
Caucasian
rs1037804
UK
AD
CTR
0.11
0.11
0.89
0.89
2 (0.011)
2 (0.011)
37 (0.199)
37 (0.199)
147 (0.790)
147 (0.790)
*Genotypes have been calculated from allele frequencies assuming Hardy-Weinberg equilibrium.
Case-Control Studies (by ethnic group)
Genotypes
Polymorphism ID#
(Link to NCBI)
Population
C-Allele
G-Allele
C/C
(frequency)
C/G
(frequency)
G/G
(frequency)
Caucasian
rs1278390
UK
AD
CTR
0.41
0.43
0.59
0.57
162 (0.164)
222 (0.186)
481 (0.488)
579 (0.484)
342 (0.347)
395 (0.330)
Case-Control Studies (by ethnic group)
Genotypes*
Polymorphism ID#
(Link to NCBI)
Population
T-Allele
C-Allele
T/T
(frequency)
T/C
(frequency)
C/C
(frequency)
Caucasian
rs1278305
UK
AD
CTR
0.47
0.52
0.53
0.48
41 (0.220)
50 (0.269)
93 (0.500)
93 (0.500)
52 (0.280)
43 (0.231)
*Genotypes have been calculated from allele frequencies assuming Hardy-Weinberg equilibrium.
Case-Control Studies (by ethnic group)
Genotypes*
Polymorphism ID#
(Link to NCBI)
Population
C-Allele
T-Allele
C/C
(frequency)
C/T
(frequency)
T/T
(frequency)
Caucasian
rs1278319
UK
AD
CTR
0.47
0.53
0.53
0.47
41 (0.220)
52 (0.280)
93 (0.500)
93 (0.500)
52 (0.280)
41 (0.220)
*Genotypes have been calculated from allele frequencies assuming Hardy-Weinberg equilibrium.
Case-Control Studies (by ethnic group)
Genotypes*
Polymorphism ID#
(Link to NCBI)
Population
A-Allele
G-Allele
A/A
(frequency)
A/G
(frequency)
G/G
(frequency)
Caucasian
rs1466360
UK
AD
CTR
0.39
0.37
0.61
0.63
28 (0.151)
25 (0.134)
89 (0.478)
87 (0.468)
69 (0.371)
74 (0.398)
*Genotypes have been calculated from allele frequencies assuming Hardy-Weinberg equilibrium.
Case-Control Studies (by ethnic group)
Genotypes*
Polymorphism ID#
(Link to NCBI)
Population
T-Allele
G-Allele
T/T
(frequency)
T/G
(frequency)
G/G
(frequency)
Caucasian
rs1676724
UK
AD
CTR
0.27
0.27
0.73
0.73
14 (0.075)
14 (0.075)
73 (0.392)
73 (0.392)
99 (0.532)
99 (0.532)
*Genotypes have been calculated from allele frequencies assuming Hardy-Weinberg equilibrium.
Case-Control Studies (by ethnic group)
Genotypes*
Polymorphism ID#
(Link to NCBI)
Population
G-Allele
C-Allele
G/G
(frequency)
G/C
(frequency)
C/C
(frequency)
Caucasian
rs2126744
UK
AD
CTR
0.06
0.04
0.94
0.96
1 (0.005)
0 (0.000)
21 (0.113)
14 (0.075)
164 (0.882)
172 (0.925)
*Genotypes have been calculated from allele frequencies assuming Hardy-Weinberg equilibrium.
Case-Control Studies (by ethnic group)
Genotypes*
Polymorphism ID#
(Link to NCBI)
Population
C-Allele
T-Allele
C/C
(frequency)
C/T
(frequency)
T/T
(frequency)
Caucasian
rs1106955
UK
AD
CTR
0.19
0.23
0.81
0.77
7 (0.038)
10 (0.054)
57 (0.306)
66 (0.355)
122 (0.656)
110 (0.591)
*Genotypes have been calculated from allele frequencies assuming Hardy-Weinberg equilibrium.
Case-Control Studies (by ethnic group)
Genotypes*
Polymorphism ID#
(Link to NCBI)
Population
A-Allele
T-Allele
A/A
(frequency)
A/T
(frequency)
T/T
(frequency)
Caucasian
rs1011835
UK
AD
CTR
0.05
0.04
0.95
0.96
1 (0.005)
0 (0.000)
18 (0.097)
14 (0.075)
167 (0.898)
172 (0.925)
*Genotypes have been calculated from allele frequencies assuming Hardy-Weinberg equilibrium.
Case-Control Studies (by ethnic group)
Genotypes*
Polymorphism ID#
(Link to NCBI)
Population
C-Allele
G-Allele
C/C
(frequency)
C/G
(frequency)
G/G
(frequency)
Caucasian
rs2279755
UK
AD
CTR
0.24
0.26
0.76
0.74
11 (0.059)
13 (0.070)
68 (0.366)
71 (0.382)
107 (0.575)
102 (0.548)
*Genotypes have been calculated from allele frequencies assuming Hardy-Weinberg equilibrium.
Case-Control Studies (by ethnic group)
Genotypes*
Polymorphism ID#
(Link to NCBI)
Population
T-Allele
C-Allele
T/T
(frequency)
T/C
(frequency)
C/C
(frequency)
Caucasian
rs728104
UK
AD
CTR
0.12
0.10
0.88
0.90
3 (0.016)
2 (0.011)
39 (0.210)
33 (0.177)
144 (0.774)
151 (0.812)
*Genotypes have been calculated from allele frequencies assuming Hardy-Weinberg equilibrium.
Case-Control Studies (by ethnic group)
Genotypes*
Polymorphism ID#
(Link to NCBI)
Population
G-Allele
A-Allele
G/G
(frequency)
G/A
(frequency)
A/A
(frequency)
Caucasian
rs873957
UK
AD
CTR
0.48
0.47
0.52
0.53
43 (0.231)
41 (0.220)
93 (0.500)
93 (0.500)
50 (0.269)
52 (0.280)
*Genotypes have been calculated from allele frequencies assuming Hardy-Weinberg equilibrium.
Case-Control Studies (by ethnic group)
Genotypes*
Polymorphism ID#
(Link to NCBI)
Population
C-Allele
G-Allele
C/C
(frequency)
C/G
(frequency)
G/G
(frequency)
Caucasian
rs3740199
UK
AD
CTR
0.46
0.44
0.54
0.56
39 (0.210)
36 (0.194)
93 (0.500)
92 (0.495)
54 (0.290)
58 (0.312)
*Genotypes have been calculated from allele frequencies assuming Hardy-Weinberg equilibrium.
Case-Control Studies (by ethnic group)
Genotypes*
Polymorphism ID#
(Link to NCBI)
Population
G-Allele
A-Allele
G/G
(frequency)
G/A
(frequency)
A/A
(frequency)
Caucasian
rs2366705
UK
AD
CTR
0.26
0.31
0.74
0.69
12 (0.065)
18 (0.097)
72 (0.387)
80 (0.430)
102 (0.548)
88 (0.473)
*Genotypes have been calculated from allele frequencies assuming Hardy-Weinberg equilibrium.
AlzGene Recent Updates
APOE
PICALM
MS4A6A
MS4A4A
MS4A4E
EPHA1
CR1
CLU
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CELF2
APOC4
BCAM
CLPTM1
PVRL2
LOC3884...
TNK1
MYH13
TOMM40
PCK1
SORL1
LMNA
PGBD1
UBD
GWA_7p1...
GAB2
GOLM1
GWA_15q...
GWA_9p2...
MTHFD1L
LRAT
FAM113B
PCDH11X
GWA_14q...
ATXN1
ADAM10
CD36
DPYS
TGM4
HMMR
LAMB1
PPP3CB
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MTP18
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LIPA
CH25H
IL1RN
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MTR
FAS
CHAT
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IDE
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TF
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TCF7L2
DYRK1A
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SORCS3
F11R
TUBB
GRN
NEDD9
ARMS2
SMAD3
VCP
WWC1
DNM2
EBF3
EIF2AK2
SEC24C
SGPL1
ABCG1
LSS
ABCG4
CYP39A1
NCAPD2
GAPDHS
ACTA2
KCNMA1
MYST4
SCD
ANK3
GOT1
SORCS1
TAP2
ENTPD7
DNMBP
CXCL10
VPS26A
C12orf4...
CCNT1
DAPK1
POMT1
IREB2
HMGCR
IGF1R
ABCB1
DSC1
NQO1
HMOX1
LIPC
HMGCS1
RFTN1
APOA1BP
FDPS
HMGCS2
PRKAB2
ADAM12
DHCR24
SOS2
ABCC9
GRB14
HK1
IRS1
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PPARGC1...
PPP1CC
SLC2A2
HECTD2
PITRM1
TARDBP
CDKN2A
IGF1
CSK
CBLC
CARD8
HMOX2
TRPC4AP
GSTZ1
NUMB
POMT2
TMEM63C
THRA
TACR2
OLIG2
TTR
TNMD
EFNA5
MAGI2
CAND1
PPIL2
CDKN2BA...
PTPLA
ACAT2
CHRNB4
DGKB
GWA_10q...
GWA_18q...
GWA_3q2...
HPCAL1
EXOC3L2
GWA_3p2...
ZNF292
PATHWAY...
PATHWAY...
PATHWAY...
TP63
TMEM132...
RGS6
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NCAM2
GLOD4
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EPC2
CCDC134
ATP6V0A...
ARL5B
AGPAT1
AlzGene Top Results
Top Results Details
1.
APOE_e2/3/4
2.
BIN1
3.
CLU
4.
ABCA7
5.
CR1
6.
PICALM
7.
MS4A6A
8.
CD33
9.
MS4A4E
10.
CD2AP
AlzGene Stats
Studies: 1395
Genes: 695
Polymorphisms: 2973
Meta-analyses: 320
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The PDGene database
is supported by a grant from
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in partnership with the
Alzheimer Research Forum
.
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The National Cell Repository for Alzheimer Disease seeks to recruit 1,000 families with two or more living brothers or sisters who have been diagnosed with late onset Alzheimer’s disease.
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An up-to-date collection of all published genetic association studies.