AlzGene - Polymorphism Details
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 Study: De Ferrari, 2007
 Gene: LRP6  (ADCAD2)  Entrez Gene
 Protein: low density lipoprotein receptor-related protein 6   ProteinLink
 Chromosome: 12   (View: 1  2  3  4  5  6  7  8  9  10  11  12  13  14  15  16  17  18  19  20  21  22  X  Y  MT)
 Status: Updated 5 August 2007
Meta-Analysis     Gene Overview
Total number of polymorphisms investigated by this study: 7

Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)
Population   T-Allele C-Allele T/T
(frequency)
T/C
(frequency)
C/C
(frequency)
 Caucasian
rs1012672 (18e) Switzerland AD
CTR
0.14
0.06
0.86
0.94
1 (0.010)
1 (0.008)
24 (0.250)
13 (0.101)
71 (0.740)
115 (0.891)
rs1012672 (18e) USA AD
CTR
0.05
0.06
0.95
0.94
0 (0.000)
0 (0.000)
19 (0.109)
16 (0.127)
156 (0.891)
110 (0.873)
rs1012672 (18e) UK AD
CTR
0.10
0.05
0.90
0.95
0 (0.000)
1 (0.014)
25 (0.202)
6 (0.082)
99 (0.798)
66 (0.904)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)
Population   C-Allele T-Allele C/C
(frequency)
C/T
(frequency)
T/T
(frequency)
 Caucasian
rs2302685 (14e) Switzerland AD
CTR
0.19
0.23
0.82
0.77
1 (0.010)
6 (0.045)
35 (0.350)
49 (0.368)
64 (0.640)
78 (0.586)
rs2302685 (14e) UK AD
CTR
0.14
0.17
0.86
0.83
5 (0.039)
2 (0.029)
26 (0.205)
20 (0.286)
96 (0.756)
48 (0.686)
rs2302685 (14e) USA AD
CTR
0.14
0.15
0.86
0.85
2 (0.015)
3 (0.024)
33 (0.241)
32 (0.254)
102 (0.745)
91 (0.722)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)
Population   C-Allele T-Allele C/C
(frequency)
C/T
(frequency)
T/T
(frequency)
 Caucasian
rs7316466 Switzerland AD
CTR
0.37
0.42
0.63
0.58
10 (0.095)
21 (0.146)
57 (0.543)
78 (0.542)
38 (0.362)
45 (0.313)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)
Population   C-Allele T-Allele C/C
(frequency)
C/T
(frequency)
T/T
(frequency)
 Caucasian
rs2284396 Switzerland AD
CTR
0.42
0.46
0.58
0.54
20 (0.189)
28 (0.193)
50 (0.472)
77 (0.531)
36 (0.340)
40 (0.276)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)
Population   G-Allele C-Allele G/G
(frequency)
G/C
(frequency)
C/C
(frequency)
 Caucasian
rs7294695 Switzerland AD
CTR
0.48
0.40
0.52
0.60
30 (0.248)
15 (0.115)
57 (0.471)
73 (0.562)
34 (0.281)
42 (0.323)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)
Population   A-Allele G-Allele A/A
(frequency)
A/G
(frequency)
G/G
(frequency)
 Caucasian
rs2417086 Switzerland AD
CTR
0.43
0.48
0.57
0.52
22 (0.212)
32 (0.225)
46 (0.442)
73 (0.514)
36 (0.346)
37 (0.261)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)
Population   G-Allele A-Allele G/G
(frequency)
G/A
(frequency)
A/A
(frequency)
 Caucasian
rs7308022 Switzerland AD
CTR
0.08
0.07
0.92
0.93
0 (0.000)
0 (0.000)
16 (0.154)
21 (0.147)
88 (0.846)
122 (0.853)


Family-Based Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)
Population   T-Allele C-Allele T/T
(frequency)
T/C
(frequency)
C/C
(frequency)
 Other/Mixed
rs1012672 (18e) USA & UK AD
CTR
-
-
-
-
0 (-)
0 (-)
0 (-)
0 (-)
0 (-)
0 (-)
(-) :  Either no data provided, or data otherwise not eligible for inclusion (see methods for details).

Family-Based Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)
Population   C-Allele T-Allele C/C
(frequency)
C/T
(frequency)
T/T
(frequency)
 Other/Mixed
rs2302685 (14e) USA & UK AD
CTR
-
-
-
-
0 (-)
0 (-)
0 (-)
0 (-)
0 (-)
0 (-)
(-) :  Either no data provided, or data otherwise not eligible for inclusion (see methods for details).
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