AlzGene

AlzGene - Polymorphism Details

Study:

Hamilton, 2007

Gene:

ABCC8 (HI; SUR; HHF1; MRP8; PHHI; SUR1; ABC36; HRINS; TNDM2)

Protein:

ATP-binding cassette, sub-family C (CFTR/MRP), member 8 (sulfonylurea receptor (hyperinsulinemia))

Chromosome:

11 (View: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 X Y MT)

Status:

Updated 25 January 2010

Total number of polymorphisms investigated by this study: 11

Case-Control Studies (by ethnic group)
					Genotypes
Polymorphism ID# (Link to NCBI)	Population		C-Allele	G-Allele	C/C (frequency)	C/G (frequency)	G/G (frequency)
Caucasian
rs4148646	UK (I+II)	AD CTR	0.35 0.35	0.65 0.65	98 (0.109) 137 (0.133)	432 (0.480) 452 (0.439)	370 (0.411) 441 (0.428)

Case-Control Studies (by ethnic group)
					Genotypes
Polymorphism ID# (Link to NCBI)	Population		A-Allele	G-Allele	A/A (frequency)	A/G (frequency)	G/G (frequency)
Caucasian
rs4148628	UK (I+II)	AD CTR	0.15 0.16	0.85 0.84	15 (0.016) 25 (0.023)	238 (0.260) 283 (0.265)	662 (0.723) 761 (0.712)

Case-Control Studies (by ethnic group)
					Genotypes
Polymorphism ID# (Link to NCBI)	Population		T-Allele	C-Allele	T/T (frequency)	T/C (frequency)	C/C (frequency)
Caucasian
rs8192690	UK (I)	AD CTR	0.05 0.06	0.95 0.94	0 (0.000) 0 (0.000)	27 (0.108) 31 (0.118)	224 (0.892) 231 (0.882)

Case-Control Studies (by ethnic group)
					Genotypes
Polymorphism ID# (Link to NCBI)	Population		C-Allele	A-Allele	C/C (frequency)	C/A (frequency)	A/A (frequency)
Caucasian
rs757110	UK (I)	AD CTR	0.36 0.38	0.64 0.62	25 (0.102) 39 (0.147)	125 (0.512) 122 (0.459)	94 (0.385) 105 (0.395)

Case-Control Studies (by ethnic group)
					Genotypes
Polymorphism ID# (Link to NCBI)	Population		A-Allele	G-Allele	A/A (frequency)	A/G (frequency)	G/G (frequency)
Caucasian
rs1799854	UK (I)	AD CTR	0.45 0.41	0.55 0.59	53 (0.209) 53 (0.194)	120 (0.474) 120 (0.440)	80 (0.316) 100 (0.366)

Case-Control Studies (by ethnic group)
					Genotypes
Polymorphism ID# (Link to NCBI)	Population		T-Allele	C-Allele	T/T (frequency)	T/C (frequency)	C/C (frequency)
Caucasian
rs1799858	UK (I)	AD CTR	0.14 0.18	0.86 0.82	6 (0.024) 7 (0.026)	59 (0.232) 82 (0.305)	189 (0.744) 180 (0.669)

Case-Control Studies (by ethnic group)
					Genotypes
Polymorphism ID# (Link to NCBI)	Population		A-Allele	G-Allele	A/A (frequency)	A/G (frequency)	G/G (frequency)
Caucasian
rs1799857	UK (I)	AD CTR	0.43 0.46	0.57 0.54	52 (0.205) 59 (0.217)	112 (0.441) 130 (0.478)	90 (0.354) 83 (0.305)

Case-Control Studies (by ethnic group)
					Genotypes
Polymorphism ID# (Link to NCBI)	Population		T-Allele	C-Allele	T/T (frequency)	T/C (frequency)	C/C (frequency)
Caucasian
rs2074308	UK (I)	AD CTR	0.15 0.19	0.85 0.81	6 (0.024) 9 (0.035)	64 (0.257) 81 (0.312)	179 (0.719) 170 (0.654)

Case-Control Studies (by ethnic group)
					Genotypes
Polymorphism ID# (Link to NCBI)	Population		G-Allele	T-Allele	G/G (frequency)	G/T (frequency)	T/T (frequency)
Caucasian
rs8192694	UK (I)	AD CTR	0.12 0.14	0.88 0.86	3 (0.012) 6 (0.022)	54 (0.214) 66 (0.244)	195 (0.774) 198 (0.733)

Case-Control Studies (by ethnic group)
					Genotypes
Polymorphism ID# (Link to NCBI)	Population		A-Allele	G-Allele	A/A (frequency)	A/G (frequency)	G/G (frequency)
Caucasian
rs8192695	UK (I)	AD CTR	0.04 0.06	0.96 0.94	0 (0.000) 2 (0.007)	22 (0.086) 29 (0.107)	233 (0.914) 240 (0.886)

Case-Control Studies (by ethnic group)
					Genotypes
Polymorphism ID# (Link to NCBI)	Population		G-Allele	A-Allele	G/G (frequency)	G/A (frequency)	A/A (frequency)
Caucasian
rs1048099	UK (I)	AD CTR	0.49 0.50	0.51 0.50	57 (0.228) 64 (0.238)	130 (0.520) 141 (0.524)	63 (0.252) 64 (0.238)

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