AlzGene - Polymorphism Details
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 Study: Riemenschneider, 2006
 Gene: PLAU  (UPA; URK)  Entrez Gene
 Protein: plasminogen activator, urokinase   ProteinLink
 Chromosome: 10   (View: 1  2  3  4  5  6  7  8  9  10  11  12  13  14  15  16  17  18  19  20  21  22  X  Y  MT)
 Status: Updated 18 April 2011
Meta-Analysis     Gene Overview
Total number of polymorphisms investigated by this study: 23

Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)
Population   T-Allele C-Allele T/T
(frequency)
T/C
(frequency)
C/C
(frequency)
 Caucasian
rs2227564 (P141L) Italy AD
CTR
0.21
0.08
0.79
0.92
7 (0.058)
1 (0.010)
36 (0.300)
13 (0.131)
77 (0.642)
85 (0.859)
rs2227564 (P141L) Australia AD
CTR
0.28
0.20
0.72
0.80
18 (0.082)
17 (0.050)
85 (0.388)
98 (0.290)
116 (0.530)
223 (0.660)
rs2227564 (P141L) Germany (Munich) AD
CTR
0.27
0.22
0.73
0.78
25 (0.060)
8 (0.031)
177 (0.424)
98 (0.380)
215 (0.516)
152 (0.589)
rs2227564 (P141L) Germany (Bonn) AD
CTR
0.24
0.15
0.76
0.85
8 (0.073)
5 (0.029)
37 (0.339)
42 (0.243)
64 (0.587)
126 (0.728)


Case-Control Studies (by ethnic group)
  Genotypes*
Polymorphism ID#
(Link to NCBI)
Population   T-Allele C-Allele T/T
(frequency)
T/C
(frequency)
C/C
(frequency)
 Caucasian
rs2227568 Germany (Munich) AD
CTR
0.12
0.18
0.88
0.82
6 (0.014)
8 (0.031)
92 (0.218)
74 (0.288)
324 (0.768)
175 (0.681)
*Genotypes have been calculated from allele frequencies assuming Hardy-Weinberg equilibrium.

Case-Control Studies (by ethnic group)
  Genotypes*
Polymorphism ID#
(Link to NCBI)
Population   C-Allele T-Allele C/C
(frequency)
C/T
(frequency)
T/T
(frequency)
 Caucasian
rs4065 Germany (Munich) AD
CTR
0.40
0.44
0.60
0.56
68 (0.161)
49 (0.191)
203 (0.481)
127 (0.494)
151 (0.358)
81 (0.315)
*Genotypes have been calculated from allele frequencies assuming Hardy-Weinberg equilibrium.

Case-Control Studies (by ethnic group)
  Genotypes*
Polymorphism ID#
(Link to NCBI)
Population   G-Allele A-Allele G/G
(frequency)
G/A
(frequency)
A/A
(frequency)
 Caucasian
rs2675675 Germany (Munich) AD
CTR
0.23
0.25
0.77
0.75
23 (0.055)
16 (0.062)
151 (0.358)
97 (0.377)
248 (0.588)
144 (0.560)
*Genotypes have been calculated from allele frequencies assuming Hardy-Weinberg equilibrium.

Case-Control Studies (by ethnic group)
  Genotypes*
Polymorphism ID#
(Link to NCBI)
Population   A-Allele C-Allele A/A
(frequency)
A/C
(frequency)
C/C
(frequency)
 Caucasian
rs2633306 Germany (Munich) AD
CTR
0.25
0.26
0.75
0.74
27 (0.064)
17 (0.066)
159 (0.376)
98 (0.380)
237 (0.560)
143 (0.554)
*Genotypes have been calculated from allele frequencies assuming Hardy-Weinberg equilibrium.

Case-Control Studies (by ethnic group)
  Genotypes*
Polymorphism ID#
(Link to NCBI)
Population   G-Allele A-Allele G/G
(frequency)
G/A
(frequency)
A/A
(frequency)
 Caucasian
rs2688610 Germany (Munich) AD
CTR
0.41
0.48
0.59
0.52
71 (0.168)
59 (0.230)
204 (0.483)
128 (0.500)
147 (0.348)
69 (0.270)
*Genotypes have been calculated from allele frequencies assuming Hardy-Weinberg equilibrium.

Case-Control Studies (by ethnic group)
  Genotypes*
Polymorphism ID#
(Link to NCBI)
Population   A-Allele G-Allele A/A
(frequency)
A/G
(frequency)
G/G
(frequency)
 Caucasian
rs10762566 Germany (Munich) AD
CTR
0.23
0.25
0.77
0.75
23 (0.055)
16 (0.062)
152 (0.360)
96 (0.374)
247 (0.585)
145 (0.564)
*Genotypes have been calculated from allele frequencies assuming Hardy-Weinberg equilibrium.

Case-Control Studies (by ethnic group)
  Genotypes*
Polymorphism ID#
(Link to NCBI)
Population   T-Allele C-Allele T/T
(frequency)
T/C
(frequency)
C/C
(frequency)
 Caucasian
rs2675680 Germany (Munich) AD
CTR
0.41
0.47
0.59
0.53
71 (0.169)
57 (0.222)
204 (0.485)
128 (0.498)
146 (0.347)
72 (0.280)
*Genotypes have been calculated from allele frequencies assuming Hardy-Weinberg equilibrium.

Case-Control Studies (by ethnic group)
  Genotypes*
Polymorphism ID#
(Link to NCBI)
Population   T-Allele G-Allele T/T
(frequency)
T/G
(frequency)
G/G
(frequency)
 Caucasian
rs2675663 Germany (Munich) AD
CTR
0.43
0.48
0.57
0.52
77 (0.182)
59 (0.230)
206 (0.488)
128 (0.500)
139 (0.329)
69 (0.270)
*Genotypes have been calculated from allele frequencies assuming Hardy-Weinberg equilibrium.

Case-Control Studies (by ethnic group)
  Genotypes*
Polymorphism ID#
(Link to NCBI)
Population   A-Allele G-Allele A/A
(frequency)
A/G
(frequency)
G/G
(frequency)
 Caucasian
rs2688607 Germany (Munich) AD
CTR
0.24
0.25
0.76
0.75
24 (0.057)
16 (0.062)
152 (0.360)
96 (0.372)
246 (0.583)
146 (0.566)
*Genotypes have been calculated from allele frequencies assuming Hardy-Weinberg equilibrium.

Case-Control Studies (by ethnic group)
  Genotypes*
Polymorphism ID#
(Link to NCBI)
Population   C-Allele G-Allele C/C
(frequency)
C/G
(frequency)
G/G
(frequency)
 Caucasian
rs2633298 Germany (Munich) AD
CTR
0.28
0.27
0.72
0.73
32 (0.076)
19 (0.074)
169 (0.400)
102 (0.395)
221 (0.524)
137 (0.531)
*Genotypes have been calculated from allele frequencies assuming Hardy-Weinberg equilibrium.

Case-Control Studies (by ethnic group)
  Genotypes*
Polymorphism ID#
(Link to NCBI)
Population   T-Allele C-Allele T/T
(frequency)
T/C
(frequency)
C/C
(frequency)
 Caucasian
rs2459449 Germany (Munich) AD
CTR
0.26
0.28
0.74
0.72
29 (0.069)
20 (0.078)
164 (0.389)
103 (0.401)
229 (0.543)
134 (0.521)
*Genotypes have been calculated from allele frequencies assuming Hardy-Weinberg equilibrium.

Case-Control Studies (by ethnic group)
  Genotypes*
Polymorphism ID#
(Link to NCBI)
Population   G-Allele T-Allele G/G
(frequency)
G/T
(frequency)
T/T
(frequency)
 Caucasian
rs2227551 Germany (Munich) AD
CTR
0.27
0.27
0.73
0.73
30 (0.071)
18 (0.070)
164 (0.389)
101 (0.393)
228 (0.540)
138 (0.537)
*Genotypes have been calculated from allele frequencies assuming Hardy-Weinberg equilibrium.

Case-Control Studies (by ethnic group)
  Genotypes*
Polymorphism ID#
(Link to NCBI)
Population   C-Allele T-Allele C/C
(frequency)
C/T
(frequency)
T/T
(frequency)
 Caucasian
rs2227552 Germany (Munich) AD
CTR
0.27
0.29
0.73
0.71
31 (0.073)
21 (0.082)
167 (0.396)
106 (0.412)
224 (0.531)
130 (0.506)
*Genotypes have been calculated from allele frequencies assuming Hardy-Weinberg equilibrium.

Case-Control Studies (by ethnic group)
  Genotypes*
Polymorphism ID#
(Link to NCBI)
Population   A-Allele G-Allele A/A
(frequency)
A/G
(frequency)
G/G
(frequency)
 Caucasian
rs2227562 Germany (Munich) AD
CTR
0.14
0.18
0.86
0.82
8 (0.019)
9 (0.035)
99 (0.235)
77 (0.300)
315 (0.746)
171 (0.665)
*Genotypes have been calculated from allele frequencies assuming Hardy-Weinberg equilibrium.

Case-Control Studies (by ethnic group)
  Genotypes*
Polymorphism ID#
(Link to NCBI)
Population   C-Allele T-Allele C/C
(frequency)
C/T
(frequency)
T/T
(frequency)
 Caucasian
rs2227582 Germany (Munich) AD
CTR
0.01
0.01
0.99
0.99
0 (0.000)
0 (0.000)
10 (0.024)
5 (0.019)
412 (0.976)
252 (0.981)
*Genotypes have been calculated from allele frequencies assuming Hardy-Weinberg equilibrium.

Case-Control Studies (by ethnic group)
  Genotypes*
Polymorphism ID#
(Link to NCBI)
Population   C-Allele T-Allele C/C
(frequency)
C/T
(frequency)
T/T
(frequency)
 Caucasian
rs2461863 Germany (Munich) AD
CTR
0.38
0.45
0.62
0.55
61 (0.145)
51 (0.198)
199 (0.472)
127 (0.494)
162 (0.384)
79 (0.307)
*Genotypes have been calculated from allele frequencies assuming Hardy-Weinberg equilibrium.

Case-Control Studies (by ethnic group)
  Genotypes*
Polymorphism ID#
(Link to NCBI)
Population   A-Allele G-Allele A/A
(frequency)
A/G
(frequency)
G/G
(frequency)
 Caucasian
rs2688619 Germany (Munich) AD
CTR
0.41
0.47
0.59
0.53
70 (0.166)
57 (0.222)
204 (0.483)
128 (0.498)
148 (0.351)
72 (0.280)
*Genotypes have been calculated from allele frequencies assuming Hardy-Weinberg equilibrium.

Case-Control Studies (by ethnic group)
  Genotypes*
Polymorphism ID#
(Link to NCBI)
Population   C-Allele T-Allele C/C
(frequency)
C/T
(frequency)
T/T
(frequency)
 Caucasian
rs2633314 Germany (Munich) AD
CTR
0.40
0.46
0.60
0.54
69 (0.164)
53 (0.207)
203 (0.482)
127 (0.496)
149 (0.354)
76 (0.297)
*Genotypes have been calculated from allele frequencies assuming Hardy-Weinberg equilibrium.

Case-Control Studies (by ethnic group)
  Genotypes*
Polymorphism ID#
(Link to NCBI)
Population   C-Allele T-Allele C/C
(frequency)
C/T
(frequency)
T/T
(frequency)
 Caucasian
rs2633313 Germany (Munich) AD
CTR
0.40
0.45
0.60
0.55
67 (0.159)
52 (0.203)
202 (0.479)
127 (0.496)
153 (0.363)
77 (0.301)
*Genotypes have been calculated from allele frequencies assuming Hardy-Weinberg equilibrium.

Case-Control Studies (by ethnic group)
  Genotypes*
Polymorphism ID#
(Link to NCBI)
Population   A-Allele G-Allele A/A
(frequency)
A/G
(frequency)
G/G
(frequency)
 Caucasian
rs2633317 Germany (Munich) AD
CTR
0.39
0.44
0.61
0.56
63 (0.149)
50 (0.195)
200 (0.474)
127 (0.494)
159 (0.377)
80 (0.311)
*Genotypes have been calculated from allele frequencies assuming Hardy-Weinberg equilibrium.

Case-Control Studies (by ethnic group)
  Genotypes*
Polymorphism ID#
(Link to NCBI)
Population   T-Allele C-Allele T/T
(frequency)
T/C
(frequency)
C/C
(frequency)
 Caucasian
rs2633322 Germany (Munich) AD
CTR
0.24
0.26
0.76
0.74
25 (0.059)
17 (0.066)
155 (0.367)
98 (0.383)
242 (0.573)
141 (0.551)
*Genotypes have been calculated from allele frequencies assuming Hardy-Weinberg equilibrium.

Case-Control Studies (by ethnic group)
  Genotypes*
Polymorphism ID#
(Link to NCBI)
Population   T-Allele G-Allele T/T
(frequency)
T/G
(frequency)
G/G
(frequency)
 Caucasian
rs2688624 Germany (Munich) AD
CTR
0.22
0.26
0.78
0.74
20 (0.047)
18 (0.070)
143 (0.339)
99 (0.385)
259 (0.614)
140 (0.545)
*Genotypes have been calculated from allele frequencies assuming Hardy-Weinberg equilibrium.

Family-Based Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)
Population   T-Allele C-Allele T/T
(frequency)
T/C
(frequency)
C/C
(frequency)
 Caucasian
rs2227564 (P141L) Germany (Munich) AD
CTR
-
-
-
-
0 (-)
0 (-)
0 (-)
0 (-)
0 (-)
0 (-)
(-) :  Either no data provided, or data otherwise not eligible for inclusion (see methods for details).
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Polymorphisms: 2973
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