AlzGene - Polymorphism Details
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 Study: Ikram, 2008
 Gene: GAB2   Entrez Gene
 Protein: GRB2-associated binding protein 2  (Grb2-associated binder 2)  ProteinLink
 Chromosome: 11   (View: 1  2  3  4  5  6  7  8  9  10  11  12  13  14  15  16  17  18  19  20  21  22  X  Y  MT)
 Status: Updated 18 April 2011
Meta-Analysis     Gene Overview
Total number of polymorphisms investigated by this study: 22

Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   A-Allele G-Allele A/A
(frequency)		 A/G
(frequency)		 G/G
(frequency)
 Caucasian
rs4945261 Netherlands AD
CTR		 0.12
0.15		 0.88
0.85		 5 (0.011)
128 (0.025)		 96 (0.217)
1243 (0.245)		 342 (0.772)
3693 (0.729)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   T-Allele G-Allele T/T
(frequency)		 T/G
(frequency)		 G/G
(frequency)
 Caucasian
rs2373115 Netherlands AD
CTR		 -
-		 -
-		 0 (-)
0 (-)		 0 (-)
0 (-)		 0 (-)
0 (-)
(-) :  Either no data provided, or data otherwise not eligible for inclusion (see methods for details).

Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   A-Allele G-Allele A/A
(frequency)		 A/G
(frequency)		 G/G
(frequency)
 Caucasian
rs10501426 Netherlands AD
CTR		 0.12
0.15		 0.88
0.85		 7 (0.016)
139 (0.027)		 93 (0.210)
1271 (0.251)		 343 (0.774)
3654 (0.722)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   G-Allele A-Allele G/G
(frequency)		 G/A
(frequency)		 A/A
(frequency)
 Caucasian
rs10899469 Netherlands AD
CTR		 0.12
0.15		 0.88
0.85		 5 (0.011)
128 (0.025)		 95 (0.216)
1245 (0.247)		 340 (0.773)
3672 (0.728)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   G-Allele A-Allele G/G
(frequency)		 G/A
(frequency)		 A/A
(frequency)
 Caucasian
rs10899496 Netherlands AD
CTR		 0.12
0.15		 0.88
0.85		 7 (0.016)
138 (0.027)		 92 (0.208)
1286 (0.254)		 344 (0.777)
3638 (0.719)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   G-Allele A-Allele G/G
(frequency)		 G/A
(frequency)		 A/A
(frequency)
 Caucasian
rs11237451 Netherlands AD
CTR		 0.18
0.19		 0.82
0.81		 18 (0.041)
209 (0.041)		 123 (0.278)
1546 (0.305)		 302 (0.682)
3308 (0.653)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   G-Allele A-Allele G/G
(frequency)		 G/A
(frequency)		 A/A
(frequency)
 Caucasian
rs11601726 Netherlands AD
CTR		 0.12
0.12		 0.88
0.88		 7 (0.016)
90 (0.018)		 94 (0.213)
1059 (0.210)		 341 (0.771)
3893 (0.772)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   A-Allele G-Allele A/A
(frequency)		 A/G
(frequency)		 G/G
(frequency)
 Caucasian
rs11603112 Netherlands AD
CTR		 0.12
0.15		 0.88
0.85		 7 (0.016)
134 (0.027)		 90 (0.204)
1262 (0.250)		 344 (0.780)
3645 (0.723)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   A-Allele G-Allele A/A
(frequency)		 A/G
(frequency)		 G/G
(frequency)
 Caucasian
rs1318241 Netherlands AD
CTR		 0.12
0.15		 0.88
0.85		 4 (0.009)
127 (0.025)		 97 (0.219)
1236 (0.244)		 342 (0.772)
3699 (0.731)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   G-Allele A-Allele G/G
(frequency)		 G/A
(frequency)		 A/A
(frequency)
 Caucasian
rs1893447 Netherlands AD
CTR		 0.12
0.15		 0.88
0.85		 5 (0.011)
130 (0.026)		 97 (0.219)
1267 (0.250)		 341 (0.770)
3665 (0.724)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   A-Allele G-Allele A/A
(frequency)		 A/G
(frequency)		 G/G
(frequency)
 Caucasian
rs1981405 Netherlands AD
CTR		 0.09
0.11		 0.91
0.89		 2 (0.005)
76 (0.015)		 74 (0.167)
969 (0.191)		 367 (0.828)
4017 (0.794)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   A-Allele C-Allele A/A
(frequency)		 A/C
(frequency)		 C/C
(frequency)
 Caucasian
rs2292572 Netherlands AD
CTR		 0.12
0.15		 0.88
0.85		 7 (0.016)
136 (0.027)		 92 (0.208)
1272 (0.251)		 344 (0.777)
3654 (0.722)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   G-Allele A-Allele G/G
(frequency)		 G/A
(frequency)		 A/A
(frequency)
 Caucasian
rs2450129 Netherlands AD
CTR		 0.12
0.15		 0.88
0.85		 4 (0.009)
126 (0.025)		 97 (0.219)
1243 (0.246)		 342 (0.772)
3693 (0.730)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   A-Allele G-Allele A/A
(frequency)		 A/G
(frequency)		 G/G
(frequency)
 Caucasian
rs2450135 Netherlands AD
CTR		 0.05
0.03		 0.95
0.97		 2 (0.005)
8 (0.002)		 36 (0.081)
320 (0.063)		 405 (0.914)
4733 (0.935)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   G-Allele A-Allele G/G
(frequency)		 G/A
(frequency)		 A/A
(frequency)
 Caucasian
rs2511175 Netherlands AD
CTR		 0.12
0.15		 0.88
0.85		 5 (0.011)
127 (0.025)		 96 (0.217)
1244 (0.246)		 342 (0.772)
3690 (0.729)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   A-Allele G-Allele A/A
(frequency)		 A/G
(frequency)		 G/G
(frequency)
 Caucasian
rs4944196 Netherlands AD
CTR		 0.12
0.15		 0.88
0.85		 6 (0.014)
140 (0.028)		 94 (0.212)
1225 (0.242)		 343 (0.774)
3695 (0.730)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   C-Allele A-Allele C/C
(frequency)		 C/A
(frequency)		 A/A
(frequency)
 Caucasian
rs6592772 Netherlands AD
CTR		 0.12
0.15		 0.88
0.85		 5 (0.011)
127 (0.025)		 95 (0.214)
1247 (0.246)		 343 (0.774)
3689 (0.729)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   A-Allele G-Allele A/A
(frequency)		 A/G
(frequency)		 G/G
(frequency)
 Caucasian
rs7107174 Netherlands AD
CTR		 0.12
0.15		 0.88
0.85		 5 (0.011)
129 (0.026)		 95 (0.215)
1225 (0.243)		 341 (0.773)
3687 (0.731)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   A-Allele G-Allele A/A
(frequency)		 A/G
(frequency)		 G/G
(frequency)
 Caucasian
rs7112234 Netherlands AD
CTR		 0.12
0.15		 0.88
0.85		 7 (0.016)
138 (0.027)		 92 (0.208)
1274 (0.252)		 344 (0.777)
3647 (0.721)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   G-Allele A-Allele G/G
(frequency)		 G/A
(frequency)		 A/A
(frequency)
 Caucasian
rs731600 Netherlands AD
CTR		 0.12
0.15		 0.88
0.85		 5 (0.011)
129 (0.025)		 97 (0.219)
1256 (0.248)		 341 (0.770)
3678 (0.726)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   G-Allele A-Allele G/G
(frequency)		 G/A
(frequency)		 A/A
(frequency)
 Caucasian
rs7927923 Netherlands AD
CTR		 0.18
0.19		 0.82
0.81		 18 (0.041)
205 (0.041)		 124 (0.280)
1534 (0.303)		 301 (0.679)
3322 (0.656)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)		 Population   A-Allele G-Allele A/A
(frequency)		 A/G
(frequency)		 G/G
(frequency)
 Caucasian
rs7941639 Netherlands AD
CTR		 0.12
0.14		 0.88
0.86		 7 (0.016)
124 (0.026)		 85 (0.200)
1113 (0.233)		 334 (0.784)
3542 (0.741)
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AlzGene Stats
Studies: 1395
Genes: 695
Polymorphisms: 2973
Meta-analyses: 320
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