AlzGene - Polymorphism Details
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 Study: Viswanathan, 2008
 Gene: GRN  (GEP; GP88; PEPI; PGRN; PCDGF)  Entrez Gene    View on ALSGene   View on MSGene   View on PDGene
 Protein: granulin  (acrogranin; progranulin; proepithelin; granulin-epithelin; PC cell-derived growth factor)  ProteinLink
 Chromosome: 17   (View: 1  2  3  4  5  6  7  8  9  10  11  12  13  14  15  16  17  18  19  20  21  22  X  Y  MT)
 Status: Updated 18 April 2011
Meta-Analysis     Gene Overview
Total number of polymorphisms investigated by this study: 6

Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)
Population   T-Allele C-Allele T/T
(frequency)
T/C
(frequency)
C/C
(frequency)
 Caucasian
rs850713 Finland AD
CTR
0.30
0.29
0.70
0.71
47 (0.093)
55 (0.086)
214 (0.424)
267 (0.417)
244 (0.483)
318 (0.497)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)
Population   A-Allele G-Allele A/A
(frequency)
A/G
(frequency)
G/G
(frequency)
 Caucasian
rs5848 Finland AD
CTR
0.38
0.36
0.62
0.64
70 (0.138)
83 (0.128)
243 (0.480)
299 (0.461)
193 (0.381)
267 (0.411)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)
Population   C-Allele T-Allele C/C
(frequency)
C/T
(frequency)
T/T
(frequency)
 Caucasian
rs850714 Finland AD
CTR
0.32
0.31
0.68
0.69
57 (0.115)
59 (0.092)
204 (0.413)
284 (0.442)
233 (0.472)
299 (0.466)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)
Population   C-Allele T-Allele C/C
(frequency)
C/T
(frequency)
T/T
(frequency)
 Caucasian
rs3785817 Finland AD
CTR
0.35
0.35
0.65
0.65
48 (0.103)
72 (0.114)
229 (0.491)
302 (0.477)
189 (0.406)
259 (0.409)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)
Population   G-Allele A-Allele G/G
(frequency)
G/A
(frequency)
A/A
(frequency)
 Caucasian
rs4792939 Finland AD
CTR
0.16
0.19
0.84
0.81
14 (0.028)
24 (0.037)
136 (0.271)
198 (0.309)
352 (0.701)
419 (0.654)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)
Population   G-Allele A-Allele G/G
(frequency)
G/A
(frequency)
A/A
(frequency)
 Caucasian
rs850737 Finland AD
CTR
0.45
0.45
0.55
0.55
95 (0.191)
133 (0.206)
253 (0.509)
312 (0.483)
149 (0.300)
201 (0.311)
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Studies: 1395
Genes: 695
Polymorphisms: 2973
Meta-analyses: 320
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