AlzGene - Polymorphism Details
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 Study: Harold, 2009
 Gene: PVRL2  (HVEB; PRR2; CD112; PVRR2)  Entrez Gene    View on MSGene
 Protein: poliovirus receptor-related 2  (nectin 2; herpesvirus entry protein B)  ProteinLink
 Chromosome: 19   (View: 1  2  3  4  5  6  7  8  9  10  11  12  13  14  15  16  17  18  19  20  21  22  X  Y  MT)
 Status: Updated 18 April 2011
Meta-Analysis     Gene Overview
Total number of polymorphisms investigated by this study: 4

Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)
Population   G-Allele A-Allele G/G
(frequency)
G/A
(frequency)
A/A
(frequency)
 Caucasian
rs6859 Stage 1 (Germany) AD
CTR
0.52
0.45
0.48
0.55
158 (0.285)
167 (0.203)
260 (0.468)
406 (0.493)
137 (0.247)
251 (0.305)
rs6859 Stage 1 (UK, Ireland) AD
CTR
0.52
0.42
0.48
0.58
590 (0.265)
859 (0.178)
1147 (0.515)
2338 (0.484)
490 (0.220)
1630 (0.338)
rs6859 Stage 1 (USA) AD
CTR
0.51
0.43
0.49
0.57
310 (0.268)
417 (0.192)
570 (0.493)
1058 (0.486)
276 (0.239)
702 (0.322)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)
Population   G-Allele A-Allele G/G
(frequency)
G/A
(frequency)
A/A
(frequency)
 Caucasian
rs1871047 Stage 1 (Germany) AD
CTR
0.35
0.37
0.65
0.63
67 (0.121)
119 (0.144)
249 (0.449)
366 (0.444)
239 (0.431)
339 (0.411)
rs1871047 Stage 1 (UK, Ireland) AD
CTR
0.37
0.40
0.63
0.60
304 (0.137)
757 (0.157)
1029 (0.462)
2374 (0.491)
893 (0.401)
1703 (0.352)
rs1871047 Stage 1 (USA) AD
CTR
0.34
0.39
0.66
0.61
127 (0.110)
327 (0.149)
531 (0.459)
1061 (0.485)
499 (0.431)
800 (0.366)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)
Population   A-Allele G-Allele A/A
(frequency)
A/G
(frequency)
G/G
(frequency)
 Caucasian
rs377702 Stage 1 (Germany) AD
CTR
0.43
0.41
0.57
0.59
104 (0.187)
139 (0.169)
271 (0.488)
395 (0.479)
180 (0.324)
290 (0.352)
rs377702 Stage 1 (UK, Ireland) AD
CTR
0.42
0.37
0.58
0.63
391 (0.176)
671 (0.139)
1094 (0.491)
2268 (0.469)
742 (0.333)
1894 (0.392)
rs377702 Stage 1 (USA) AD
CTR
0.44
0.40
0.56
0.60
231 (0.199)
361 (0.166)
549 (0.474)
1020 (0.468)
379 (0.327)
800 (0.367)


Case-Control Studies (by ethnic group)
  Genotypes
Polymorphism ID#
(Link to NCBI)
Population   A-Allele G-Allele A/A
(frequency)
A/G
(frequency)
G/G
(frequency)
 Caucasian
rs440277 Stage 1 (Germany) AD
CTR
0.31
0.34
0.69
0.66
52 (0.094)
101 (0.123)
236 (0.425)
361 (0.438)
267 (0.481)
362 (0.439)
rs440277 Stage 1 (UK, Ireland) AD
CTR
0.28
0.31
0.72
0.69
175 (0.079)
456 (0.097)
908 (0.408)
2008 (0.427)
1144 (0.514)
2242 (0.476)
rs440277 Stage 1 (USA) AD
CTR
0.28
0.34
0.72
0.66
53 (0.096)
120 (0.129)
206 (0.374)
399 (0.429)
292 (0.530)
411 (0.442)
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Genes: 695
Polymorphisms: 2973
Meta-analyses: 320
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